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The Case of the Frozen Addicts

The Case of the Frozen Addicts The Case of the Frozen Addicts is the account of an enthusiastic young doctor who parlays the wanton, antisocial, and criminal behavior of his patients into worldwide recognition as a neuroscientist. As the narrative unfolds, Dr J. William Langston encounters several substance abusers who have been rendered immobile and speechless following use of designer drugs. His clinical observations persuade him that they are suffering from a pernicious form of Parkinson's disease. Confirmation comes when they respond to treatment with levodopa, but only with the heavy burden of side effects that limit therapy, returning them to their devastated frozen states. Through ingenious sleuthing, Langston identifies the culpable compound as MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). He hypothesizes that MPTP may destroy cells in the substantia nigra, impairing the production of dopamine. His theory is proven when he replicates MPTP-induced parkinsonism in monkeys and reverses it with levodopa. Since his patients cannot use levodopa because of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

The Case of the Frozen Addicts

JAMA , Volume 275 (5) – Feb 7, 1996

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Publisher
American Medical Association
Copyright
Copyright © 1996 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1996.03530290079047
Publisher site
See Article on Publisher Site

Abstract

The Case of the Frozen Addicts is the account of an enthusiastic young doctor who parlays the wanton, antisocial, and criminal behavior of his patients into worldwide recognition as a neuroscientist. As the narrative unfolds, Dr J. William Langston encounters several substance abusers who have been rendered immobile and speechless following use of designer drugs. His clinical observations persuade him that they are suffering from a pernicious form of Parkinson's disease. Confirmation comes when they respond to treatment with levodopa, but only with the heavy burden of side effects that limit therapy, returning them to their devastated frozen states. Through ingenious sleuthing, Langston identifies the culpable compound as MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). He hypothesizes that MPTP may destroy cells in the substantia nigra, impairing the production of dopamine. His theory is proven when he replicates MPTP-induced parkinsonism in monkeys and reverses it with levodopa. Since his patients cannot use levodopa because of

Journal

JAMAAmerican Medical Association

Published: Feb 7, 1996

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