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The Autonomous Functioning Thyroid Nodule: Therapeutic Considerations

The Autonomous Functioning Thyroid Nodule: Therapeutic Considerations Abstract THE radioactive iodine scintigram will identify a minority of clinically evident thyroid nodules as functional to a greater degree than the surrounding follicular tissue. The management of such lesions requires that special consideration be given to two observations. First, the functioning nodule itself, as defined below, has correlated to date with a benign histological pattern,1 and second, its secretory activity may or may not produce a hyperthyroid state.2 In our experience, acknowledgement of the foregoing has raised the question not only of whether surgical removal is still the treatment of choice, but also if at any given time any treatment is necessary. The purpose of this report is to attempt to answer both questions insofar as our current knowledge enables us to do so. Characteristics of the Functioning Autonomous Nodule Relating an in vivo nodule to specific benign histologic characteristics requires precise evaluation. The nodule must be shown References 1. Miller, J.M., and Hamburger, J.I.: The Thyroid Scintigram , Radiology , 84:66 ( (Jan) ) 1965.Crossref 2. Miller, J.M.; Horn, R.C.; and Block, M.A.: The Evolution of Toxic Nodular Goiter , Arch Intern Med 113:72, 1964.Crossref 3. Miller, J.M.; Horn, R.A.; and Block, M.A.: J Clin Endocr, Oct, to be published. 4. Skillern, P.G.; McCullagh, E.P.; and Clamen, M.: Radioiodine in Diagnosis and Therapy of Hyperthyroidism: Hyperthyroidism Caused by a Hyperfunctioning Thyroid Adenoma , Arch Intern Med 110:888 ( (Dec) ) 1962.Crossref 5. Molnar, G.D., et al: On the Hyperfunctioning Solitary Thyroid Nodule , Mayo Clin Proc 40:665 ( (Sept) ) 1965. 6. McCullagh, E.P.: Current Methods of Diagnosis and Management of Goiter , Cleveland Clin Quart 31:85 ( (April) ) 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

The Autonomous Functioning Thyroid Nodule: Therapeutic Considerations

Archives of Surgery , Volume 96 (3) – Mar 1, 1968

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Publisher
American Medical Association
Copyright
Copyright © 1968 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1968.01330210064011
Publisher site
See Article on Publisher Site

Abstract

Abstract THE radioactive iodine scintigram will identify a minority of clinically evident thyroid nodules as functional to a greater degree than the surrounding follicular tissue. The management of such lesions requires that special consideration be given to two observations. First, the functioning nodule itself, as defined below, has correlated to date with a benign histological pattern,1 and second, its secretory activity may or may not produce a hyperthyroid state.2 In our experience, acknowledgement of the foregoing has raised the question not only of whether surgical removal is still the treatment of choice, but also if at any given time any treatment is necessary. The purpose of this report is to attempt to answer both questions insofar as our current knowledge enables us to do so. Characteristics of the Functioning Autonomous Nodule Relating an in vivo nodule to specific benign histologic characteristics requires precise evaluation. The nodule must be shown References 1. Miller, J.M., and Hamburger, J.I.: The Thyroid Scintigram , Radiology , 84:66 ( (Jan) ) 1965.Crossref 2. Miller, J.M.; Horn, R.C.; and Block, M.A.: The Evolution of Toxic Nodular Goiter , Arch Intern Med 113:72, 1964.Crossref 3. Miller, J.M.; Horn, R.A.; and Block, M.A.: J Clin Endocr, Oct, to be published. 4. Skillern, P.G.; McCullagh, E.P.; and Clamen, M.: Radioiodine in Diagnosis and Therapy of Hyperthyroidism: Hyperthyroidism Caused by a Hyperfunctioning Thyroid Adenoma , Arch Intern Med 110:888 ( (Dec) ) 1962.Crossref 5. Molnar, G.D., et al: On the Hyperfunctioning Solitary Thyroid Nodule , Mayo Clin Proc 40:665 ( (Sept) ) 1965. 6. McCullagh, E.P.: Current Methods of Diagnosis and Management of Goiter , Cleveland Clin Quart 31:85 ( (April) ) 1964.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Mar 1, 1968

References