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The Development of Blood-Borne Metastases: Effect of Local Trauma and Ischemia

The Development of Blood-Borne Metastases: Effect of Local Trauma and Ischemia Abstract Langenbeck is reported by Paget1 to have said, What is it that decides what organs shall suffer in a case of disseminated cancer.... When a plant goes to seed its seeds are carried in all directions but they can only live and grow if they fall on congenial soil. This concept of the relation between the circulating tumor cell and the organ in which it becomes arrested has persisted to the present day. It is of practical importance to know more about this relation and the local factors which may influence it. While Engell,2 Cole et al.,3 and others have demonstrated the presence of circulating tumor cells, and Wood4 and Zeidman5 have investigated the in vivo micropathology of the arrested tumor cell, there is little known about the local factors which determine whether a cell at one site will become a metastasis, while at another References 1. Paget, S.: The Distribution of Secondary Growths in Cancer of the Breast , Lancet 1:571-573, 1889.Crossref 2. Engell, H. C.: Cancer Cells in the Blood: 5 to 9 Year Follow-Up Study , Ann. Surg. 149: 457-461, 1959.Crossref 3. Roberts, S.; Jonasson, O.; Long, L.; McGrath, R.; McGrew, E. A., and Cole, W. H.: Clinical Significance of Cancer Cells in Circulating Blood: 2 to 5 Year Survival , Ann. Surg. 154:362-371, 1961.Crossref 4. Wood, S., Jr.: Pathogenesis of Metastasis Formation Observed in Vivo in the Rabbit Ear Chamber , A.M.A. Arch. Path. 66:550-568, 1958. 5. Zeidman, I.: The Fate of Circulating Tumor Cells: I. Passage of Cells Through Capillaries , Cancer Res. 21:38-39, 1961. 6. deLong, R. P., and Coman, D. R.: Relative Susceptibility of Various Organs to Tumor Transplantation , Cancer Res. 10:513-515, 1950. 7. Romsdahl, M. D.; Chu, E. W.; Hume, R., and Smith, R. R.: Method for Cytological Detection of Tumor Cells in Mouse Blood in Vitro , J. Nat. Cancer Inst. 26:19-23, 1961. 8. Cliffton, E E., and Agostino, D.: Factors Affecting the Development of Metastatic Cancer: Effect of Alterations in Clotting Mechanism , Cancer 15:276-283, 1962.Crossref 9. Baserga, R., and Shubik, P.: Action of Cortisone on Disseminated Tumor Cells After Removal of Primary Growth , Science 121:100, 1955.Crossref 10. Selecki, E. E.: Study of Metastasis Distribution of Erlich Ascites Tumour Cells in Mice , Aust. J. Exp. Biol. Med. Sci. 37:489-498, 1959.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

The Development of Blood-Borne Metastases: Effect of Local Trauma and Ischemia

Archives of Surgery , Volume 85 (5) – Nov 1, 1962

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Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1962.01310050022005
Publisher site
See Article on Publisher Site

Abstract

Abstract Langenbeck is reported by Paget1 to have said, What is it that decides what organs shall suffer in a case of disseminated cancer.... When a plant goes to seed its seeds are carried in all directions but they can only live and grow if they fall on congenial soil. This concept of the relation between the circulating tumor cell and the organ in which it becomes arrested has persisted to the present day. It is of practical importance to know more about this relation and the local factors which may influence it. While Engell,2 Cole et al.,3 and others have demonstrated the presence of circulating tumor cells, and Wood4 and Zeidman5 have investigated the in vivo micropathology of the arrested tumor cell, there is little known about the local factors which determine whether a cell at one site will become a metastasis, while at another References 1. Paget, S.: The Distribution of Secondary Growths in Cancer of the Breast , Lancet 1:571-573, 1889.Crossref 2. Engell, H. C.: Cancer Cells in the Blood: 5 to 9 Year Follow-Up Study , Ann. Surg. 149: 457-461, 1959.Crossref 3. Roberts, S.; Jonasson, O.; Long, L.; McGrath, R.; McGrew, E. A., and Cole, W. H.: Clinical Significance of Cancer Cells in Circulating Blood: 2 to 5 Year Survival , Ann. Surg. 154:362-371, 1961.Crossref 4. Wood, S., Jr.: Pathogenesis of Metastasis Formation Observed in Vivo in the Rabbit Ear Chamber , A.M.A. Arch. Path. 66:550-568, 1958. 5. Zeidman, I.: The Fate of Circulating Tumor Cells: I. Passage of Cells Through Capillaries , Cancer Res. 21:38-39, 1961. 6. deLong, R. P., and Coman, D. R.: Relative Susceptibility of Various Organs to Tumor Transplantation , Cancer Res. 10:513-515, 1950. 7. Romsdahl, M. D.; Chu, E. W.; Hume, R., and Smith, R. R.: Method for Cytological Detection of Tumor Cells in Mouse Blood in Vitro , J. Nat. Cancer Inst. 26:19-23, 1961. 8. Cliffton, E E., and Agostino, D.: Factors Affecting the Development of Metastatic Cancer: Effect of Alterations in Clotting Mechanism , Cancer 15:276-283, 1962.Crossref 9. Baserga, R., and Shubik, P.: Action of Cortisone on Disseminated Tumor Cells After Removal of Primary Growth , Science 121:100, 1955.Crossref 10. Selecki, E. E.: Study of Metastasis Distribution of Erlich Ascites Tumour Cells in Mice , Aust. J. Exp. Biol. Med. Sci. 37:489-498, 1959.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Nov 1, 1962

References