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THE CORRELATION OF WIDAL'S POSTDIGESTIVE LEUKOPENIA AS A TEST FOR LIVER FUNCTION WITH THE NORMAL RHYTHM OF THE LEUKOCYTES

THE CORRELATION OF WIDAL'S POSTDIGESTIVE LEUKOPENIA AS A TEST FOR LIVER FUNCTION WITH THE NORMAL... Abstract Widal, Abrami and Iancovesco1 described a test for liver dysfunction which they believe is based on an anaphylactic blood reaction. This reaction, to which they gave the name of hemoclastic crisis, manifests itself as (a) leukopenia with a relative lymphocytosis, (b) fall of blood pressure, (c) decrease in the refractometric index of the serum and (d) an increase in the coagulation time of the blood. The authors stated that these phenomena are a response of the presence of low proteins (peptones) in the general circulation. Their theory for the appearance of these products in the general circulation is that during digestion of protein the partially digested proteins which reach the liver via the portal circulation pass through and enter the general circulation when the liver is diseased. The normal liver prevents this transmission, because it has the property of arresting the low proteins (proteopexic function). These authors offered the following References 1. Widal, F.; Abrami, P., and Iancovesco, N.: L'épreuve de l'hémoclasie digestive dans l'étude de l'insuffisance hépatique , Presse méd. 28:893 ( (Dec. 11) ) 1920. 2. Shaw, A. F. Bernard: A Study of the Haemoclastic Crisis Test for Liver Function, With Special Reference to the Leucocytic Changes , Brit. M. J. 1:914 ( (May 16) ) 1925.Crossref 3. Mauriac, P., and Cabouat, P.: Paris méd. 11:407, 1921. 4. Servantie; Panzat and Monod: J. de méd. de Bordeaux 12:360, 1921. 5. Kobryner, A.: Compt. rend. Soc. de biol. 90:1475, 1924. 6. Storm van Leeuwen, W.; Bien, Z., and Varekamp, H.: On Alimentary Leucocytosis in Its Relation to the Crise Hémoclasique of Widal , J. Exper. Med. 36:414, 1922.Crossref 7. Middleton, W. S., and Thewlis, Ethel: The Leukocytic Phase of Haemoclastic Shock , J. Lab. & Clin. Med. 10:462, 1924 and 1925. 8. Feinblatt, Henry M.: Alimentary Leukocytosis in Eighty Normal Men: A Study in Reference to the Crise Hémoclasique of Widal , J. A. M. A. 80:613 ( (March 3) ) 1923. 9. Feinblatt, Henry M.: Alimentary Leukocytosis in Various Pathologic Conditions: A Further Study in Reference to the Crise Hémoclasique of Widal , Arch. Int. Med. 33:210 ( (Feb.) ) 1924. 10. Feinblatt (footnotes 8 and 9). 11. Brown, Thomas: Notes on Hemoclastic Shock as a Test of Liver Function , Ann. Clin. Med. 1:89 ( (Sept.) ) 1922. 12. Sabin, F. R.; Cunningham, R. S.; Doan, C. A., and Kindwall, J. A.: The Normal Rhythm of the White Blood Cells , Bull. Johns Hopkins Hosp. 37:14, 1925. 13. Shaw (footnote 2). 14. Mauriac and Cabouat (footnote 3). 15. Servantie, Panzat and Monod (footnote 4). 16. Shaw, A. F. B.: The Diurnal Tides of the Leucocytes of Man , J. Path. & Bact. 33:1, 1927. 17. Doan, C. A., and Zerfas, Leon G.: The Rhythmic Range of the White Blood Cells in Human Pathological Leucopenic and Leucocytic States with a Study of Thirty-Two Human Bone Marrows , J. Exper. Med. 46:511, 1927. 18. Smith, Christiana: and McDowell, Anna Mary: Normal Rhythm of White Blood Cells in Women , Arch. Int. Med. 43:68 ( (Jan.) ) 1929. 19. Wallace, George B., and Diamond, Joseph S.: The Significance of Urobilinogen in the Urine as a Test for Liver Function , Arch. Int. Med. 35:698 ( (June) ) 1925. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

THE CORRELATION OF WIDAL'S POSTDIGESTIVE LEUKOPENIA AS A TEST FOR LIVER FUNCTION WITH THE NORMAL RHYTHM OF THE LEUKOCYTES

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Publisher
American Medical Association
Copyright
Copyright © 1930 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1930.00140180119012
Publisher site
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Abstract

Abstract Widal, Abrami and Iancovesco1 described a test for liver dysfunction which they believe is based on an anaphylactic blood reaction. This reaction, to which they gave the name of hemoclastic crisis, manifests itself as (a) leukopenia with a relative lymphocytosis, (b) fall of blood pressure, (c) decrease in the refractometric index of the serum and (d) an increase in the coagulation time of the blood. The authors stated that these phenomena are a response of the presence of low proteins (peptones) in the general circulation. Their theory for the appearance of these products in the general circulation is that during digestion of protein the partially digested proteins which reach the liver via the portal circulation pass through and enter the general circulation when the liver is diseased. The normal liver prevents this transmission, because it has the property of arresting the low proteins (proteopexic function). These authors offered the following References 1. Widal, F.; Abrami, P., and Iancovesco, N.: L'épreuve de l'hémoclasie digestive dans l'étude de l'insuffisance hépatique , Presse méd. 28:893 ( (Dec. 11) ) 1920. 2. Shaw, A. F. Bernard: A Study of the Haemoclastic Crisis Test for Liver Function, With Special Reference to the Leucocytic Changes , Brit. M. J. 1:914 ( (May 16) ) 1925.Crossref 3. Mauriac, P., and Cabouat, P.: Paris méd. 11:407, 1921. 4. Servantie; Panzat and Monod: J. de méd. de Bordeaux 12:360, 1921. 5. Kobryner, A.: Compt. rend. Soc. de biol. 90:1475, 1924. 6. Storm van Leeuwen, W.; Bien, Z., and Varekamp, H.: On Alimentary Leucocytosis in Its Relation to the Crise Hémoclasique of Widal , J. Exper. Med. 36:414, 1922.Crossref 7. Middleton, W. S., and Thewlis, Ethel: The Leukocytic Phase of Haemoclastic Shock , J. Lab. & Clin. Med. 10:462, 1924 and 1925. 8. Feinblatt, Henry M.: Alimentary Leukocytosis in Eighty Normal Men: A Study in Reference to the Crise Hémoclasique of Widal , J. A. M. A. 80:613 ( (March 3) ) 1923. 9. Feinblatt, Henry M.: Alimentary Leukocytosis in Various Pathologic Conditions: A Further Study in Reference to the Crise Hémoclasique of Widal , Arch. Int. Med. 33:210 ( (Feb.) ) 1924. 10. Feinblatt (footnotes 8 and 9). 11. Brown, Thomas: Notes on Hemoclastic Shock as a Test of Liver Function , Ann. Clin. Med. 1:89 ( (Sept.) ) 1922. 12. Sabin, F. R.; Cunningham, R. S.; Doan, C. A., and Kindwall, J. A.: The Normal Rhythm of the White Blood Cells , Bull. Johns Hopkins Hosp. 37:14, 1925. 13. Shaw (footnote 2). 14. Mauriac and Cabouat (footnote 3). 15. Servantie, Panzat and Monod (footnote 4). 16. Shaw, A. F. B.: The Diurnal Tides of the Leucocytes of Man , J. Path. & Bact. 33:1, 1927. 17. Doan, C. A., and Zerfas, Leon G.: The Rhythmic Range of the White Blood Cells in Human Pathological Leucopenic and Leucocytic States with a Study of Thirty-Two Human Bone Marrows , J. Exper. Med. 46:511, 1927. 18. Smith, Christiana: and McDowell, Anna Mary: Normal Rhythm of White Blood Cells in Women , Arch. Int. Med. 43:68 ( (Jan.) ) 1929. 19. Wallace, George B., and Diamond, Joseph S.: The Significance of Urobilinogen in the Urine as a Test for Liver Function , Arch. Int. Med. 35:698 ( (June) ) 1925.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Dec 1, 1930

References