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The Central Influence upon the Electroretinogram Evoked by Double Flashes

The Central Influence upon the Electroretinogram Evoked by Double Flashes Abstract The electrical activity of the retina is influenced by a previous illumination with a flash of light. Dodt1 (1952) found that the amplitude of the b-wave of the human electroretinogram (ERG) is increased from bare perceptibility to the normal value when the dark interval between the previous and test flashes is changed from 0.1 to 1.5 seconds. A similar depression of the b-wave following a previous illumination was confirmed by many investigators.2-5 Mahneke3 (1957) has also noted that this depression phase is followed by a supernormal phase which is evidenced by increased amplitude of the b-wave Thus, the recovery cycle of the human ERG after a previous conditioning flash is characterized by an initial depression and a late facilitation of the b-wave. However, little attention has so far been paid to this late facilitation of the b-wave in the recovery cycle. The References 1. Dodt, E.: Beiträge zur Elektrophysiologie des Auges: II. Über Hemmungsvorgänge in der menschlichen Retina , Graefe. Arch. Ophthal. 153:152, 1952.Crossref 2. Wagman, I.; Waldman, J.; Naidoff, D.; Feinschil, L., and Cahan, R.: The Recording of the Electroretinogram in Humans and in Animals , Amer. J. Ophthal. 38:60 (July, (Pt. 2) ) 1954. 3. Mahneke, A.: Electroretinography with Double Flashes , Acta Ophthal (Kbh.) 35:131, 1957. 4. Burian, H. M., and Spivey, B. E.: The Effect of Twin Flashes and of Repetitive Light Stimuli on the Human Electroretinogram , Amer. J. Ophthal. 48:274 (Sept., (Pt. 2) ) 1959. 5. Sverak, J., and Peregrin, J.: A Contribution to the Physiology of the Electroretinographic Double-Flash Test , Ophthalmologica 140:267, 1960.Crossref 6. Jacobson, J. H., and Suzuki, T.: Studies of Centrifugal Effects on the ERG, 1st International Society for Clinical Electroretinography , Stockholm, 1961. 7. Karpe, G.: Basis of Clinical Electroretinography , Acta Ophthal. (Kbh.) Suppl. 24:1, 1945. 8. Jacobson, J. H., and Gestring, G. F.: Centrifugal Influence upon the Electroretinogram , A.M.A. Arch. Ophthal. 60:295, 1958.Crossref 9. Motokawa, K., and Ebe, M.: Antidromic Stimulation of Optic Nerve and Photosensitivity of Cat Retina , J. Neurophysiol. 17:364, 1954. 10. Granit, R.: Centrifugal and Antidromic Effects on Ganglion Cells of Retina , J. Neurophysiol. 18:388, 1955. 11. Dodt, E.: Centrifugal Impulses in Rabbit's Retina , J. Neurophysiol. 19:301, 1956. 12. Suzuki, T.: ERG of Congenital Totally Color-Weak Eye Accompanied by Lesion of Optic Nerve , A.M.A. Arch. Ophthal. `62:386, 1959.Crossref 13. Mita, T.; Suzuki, T.; Nikara, T., and Ogawa, T.: The Effects of Some Anesthetics and of the Optic Nerve Section on ERG , Iwate Med. J. 13: 1321, 1962. 14. Arden, G.; Granit, R., and Ponte, F.: Phase of Suppression Following Each Retinal B-Wave in Flicker , J. Neurophysiol. 23:305, 1960. 15. Wohlzogen, F. X.: Beeinflussung des Säuger-ERG durch zentral-nervös wirksame Substanzen , Z. Biol. 108:217, 1955. 16. Eccles, R. M., and Lundberg, A.: Supraspinal Control of Interneurones Mediating Spinal Reflexes , J. Physiol. (Lond.) 147:565, 1959. 17. Kuno, M., and Perl, E. R.: Alteration of Spinal Reflexes by Interaction with Suprasegmental and Dorsal Root Activity , J. Physiol. (Lond.) 151: 103, 1960. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

The Central Influence upon the Electroretinogram Evoked by Double Flashes

Archives of Ophthalmology , Volume 68 (4) – Oct 1, 1962

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Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1962.00960030536020
Publisher site
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Abstract

Abstract The electrical activity of the retina is influenced by a previous illumination with a flash of light. Dodt1 (1952) found that the amplitude of the b-wave of the human electroretinogram (ERG) is increased from bare perceptibility to the normal value when the dark interval between the previous and test flashes is changed from 0.1 to 1.5 seconds. A similar depression of the b-wave following a previous illumination was confirmed by many investigators.2-5 Mahneke3 (1957) has also noted that this depression phase is followed by a supernormal phase which is evidenced by increased amplitude of the b-wave Thus, the recovery cycle of the human ERG after a previous conditioning flash is characterized by an initial depression and a late facilitation of the b-wave. However, little attention has so far been paid to this late facilitation of the b-wave in the recovery cycle. The References 1. Dodt, E.: Beiträge zur Elektrophysiologie des Auges: II. Über Hemmungsvorgänge in der menschlichen Retina , Graefe. Arch. Ophthal. 153:152, 1952.Crossref 2. Wagman, I.; Waldman, J.; Naidoff, D.; Feinschil, L., and Cahan, R.: The Recording of the Electroretinogram in Humans and in Animals , Amer. J. Ophthal. 38:60 (July, (Pt. 2) ) 1954. 3. Mahneke, A.: Electroretinography with Double Flashes , Acta Ophthal (Kbh.) 35:131, 1957. 4. Burian, H. M., and Spivey, B. E.: The Effect of Twin Flashes and of Repetitive Light Stimuli on the Human Electroretinogram , Amer. J. Ophthal. 48:274 (Sept., (Pt. 2) ) 1959. 5. Sverak, J., and Peregrin, J.: A Contribution to the Physiology of the Electroretinographic Double-Flash Test , Ophthalmologica 140:267, 1960.Crossref 6. Jacobson, J. H., and Suzuki, T.: Studies of Centrifugal Effects on the ERG, 1st International Society for Clinical Electroretinography , Stockholm, 1961. 7. Karpe, G.: Basis of Clinical Electroretinography , Acta Ophthal. (Kbh.) Suppl. 24:1, 1945. 8. Jacobson, J. H., and Gestring, G. F.: Centrifugal Influence upon the Electroretinogram , A.M.A. Arch. Ophthal. 60:295, 1958.Crossref 9. Motokawa, K., and Ebe, M.: Antidromic Stimulation of Optic Nerve and Photosensitivity of Cat Retina , J. Neurophysiol. 17:364, 1954. 10. Granit, R.: Centrifugal and Antidromic Effects on Ganglion Cells of Retina , J. Neurophysiol. 18:388, 1955. 11. Dodt, E.: Centrifugal Impulses in Rabbit's Retina , J. Neurophysiol. 19:301, 1956. 12. Suzuki, T.: ERG of Congenital Totally Color-Weak Eye Accompanied by Lesion of Optic Nerve , A.M.A. Arch. Ophthal. `62:386, 1959.Crossref 13. Mita, T.; Suzuki, T.; Nikara, T., and Ogawa, T.: The Effects of Some Anesthetics and of the Optic Nerve Section on ERG , Iwate Med. J. 13: 1321, 1962. 14. Arden, G.; Granit, R., and Ponte, F.: Phase of Suppression Following Each Retinal B-Wave in Flicker , J. Neurophysiol. 23:305, 1960. 15. Wohlzogen, F. X.: Beeinflussung des Säuger-ERG durch zentral-nervös wirksame Substanzen , Z. Biol. 108:217, 1955. 16. Eccles, R. M., and Lundberg, A.: Supraspinal Control of Interneurones Mediating Spinal Reflexes , J. Physiol. (Lond.) 147:565, 1959. 17. Kuno, M., and Perl, E. R.: Alteration of Spinal Reflexes by Interaction with Suprasegmental and Dorsal Root Activity , J. Physiol. (Lond.) 151: 103, 1960.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Oct 1, 1962

References