Abstract It is our purpose in this paper to consider the healing strength of the fractured fibulae of rats on a standard diet. In a preliminary report on this subject, two of us (Dr. Lindsay and Dr. Howes)1 presented an original method for the determination of the healing strength of fibular calluses in rats from the inception of the fracture to the restitution of normal strength in the healing bone. The findings obtained at that time were in several instances later found to be either inadequate or inconclusive. However, on the basis afforded by this first contribution, the work has been carefully repeated with the result that a much better comprehension of the problem has been made possible. In some instances, important changes were made in technic, while in all cases the factors concerned have been clarified to a greater extent than existed before. PROCEDURE We found early that the References 1. Howes, Edward L., and Lindsay, Merrill K.: The Breaking Strength of Healing Fractures , J. Bone & Joint Surg. 13:491 ( (July) ) 1931. 2. Moise, T. S., and Smith, A. H.: Diet and Tissue Growth: I. The Regeneration of Liver Tissue on Various Adequate Diets , J. Exper. Med. 40:13, 1924. 3. William R. Thompson of the department of pathology aided in developing this formula. 4. The choice of the value J = (10.W)2/3 may seem strange, but it was employed to coincide with results of preliminary calculations where J = W2/3 was taken with W in decigrams. 5. Kay, H. D.: Plasma Phosphatase: II. The Enzyme in Disease Particularly in Bone Disease , J. Biol. Chem. 89:249, 1930. 6. Harris, H. A.: Cod Liver Oil and the Vitamins in Relation to Bone Growth and Rickets , Am. J. M. Sc. 181:453 ( (April) ) 1931. 7. Fell, H. B. and Robison, Robert: The Growth, Development and Phosphatase Activity of Embryonic Avian Femora and Limb Buds Cultivated in Vitro , Biochem. J. 23:767, 1929. 8. Eliason, L. E.: Nelson's Loose Leaf Surgery , New York, T. Nelson & Son, 1927, vol. 3, p. 249.
Archives of Surgery – American Medical Association
Published: Mar 1, 1932