Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

The Diagnosis of Leydig Cell Tumors in Childhood

The Diagnosis of Leydig Cell Tumors in Childhood Abstract • We report the clinical and hormonal findings in two boys with isosexual precocity secondary to Leydig cell tumor of the testis. The hormonal profile at the initial evaluation was quite different in the two cases suggesting differences in steroid biosynthesis by the tumors. These differences indicate that a dexamethasone suppression test may be required to differentiate between Leydig cell tumors and congenital virilizing adrenal hyperplasia with adrenal rest tissue located within the testes. (Am J Dis Child 132:494-497, 1978) References 1. Giebink GS, Ruymann FB: Testicular tumors in childhood . Am J Dis Child 127:433-438, 1974. 2. Wilkins L: The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence , ed 3. Springfield, Ill, Charles C Thomas Publishers, 1965, pp 233-234. 3. Baulieu EE, Peillon F, Migeon CJ: Adrenogenital syndrome , in Eisenstein AB (ed): The Adrenal Cortex . Boston, Little, Brown & Co, 1967, pp 553-637. 4. Tanner JM: Growth at Adolescence , ed 2. Oxford, Blackwell Scientific Publications, 1962, p 32. 5. Greulich WW, Pyle SI: Radiographic Atlas of Skeletal Development of the Hand and Wrist , ed 2. Stanford, Calif, Stanford University Press, 1959. 6. de Lacerda L, Kowarski A, Johanson AJ, et al: Integrated concentration and circadian variation of plasma testosterone in normal men . J Clin Endocrinol Metab 37:366-371, 1973.Crossref 7. Gutai JP, Meyer III WJ, Kowarski AA, et al: Twenty-four hour integrated concentrations of progesterone, 17-hydroxyprogesterone and cortisol in normal male subjects . J Clin Endocrinol Metab 44:116-120, 1977.Crossref 8. Lee PA, Plotnick, LP, Steele RE, et al: Integrated concentrations of luteinizing hormone and puberty . J Clin Endocrinol Metab 43:168-172, 1976.Crossref 9. Silber RH, Porter CC: The determination of 17,21-dihydroxy-20-ketosteroids in urine and plasma . J Biol Chem 210:923-932, 1954. 10. Reinke F: Beiträge zur Histologie des Menschen: Uber Kristalloidbildungen in den interstitiellen Zellen des menschlichen Hoders . Arch Mikr Anat 47:34, 1896.Crossref 11. Mostofi FK, Price EF: Tumors of the male genital system: Atlas of tumor pathology . Fascicle 8:86-114, 1973. 12. Root A, Steinberger E, Smith K, et al: Isosexual pseudoprecocity in a 6-year-old boy with a testicular interstitial cell adenoma . J Pediatr 80:264-268, 1972.Crossref 13. Brooks RV: Androgens . Clin Endocrinol Metabol 4:503-520, 1975.Crossref 14. David M, Floret D, Touraille P, et al: Adenoma testiculaire à cellules de Leydig chez l'enfant . Pediatrie 31:457-472, 1976. 15. Wegienke LC, Kolb FO: Hormonal studies of a benign interstitial cell tumor of the testis producing androstenedione and testosterone . Acta Endocrinol 56:481-489, 1967. 16. Lipsett MB, Hertz R, Ross GT: Clinical and pathophysiologic aspects of adrenocortical carcinoma . Am J Med 35:374-383, 1963.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Loading next page...
 
/lp/american-medical-association/the-diagnosis-of-leydig-cell-tumors-in-childhood-szMNyo5FOT
Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1978.02120300054011
Publisher site
See Article on Publisher Site

Abstract

Abstract • We report the clinical and hormonal findings in two boys with isosexual precocity secondary to Leydig cell tumor of the testis. The hormonal profile at the initial evaluation was quite different in the two cases suggesting differences in steroid biosynthesis by the tumors. These differences indicate that a dexamethasone suppression test may be required to differentiate between Leydig cell tumors and congenital virilizing adrenal hyperplasia with adrenal rest tissue located within the testes. (Am J Dis Child 132:494-497, 1978) References 1. Giebink GS, Ruymann FB: Testicular tumors in childhood . Am J Dis Child 127:433-438, 1974. 2. Wilkins L: The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence , ed 3. Springfield, Ill, Charles C Thomas Publishers, 1965, pp 233-234. 3. Baulieu EE, Peillon F, Migeon CJ: Adrenogenital syndrome , in Eisenstein AB (ed): The Adrenal Cortex . Boston, Little, Brown & Co, 1967, pp 553-637. 4. Tanner JM: Growth at Adolescence , ed 2. Oxford, Blackwell Scientific Publications, 1962, p 32. 5. Greulich WW, Pyle SI: Radiographic Atlas of Skeletal Development of the Hand and Wrist , ed 2. Stanford, Calif, Stanford University Press, 1959. 6. de Lacerda L, Kowarski A, Johanson AJ, et al: Integrated concentration and circadian variation of plasma testosterone in normal men . J Clin Endocrinol Metab 37:366-371, 1973.Crossref 7. Gutai JP, Meyer III WJ, Kowarski AA, et al: Twenty-four hour integrated concentrations of progesterone, 17-hydroxyprogesterone and cortisol in normal male subjects . J Clin Endocrinol Metab 44:116-120, 1977.Crossref 8. Lee PA, Plotnick, LP, Steele RE, et al: Integrated concentrations of luteinizing hormone and puberty . J Clin Endocrinol Metab 43:168-172, 1976.Crossref 9. Silber RH, Porter CC: The determination of 17,21-dihydroxy-20-ketosteroids in urine and plasma . J Biol Chem 210:923-932, 1954. 10. Reinke F: Beiträge zur Histologie des Menschen: Uber Kristalloidbildungen in den interstitiellen Zellen des menschlichen Hoders . Arch Mikr Anat 47:34, 1896.Crossref 11. Mostofi FK, Price EF: Tumors of the male genital system: Atlas of tumor pathology . Fascicle 8:86-114, 1973. 12. Root A, Steinberger E, Smith K, et al: Isosexual pseudoprecocity in a 6-year-old boy with a testicular interstitial cell adenoma . J Pediatr 80:264-268, 1972.Crossref 13. Brooks RV: Androgens . Clin Endocrinol Metabol 4:503-520, 1975.Crossref 14. David M, Floret D, Touraille P, et al: Adenoma testiculaire à cellules de Leydig chez l'enfant . Pediatrie 31:457-472, 1976. 15. Wegienke LC, Kolb FO: Hormonal studies of a benign interstitial cell tumor of the testis producing androstenedione and testosterone . Acta Endocrinol 56:481-489, 1967. 16. Lipsett MB, Hertz R, Ross GT: Clinical and pathophysiologic aspects of adrenocortical carcinoma . Am J Med 35:374-383, 1963.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: May 1, 1978

References