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The Association of Lichen Sclerosus and Erosive Lichen Planus of the Vulva With Autoimmune Disease

The Association of Lichen Sclerosus and Erosive Lichen Planus of the Vulva With Autoimmune Disease STUDY The Association of Lichen Sclerosus and Erosive Lichen Planus of the Vulva With Autoimmune Disease A Case-Control Study Susan M. Cooper, MD, MRCP; Iaisha Ali, MRCP; Maha Baldo, MSc; Fenella Wojnarowska, MD Objective: To investigate the prevalence of autoim- Main Outcome Measures: The presence or absence mune disease and circulating autoantibodies in of a personal or family history of autoimmune disorder, women with lichen sclerosus (LS) and erosive lichen and the presence or absence of 1 or more circulating au- planus (LP) of the vulva and to compare these with a toantibodies. control population. Results: The mean ages of patients with LS, patients with erosive LP, and control patients were 63, 61, and 61 years, Design: Age- and sex-matched controlled study. respectively. The mean age of the 230 controls exam- ined (including those who had serum autoantibodies as- Setting: The vulval clinics in Oxfordshire, England, for sayed) was 62 years. Autoimmune disorders were more patients with LS and LP. Healthy controls were re- frequent in patients with erosive LP compared with con- cruited from the hospital and community. trols (29% vs 9%; P.001) and in those with LS com- pared with controls (28% vs 9%; P.001). Circulating Patients: http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

The Association of Lichen Sclerosus and Erosive Lichen Planus of the Vulva With Autoimmune Disease

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Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/archderm.144.11.1432
pmid
19015417
Publisher site
See Article on Publisher Site

Abstract

STUDY The Association of Lichen Sclerosus and Erosive Lichen Planus of the Vulva With Autoimmune Disease A Case-Control Study Susan M. Cooper, MD, MRCP; Iaisha Ali, MRCP; Maha Baldo, MSc; Fenella Wojnarowska, MD Objective: To investigate the prevalence of autoim- Main Outcome Measures: The presence or absence mune disease and circulating autoantibodies in of a personal or family history of autoimmune disorder, women with lichen sclerosus (LS) and erosive lichen and the presence or absence of 1 or more circulating au- planus (LP) of the vulva and to compare these with a toantibodies. control population. Results: The mean ages of patients with LS, patients with erosive LP, and control patients were 63, 61, and 61 years, Design: Age- and sex-matched controlled study. respectively. The mean age of the 230 controls exam- ined (including those who had serum autoantibodies as- Setting: The vulval clinics in Oxfordshire, England, for sayed) was 62 years. Autoimmune disorders were more patients with LS and LP. Healthy controls were re- frequent in patients with erosive LP compared with con- cruited from the hospital and community. trols (29% vs 9%; P.001) and in those with LS com- pared with controls (28% vs 9%; P.001). Circulating Patients:

Journal

JAMA DermatologyAmerican Medical Association

Published: Nov 1, 2008

References