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The Antisocial Brain: Psychopathy Matters

The Antisocial Brain: Psychopathy Matters ORIGINAL ARTICLE ONLINE FIRST A Structural MRI Investigation of Antisocial Male Violent Offenders Sarah Gregory, PhD; Dominic ffytche, MD, MRCPsych; Andrew Simmons, PhD; Veena Kumari, PhD; Matthew Howard, PhD; Sheilagh Hodgins, PhD; Nigel Blackwood, MA, MD, MRCPsych Context: The population of men who display persis- Main Outcome Measures: Gray matter volumes as assessed by structural magnetic resonance imaging and tent antisocial and violent behavior is heterogeneous. Callous-unemotional traits in childhood and psycho- volumetric voxel-based morphometry analyses. pathic traits in adulthood characterize a distinct sub- Results: Offenders with ASPDP displayed significantly group. reduced GM volumes bilaterally in the anterior rostral pre- frontal cortex (Brodmann area 10) and temporal poles Objective: To identify structural gray matter (GM) dif- (Brodmann area 20/38) relative to offenders with ASPD−P ferences between persistent violent offenders who meet and nonoffenders. These reductions were not attributable criteria for antisocial personality disorder and the syn- to substance use disorders. Offenders with ASPD−P exhib- drome of psychopathy (ASPDP) and those meeting cri- ited GM volumes similar to the nonoffenders. teria only for ASPD (ASPD−P). Conclusions: Reduced GM volume within areas impli- Design: Cross-sectional case-control structural mag- cated in empathic processing, moral reasoning, and pro- netic resonance imaging study. cessing http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2012 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/archgenpsychiatry.2012.222
pmid
22566562
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE ONLINE FIRST A Structural MRI Investigation of Antisocial Male Violent Offenders Sarah Gregory, PhD; Dominic ffytche, MD, MRCPsych; Andrew Simmons, PhD; Veena Kumari, PhD; Matthew Howard, PhD; Sheilagh Hodgins, PhD; Nigel Blackwood, MA, MD, MRCPsych Context: The population of men who display persis- Main Outcome Measures: Gray matter volumes as assessed by structural magnetic resonance imaging and tent antisocial and violent behavior is heterogeneous. Callous-unemotional traits in childhood and psycho- volumetric voxel-based morphometry analyses. pathic traits in adulthood characterize a distinct sub- Results: Offenders with ASPDP displayed significantly group. reduced GM volumes bilaterally in the anterior rostral pre- frontal cortex (Brodmann area 10) and temporal poles Objective: To identify structural gray matter (GM) dif- (Brodmann area 20/38) relative to offenders with ASPD−P ferences between persistent violent offenders who meet and nonoffenders. These reductions were not attributable criteria for antisocial personality disorder and the syn- to substance use disorders. Offenders with ASPD−P exhib- drome of psychopathy (ASPDP) and those meeting cri- ited GM volumes similar to the nonoffenders. teria only for ASPD (ASPD−P). Conclusions: Reduced GM volume within areas impli- Design: Cross-sectional case-control structural mag- cated in empathic processing, moral reasoning, and pro- netic resonance imaging study. cessing

Journal

JAMA PsychiatryAmerican Medical Association

Published: Sep 1, 2012

References