Abstract To the Editor.— McGuffin et al1 used what they purported to be our criteria for schizophrenia and found them to be unreliable and "unsatisfactory for detecting the familiality of schizophrenia." Our response is as follows.1. We substantially revised our criteria in 19782 by adding the requirements of first-rank symptoms and a clear consciousness to the inclusion criteria, and the presence of diagnosable affective disorder to the exclusion criteria, and by requiring the presence of only one (rather than all three) inclusion criterion for a diagnosis of schizophrenia. Nonetheless, McGuffin et al chose to use our 1975 criteria3; what was their rationale for doing so?2. Our 1975 criteria were not accurately portrayed by McGuffin et al. We nowhere referred to "incoherent speech," but specified "blocking, nonsequiturs, neologisms, word approximations, and verbigeration" as the types of formal thought disorder required. A "restricted affect" alone could not satisfy our References 1. McGuffin P, Farmer AE, Gottesman II, Murray RM, Reveley AM: Twin concordance for operationally defined schizophrenia: Confirmation of familiality and heritability . Arch Gen Psychiatry 1984;41:541-545.Crossref 2. Taylor MA, Abrams R: The prevalence of schizophrenia: A reassessment using modern diagnostic criteria . Am J Psychiatry 1978;135:945-948. 3. Taylor MA, Abrams R, Gaztanaga P: Manicdepressive illness and schizophrenia: A partial validation of research diagnostic criteria utilizing neuropsychological testing . Compr Psychiatry 1975;16:91-96.Crossref 4. Abrams R, Taylor MA: The genetics of schizophrenia: A reassessment using modern criteria . Am J Psychiatry 1983;140:171-175. 5. Young MA, Tanner MA, Meltzer HY: Operational definitions of schizophrenia: What do they identify? J Nerv Ment Dis 1982;170:443-447.Crossref 6. Pope HG Jr, Jonas JM, Cohen BM, Lipinsky JF: Failure to find evidence of schizophrenia in first-degree relatives of schizophrenic probands . Am J Psychiatry 1982;139:826-828. 7. Lidz T, Blatt S: Critique of the Danish American studies of the biological and adoptive relatives of adoptees who became schizophrenic . Am J Psychiatry 1983;140:426-435.
Archives of General Psychiatry – American Medical Association
Published: Apr 1, 1985
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