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The Digestive Tract in Total Parenteral Nutrition

The Digestive Tract in Total Parenteral Nutrition Abstract The effects of four- to eight-week complete parenteral nutrition on the digestive tract were studied in puppies 8 to 10 weeks old. In these animals, the development of the gastrointestinal tract was markedly disturbed with a reduction in length, weight, and thickness of all intestinal layers. On the other hand, the microscopical structures were well preserved. There was no noticeable difference between the experimental and the control animals in the gastric pitgland ratio, the villus-crypt ratio, and the cellular component, the content of PAS-positive substance and the distribution of sudanophilic fat in the mucosal membrane, although a reduction in the mitotic index in the jejunal crypt was seen in the experimental animals. References 1. Dudrick SJ, Wilmore DW, Vars HM et al: Long-term total parenteral nutrition with growth development and positive nitrogen balance . Surgery 64:134-142, 1968. 2. Zinninger MM, Collins WT: Extension of carcinoma of the stomach into the duodenum and esophagus . Ann Surg 130:557-566, 1949.Crossref 3. Leblond CP, Stevens CE: The constant renewal of the intestinal epithelium in the albino rat . Anat Rec 100:357-377, 1948.Crossref 4. Creamer B: Dynamics of the mucosa of the small intestine in idiopathic steatorrhea . Gut 3:295-300, 1962.Crossref 5. Chang WEL, Leblond CP: Renewal of the epithelium in the descending colon of the mouse: I. Presence of three cell populations: vacuolated-columnar, mucous and argentaffin . Am J Anat 131:73-100, 1971.Crossref 6. Dowling RH: Compensatory changes in intestinal absorption . Br Med Bull 23:275-279, 1967. 7. Jervis EL, Levin RJ; Anatomic adaptation of the alimentary tract of the rat to the hyperphagia of chronic alloxan-diabetes . Nature 210:391-393, 1966.Crossref 8. Fabry P, Kujalova V: Enhanced growth of the small intestine in rats as a result of adaptation to intermittent starvation . Acta Anat 43:264-271, 1960.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1975.01360120060011
Publisher site
See Article on Publisher Site

Abstract

Abstract The effects of four- to eight-week complete parenteral nutrition on the digestive tract were studied in puppies 8 to 10 weeks old. In these animals, the development of the gastrointestinal tract was markedly disturbed with a reduction in length, weight, and thickness of all intestinal layers. On the other hand, the microscopical structures were well preserved. There was no noticeable difference between the experimental and the control animals in the gastric pitgland ratio, the villus-crypt ratio, and the cellular component, the content of PAS-positive substance and the distribution of sudanophilic fat in the mucosal membrane, although a reduction in the mitotic index in the jejunal crypt was seen in the experimental animals. References 1. Dudrick SJ, Wilmore DW, Vars HM et al: Long-term total parenteral nutrition with growth development and positive nitrogen balance . Surgery 64:134-142, 1968. 2. Zinninger MM, Collins WT: Extension of carcinoma of the stomach into the duodenum and esophagus . Ann Surg 130:557-566, 1949.Crossref 3. Leblond CP, Stevens CE: The constant renewal of the intestinal epithelium in the albino rat . Anat Rec 100:357-377, 1948.Crossref 4. Creamer B: Dynamics of the mucosa of the small intestine in idiopathic steatorrhea . Gut 3:295-300, 1962.Crossref 5. Chang WEL, Leblond CP: Renewal of the epithelium in the descending colon of the mouse: I. Presence of three cell populations: vacuolated-columnar, mucous and argentaffin . Am J Anat 131:73-100, 1971.Crossref 6. Dowling RH: Compensatory changes in intestinal absorption . Br Med Bull 23:275-279, 1967. 7. Jervis EL, Levin RJ; Anatomic adaptation of the alimentary tract of the rat to the hyperphagia of chronic alloxan-diabetes . Nature 210:391-393, 1966.Crossref 8. Fabry P, Kujalova V: Enhanced growth of the small intestine in rats as a result of adaptation to intermittent starvation . Acta Anat 43:264-271, 1960.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Jun 1, 1975

References