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THE CONVULSION THRESHOLD OF VARIOUS PARTS OF THE CAT'S BRAIN

THE CONVULSION THRESHOLD OF VARIOUS PARTS OF THE CAT'S BRAIN Abstract In this investigation we have attempted to determine the relative ease or difficulty with which convulsions can be produced by electrical stimulation of various parts of the cat's brain. The problem has significance because it bears directly on the question of whether or not a special part of the brain is concerned with the production of convulsions, a question of major importance to those interested in the etiology of epileptic seizures. METHOD With a cat under ether anesthesia a 24 gage needle electrode of the type used by Adrian and Bronk1 was inserted into the brain through a perforated metal plug screwed into a small bur hole in the skull. This type of electrode is made by running an insulated wire through a hollow needle, such as is used for venipuncture or subcutaneous injection, and by sealing the wire in place. In our experiments the wire in the needle References 1. Adrian, E. D., and Bronk, D. W.: The Discharge of Impulses in Motor Nerve Fibers , J. Physiol. 67:119, 1929. 2. Gibbs, E. I., and Gibbs, F. A.: A Purring Center in the Cat's Brain , Science , to be published. 3. Kappers, C. U. A.: Die vergleichende Anatomie des Nervensystems der Wirbeltiere und des Menschen , Haarlem, Netherlands, de Erven F. Bohn, 1921, vol. 2. 4. Ingram, W. R.; Ranson, S. W., and Hannett, F. I.: Pupillary Dilatation Produced by Direct Stimulation of the Tegmentum of the Brain Stem , Am. J. Physiol. 98:687, 1931. 5. Ranson, S. W., and Magoun, H. W.: Respiratory and Pupillary Reactions Induced by Electrical Stimulation of the Hypothalamus , Arch. Neurol. & Psychiat. 29:1179 ( (June) ) 1933. 6. Gibbs, F. A.: Frequency with Which Tumors in Various Parts of the Brain Produce Certain Symptoms , Arch. Neurol. & Psychiat. 28:969 ( (Nov.) ) 1932. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

THE CONVULSION THRESHOLD OF VARIOUS PARTS OF THE CAT'S BRAIN

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Publisher
American Medical Association
Copyright
Copyright © 1936 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1936.02260010119009
Publisher site
See Article on Publisher Site

Abstract

Abstract In this investigation we have attempted to determine the relative ease or difficulty with which convulsions can be produced by electrical stimulation of various parts of the cat's brain. The problem has significance because it bears directly on the question of whether or not a special part of the brain is concerned with the production of convulsions, a question of major importance to those interested in the etiology of epileptic seizures. METHOD With a cat under ether anesthesia a 24 gage needle electrode of the type used by Adrian and Bronk1 was inserted into the brain through a perforated metal plug screwed into a small bur hole in the skull. This type of electrode is made by running an insulated wire through a hollow needle, such as is used for venipuncture or subcutaneous injection, and by sealing the wire in place. In our experiments the wire in the needle References 1. Adrian, E. D., and Bronk, D. W.: The Discharge of Impulses in Motor Nerve Fibers , J. Physiol. 67:119, 1929. 2. Gibbs, E. I., and Gibbs, F. A.: A Purring Center in the Cat's Brain , Science , to be published. 3. Kappers, C. U. A.: Die vergleichende Anatomie des Nervensystems der Wirbeltiere und des Menschen , Haarlem, Netherlands, de Erven F. Bohn, 1921, vol. 2. 4. Ingram, W. R.; Ranson, S. W., and Hannett, F. I.: Pupillary Dilatation Produced by Direct Stimulation of the Tegmentum of the Brain Stem , Am. J. Physiol. 98:687, 1931. 5. Ranson, S. W., and Magoun, H. W.: Respiratory and Pupillary Reactions Induced by Electrical Stimulation of the Hypothalamus , Arch. Neurol. & Psychiat. 29:1179 ( (June) ) 1933. 6. Gibbs, F. A.: Frequency with Which Tumors in Various Parts of the Brain Produce Certain Symptoms , Arch. Neurol. & Psychiat. 28:969 ( (Nov.) ) 1932.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Jan 1, 1936

References