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/lp/american-medical-association/the-deadly-quartet-upper-body-obesity-glucose-intolerance-38oZdeBxM9
- Publisher
- American Medical Association
- Copyright
- Copyright © 1989 American Medical Association. All Rights Reserved.
- ISSN
- 0003-9926
- eISSN
- 1538-3679
- DOI
- 10.1001/archinte.1989.00390070054005
- Publisher site
- See Article on Publisher Site
Abstract
Abstract • The contribution of obesity to cardiovascular risk has not been adequately appreciated because of a failure to recognize the involvement of upper-body predominance of body weight with hypertension, diabetes, and hypertriglyceridemia even in the absence of significant overall obesity. This article examines the evidence that upper-body obesity, as usually induced by caloric excess in the presence of androgens, mediates these problems by way of hyperinsulinemia. Because of these interrelationships, there is a need to identify and prevent upper-body obesity or, failing that, to provide therapies that will control the associated problems without aggravating hyperinsulinemia. (Arch Intern Med. 1989;149:1514-1520) References 1. Taylor WC, Pass TM, Shepard DS, Komaroff AL. Cholesterol reduction and life expectancy: a model incorporating multiple risk factors . Ann Intern Med . 1987;106:605-614.Crossref 2. Garraway WM, Whisnant JP. 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Journal
Archives of Internal Medicine – American Medical Association
Published: Jul 1, 1989