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THE DIAGNOSTIC SIGNIFICANCE OF BENCE-JONES ALBUMOSURIA.

THE DIAGNOSTIC SIGNIFICANCE OF BENCE-JONES ALBUMOSURIA. In the middle of the present century, Bence-Jones described a peculiar reaction of the urine, namely, the occurrence of turbidity on heating, or of a precipitate on addition of nitric acid, but clearing up on further heating and recurring on cooling. The substance on which this reaction depends was further found to be precipitable by alcohol, the precipitate being soluble in water. The body was recognized to be an albuminoid substance, but only many years later was it shown by Kühne to be an albumose, differing in its relations, however, from other albumoses. Since then not many cases have been placed on record in which the urine is reported to have this reaction present. The first two were considered to be instances of osteomalacia, and almost all of the others have been attended with disease of the bone-marrow for which the designation "multiple myelomata" has been proposed. The symptoms present http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

THE DIAGNOSTIC SIGNIFICANCE OF BENCE-JONES ALBUMOSURIA.

JAMA , Volume XXXV (20) – Nov 17, 1900

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Publisher
American Medical Association
Copyright
Copyright © 1900 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1900.02460460031003
Publisher site
See Article on Publisher Site

Abstract

In the middle of the present century, Bence-Jones described a peculiar reaction of the urine, namely, the occurrence of turbidity on heating, or of a precipitate on addition of nitric acid, but clearing up on further heating and recurring on cooling. The substance on which this reaction depends was further found to be precipitable by alcohol, the precipitate being soluble in water. The body was recognized to be an albuminoid substance, but only many years later was it shown by Kühne to be an albumose, differing in its relations, however, from other albumoses. Since then not many cases have been placed on record in which the urine is reported to have this reaction present. The first two were considered to be instances of osteomalacia, and almost all of the others have been attended with disease of the bone-marrow for which the designation "multiple myelomata" has been proposed. The symptoms present

Journal

JAMAAmerican Medical Association

Published: Nov 17, 1900

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