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The Cardiomyopathy of Hypothyroidism Revisited: Are Children Different Than Adults?

The Cardiomyopathy of Hypothyroidism Revisited: Are Children Different Than Adults? Abstract Amidst the wide range of social, political, and scientific developments that are presently capturing our attention, the year 1980 will quietly mark the centennial anniversary of the first report of gross anatomical findings in the heart of patients with myxedema by Sir William Ord.1 The celebration of this event would hardly receive notice in a modern medical journal were it not for a remarkable resurgence of interest in the study of the heart as a target organ for thyroid hormone action. This welcomed new trend results from the creative application of seemingly unrelated advances in the disciplines of endocrinology and cardiology. By combining radioimmunoassay techniques for measurement of thyroid function with the versatility of echocardiography and systolic time intervals as noninvasive tools for the assessment of functional and structural cardiac alterations, investigators are rapidly adding to our understanding of hypothyroid heart disease. The study by Hayford et al in References 1. Ord WM: Cases of Myxedema . Trans Clin Soc London 13:15-22, 1880. 2. Report of a Committee of the Clinical Society of London nominated Dec 14, 1883 to Investigate the Subject of Myxedema . Trans Clin Soc London 21:( (suppl) ), 35-46, 1888. 3. Zondek H: Das Myxodemherz . MMW 65:1180-1186, 1918. 4. Fahr G: Myxedema heart . JAMA 84:345-349, 1925.Crossref 5. Kern RA, Soloff LA, Snape WJ, et al: Pericardial effusion: A constant, early and major factor in the cardiac syndrome of hypothyroidism . Am J Med Sci 217:609-618, 1949.Crossref 6. Graettinger JS, Muenster JJ, Chechie CS, et al: A correlation of clinical and hemodynamic studies in patients with hypothyroidism . J Clin Invest 37:502-510, 1958.Crossref 7. Amidi M, Leon DF, deGroot WJ, et al: Effect of the thyroid state on myocardial contractility and ventricular ejection in man . Circulation 38:229-239, 1968.Crossref 8. Hillis WS, Bremmer WF, Lawrie TD, et al: Systolic timer intervals in thyroid disease . Clin Endocrinol 4:617-624, 1975.Crossref 9. Crowley WF, Ridgway EC, Bough EW, et al: Noninvasive evaluation of cardiac function in hypothyroidism . N Engl J Med 296:1-6, 1977.Crossref 10. Santos AD, Miller RP, Mathew PK, et al: Echocardiographic characterization of the reversible cardiomyopathy of hypothyroidism . Am J Med 68:675-682, 1980.Crossref 11. Miller RP, Santos AD, Roth-Moyo L, et al: Hypothyroid heart disease: A reversible obstructive cardiomyopathy. Presented at the 61st annual meeting of the Endocrine Society, June 15, 1979. 12. Fahr G: Myxedema heart: A report based upon a study of 17 cases of myxedema . Am Heart J 8:91-101, 1932.Crossref 13. Oppenheimer JH: Initiation of thyroid hormone action . N Engl J Med 292:1063-1068, 1975.Crossref 14. Ciraldi T, Marinetti GV: Thyroxin and Propylthiouracil effects in vivo on alpha and beta adrenergic receptors in rat heart . Biochem Biophys Comm 74:984-991, 1977.Crossref 15. Brewer DB: Myxedema; autopsy report with histochemical observations on the nature of the mucoid infiltrations . J Pathol Bacteriol 63:503-512, 1951.Crossref 16. Von Knorring J: Analysis of myocardial mucopolysaccharides in hyper and hypothyroid rats and guinea-pigs . Ann Med Exp Fenn 48:8-15, 1970. 17. Smallridge RC, Rajfer S, David J, et al: Acromegaly and the heart . Am J Med 66:22-27, 1979.Crossref 18. Gutgesell HP, Speer ME, Rosenberg HS: Characterization of the cardiomyopathy of infants of diabetic mothers . Circulation 61:441-450, 1980.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

The Cardiomyopathy of Hypothyroidism Revisited: Are Children Different Than Adults?

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Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1980.02130180005002
Publisher site
See Article on Publisher Site

Abstract

Abstract Amidst the wide range of social, political, and scientific developments that are presently capturing our attention, the year 1980 will quietly mark the centennial anniversary of the first report of gross anatomical findings in the heart of patients with myxedema by Sir William Ord.1 The celebration of this event would hardly receive notice in a modern medical journal were it not for a remarkable resurgence of interest in the study of the heart as a target organ for thyroid hormone action. This welcomed new trend results from the creative application of seemingly unrelated advances in the disciplines of endocrinology and cardiology. By combining radioimmunoassay techniques for measurement of thyroid function with the versatility of echocardiography and systolic time intervals as noninvasive tools for the assessment of functional and structural cardiac alterations, investigators are rapidly adding to our understanding of hypothyroid heart disease. The study by Hayford et al in References 1. Ord WM: Cases of Myxedema . Trans Clin Soc London 13:15-22, 1880. 2. Report of a Committee of the Clinical Society of London nominated Dec 14, 1883 to Investigate the Subject of Myxedema . Trans Clin Soc London 21:( (suppl) ), 35-46, 1888. 3. Zondek H: Das Myxodemherz . MMW 65:1180-1186, 1918. 4. Fahr G: Myxedema heart . JAMA 84:345-349, 1925.Crossref 5. Kern RA, Soloff LA, Snape WJ, et al: Pericardial effusion: A constant, early and major factor in the cardiac syndrome of hypothyroidism . Am J Med Sci 217:609-618, 1949.Crossref 6. Graettinger JS, Muenster JJ, Chechie CS, et al: A correlation of clinical and hemodynamic studies in patients with hypothyroidism . J Clin Invest 37:502-510, 1958.Crossref 7. Amidi M, Leon DF, deGroot WJ, et al: Effect of the thyroid state on myocardial contractility and ventricular ejection in man . Circulation 38:229-239, 1968.Crossref 8. Hillis WS, Bremmer WF, Lawrie TD, et al: Systolic timer intervals in thyroid disease . Clin Endocrinol 4:617-624, 1975.Crossref 9. Crowley WF, Ridgway EC, Bough EW, et al: Noninvasive evaluation of cardiac function in hypothyroidism . N Engl J Med 296:1-6, 1977.Crossref 10. Santos AD, Miller RP, Mathew PK, et al: Echocardiographic characterization of the reversible cardiomyopathy of hypothyroidism . Am J Med 68:675-682, 1980.Crossref 11. Miller RP, Santos AD, Roth-Moyo L, et al: Hypothyroid heart disease: A reversible obstructive cardiomyopathy. Presented at the 61st annual meeting of the Endocrine Society, June 15, 1979. 12. Fahr G: Myxedema heart: A report based upon a study of 17 cases of myxedema . Am Heart J 8:91-101, 1932.Crossref 13. Oppenheimer JH: Initiation of thyroid hormone action . N Engl J Med 292:1063-1068, 1975.Crossref 14. Ciraldi T, Marinetti GV: Thyroxin and Propylthiouracil effects in vivo on alpha and beta adrenergic receptors in rat heart . Biochem Biophys Comm 74:984-991, 1977.Crossref 15. Brewer DB: Myxedema; autopsy report with histochemical observations on the nature of the mucoid infiltrations . J Pathol Bacteriol 63:503-512, 1951.Crossref 16. Von Knorring J: Analysis of myocardial mucopolysaccharides in hyper and hypothyroid rats and guinea-pigs . Ann Med Exp Fenn 48:8-15, 1970. 17. Smallridge RC, Rajfer S, David J, et al: Acromegaly and the heart . Am J Med 66:22-27, 1979.Crossref 18. Gutgesell HP, Speer ME, Rosenberg HS: Characterization of the cardiomyopathy of infants of diabetic mothers . Circulation 61:441-450, 1980.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jun 1, 1980

References