Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

The Aged Human Sebaceous Gland: The Effects of Hormone Administration and a Comparison with Adolescent Gland Function

The Aged Human Sebaceous Gland: The Effects of Hormone Administration and a Comparison with... Abstract Introduction A new technique for measuring the sebum excretion rate has been developed. It eliminates some of the errors inherent in other methods. The amount of sebum excreted by the sebaceous gland has been shown to be influenced by several major factors. Miescher and Schönberg20 have demonstrated that the amount of sebum excreted is dependent upon the size of the sebaceous gland. The larger the gland, the more sebum excreted, and vice versa. The size of the gland changes with age. Prior to puberty, in the human the sebaceous gland is small, and little sebum is excreted.7,23 At puberty there is a great increase in sebum excretion which continues through adolescence.14,16 There are conflicting reports as to whether adolescent males7,16,28 or females5 have a higher level of sebum excretion, but aged women have a much lower level of sebum excretion than aged References 1. Supplied as Delatestryl by E. R. Squibb & Sons (each ml. contains 200 mgm. testosterone enanthate) 2. Supplied as Delalutin by E. R. Squibb & Sons (each ml. contains 125 mg. hydroxyprogesterone caproate). 3. Aron-Brunetière, R.: An Attempt at a Physiological Explanation of Seborrhea and Acne Vulgaris: Therapeutic Results , Brit. J. Dermat. 65:157-164 ( (May) ) 1953.Crossref 4. Brun, R.: Recherches sur la sécrétion sudorale et la secretion sébacée , Archives des Sciences 7:243-304, 1954. 5. Brun, R.; Enderlin, K., and deWeck, A.: Variations de la couche sébacée de l'avant suivant l'age et le sexe , Acta dermat.-venereol. 35:311-317, 1955. 6. Brun, R.; Enderlin, K., and Kull, E.: A propos de Sebum-tests , Dermatologica 106:165-170, 1953.Crossref 7. Brun, R., and Grasset, N.: Contribution à l'étude de la pathogénie de l'acné vulgaire , Dermatologica 116:416-419, 1958.Crossref 8. Butcher, E. O., and Parnell, J. P.: The Distribution and Factors Influencing the Amount of Sebum on the Skin of the Forehead , J. Invest. Dermat. 10:31-38 ( (Jan.) ) 1948. 9. Emanuel, S.: Quantitative Determinations of Sebaceous Glands' Functions, with Particular Mention of the Method Employed , Acta dermat.-venereol. 17:444-456 ( (Sept.) ) 1936. 10. Enderlin, K., and Brun, R.: Nouvelles Experiences sur la sécretion sébacée , Dermatologica 108:235-256, 1954.Crossref 11. Hamilton, J. B.: Male Hormone Substance: a Prime Factor in Acne , J. Clin. Endocrinol. 1:570-592 ( (July) ) 1941.Crossref 12. Haskin, D.; Lasher, N., and Rothman, S.: Some Effects of ACTH, Cortisone, Progesterone, and Testosterone on Sebaceous Glands in the White Rat , J. Invest. Dermat. 20:207-212 ( (March) ) 1953. 13. Herrmann, F., and Prose, P. H.: Studies on the Ether-Soluble Substances on the Human Skin: I: Quantity and "Replacement Sum," J. Invest. Dermat 16:217-230 ( (April) ) 1951. 14. Kirk, E.: Quantitative Determinations of the Skin Lipid Secretion in Middle-Aged and Old Individuals , J. Gerontol. 3:251-266 ( (Oct.) ) 1948.Crossref 15. Kirk, J. E., and Chieffi, M.: The 20-Minute Rate of Sebaceous Secretion in the Forehead , J. Invest. Dermat. 27:15-17 ( (July) ) 1956.Crossref 16. Kligman, A. M., and Ginsberg, D.: Immunity of the Adult Scalp to Infection with Microsporum audouini , J. Invest. Dermat. 14:345-358 ( (May) ) 1950. 17. Kligman, A. M., and Shelley, W. B.: An Investigation of the Biology of the Sebaceous Gland . J. Invest. Dermat. 30:99-125 ( (March) ) 1958. 18. Kvorning, S. A.: Investigations into the Pharmocology of Skin Fats and of Ointments: II. On the Occurrence and Replenishment of Fat on Skin in Normal Individuals , Acta pharmacol. et toxicol. 5:262-269, 1949.Crossref 19. Lasher, N.; Lorincz, A. L., and Rothman, S.: Hormonal Effects on Sebaceous Glands in the White Rat: II. The Effects of the Pituitary-Adrenal Axis , J. Invest. Dermat. 22:25-31 ( (Jan.) ) 1954.Crossref 20. Lasher, N.; Lorincz, A. L., and Rothman, S.: Hormonal Effects on Sebaceous Glands in the White Rat: III. Evidence for the Presence of a Pituitary Sebaceous Gland Tropic Factor , J. Invest. Dermat. 24:499-505 ( (May) ) 1955.Crossref 21. Lorincz, A. L., and Lancaster, G.: Anterior Pituitary Preparation with Tropic Activity for Sebaceous Preputial and Harderian Glands , Science 126:124-125 ( (July 19) ) 1957.Crossref 22. Miescher, G., and Schönberg, A.: Untersuchungen über die Funktion der Talgdrüsen , Bull. schweiz, Akad. med. Wissensch. 1:101-114, 1944. 23. Rony, H. R., and Zakon, S. J.: Effect of Androgens on the Sebaceous Glands of Human Skin , Arch. Dermat. & Syph. 48:601-604 ( (Dec.) ) 1943. 24. Rothman, S. et al.: Physiology and Biochemistry of the Skin , Chicago, The Univ. Chicago Press, 1954, Chap. 12 , Sebaceous Gland Excretion, pp. 284-308. 25. Rothman, S., and Schaaf, F.: Chemie der Haut , in J. Jadassohn, Handb. der. Haut.-u. Geschlechtskrankheiten , 1/2:161-377, Berlin, Springer-Verlag, 1929. 26. Savard, K.: Personal communication to author. 27. Savard, K.; Dorfman, R. I.; Baggett, B., and Engel, L. L.: Biosynthesis of Androgens from Progesterone by Human Testicular Tissue in Vitro , J. Clin. Endocrinol. 16:1629-1630 ( (Dec.) ) 1956. 28. Slaunwhite, W. R., Jr., and Samuels, L. T.: Progesterone as a Precursor of Testicular Androgens , J. Biol. Chem. 220:341-352 ( (May) ) 1956. 29. Spoor, H. J.: Measurements of Emolliency and Emollient Penetration , Drug and Cosmetic Industry 81:42 ( (July) ) 1957. 30. Suzuki, S.: Zur Physiologie und Pathologie der Talgsekretion, besonders bei Lues , Jap. J. Dermat. & Urol. 40:203-212 ( (Dec. 20) ) 1936. 31. Zeligman, I., and Hubener, L. F.: Experimental Production of Acne by Progesterone , A.M.A. Arch. Dermat. 76:652-658 ( (Nov.) ) 1957. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

The Aged Human Sebaceous Gland: The Effects of Hormone Administration and a Comparison with Adolescent Gland Function

A.M.A. Archives of Dermatology , Volume 80 (6) – Dec 1, 1959

Loading next page...
 
/lp/american-medical-association/the-aged-human-sebaceous-gland-the-effects-of-hormone-administration-MNv3Ln070x
Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1959.01560240015002
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction A new technique for measuring the sebum excretion rate has been developed. It eliminates some of the errors inherent in other methods. The amount of sebum excreted by the sebaceous gland has been shown to be influenced by several major factors. Miescher and Schönberg20 have demonstrated that the amount of sebum excreted is dependent upon the size of the sebaceous gland. The larger the gland, the more sebum excreted, and vice versa. The size of the gland changes with age. Prior to puberty, in the human the sebaceous gland is small, and little sebum is excreted.7,23 At puberty there is a great increase in sebum excretion which continues through adolescence.14,16 There are conflicting reports as to whether adolescent males7,16,28 or females5 have a higher level of sebum excretion, but aged women have a much lower level of sebum excretion than aged References 1. Supplied as Delatestryl by E. R. Squibb & Sons (each ml. contains 200 mgm. testosterone enanthate) 2. Supplied as Delalutin by E. R. Squibb & Sons (each ml. contains 125 mg. hydroxyprogesterone caproate). 3. Aron-Brunetière, R.: An Attempt at a Physiological Explanation of Seborrhea and Acne Vulgaris: Therapeutic Results , Brit. J. Dermat. 65:157-164 ( (May) ) 1953.Crossref 4. Brun, R.: Recherches sur la sécrétion sudorale et la secretion sébacée , Archives des Sciences 7:243-304, 1954. 5. Brun, R.; Enderlin, K., and deWeck, A.: Variations de la couche sébacée de l'avant suivant l'age et le sexe , Acta dermat.-venereol. 35:311-317, 1955. 6. Brun, R.; Enderlin, K., and Kull, E.: A propos de Sebum-tests , Dermatologica 106:165-170, 1953.Crossref 7. Brun, R., and Grasset, N.: Contribution à l'étude de la pathogénie de l'acné vulgaire , Dermatologica 116:416-419, 1958.Crossref 8. Butcher, E. O., and Parnell, J. P.: The Distribution and Factors Influencing the Amount of Sebum on the Skin of the Forehead , J. Invest. Dermat. 10:31-38 ( (Jan.) ) 1948. 9. Emanuel, S.: Quantitative Determinations of Sebaceous Glands' Functions, with Particular Mention of the Method Employed , Acta dermat.-venereol. 17:444-456 ( (Sept.) ) 1936. 10. Enderlin, K., and Brun, R.: Nouvelles Experiences sur la sécretion sébacée , Dermatologica 108:235-256, 1954.Crossref 11. Hamilton, J. B.: Male Hormone Substance: a Prime Factor in Acne , J. Clin. Endocrinol. 1:570-592 ( (July) ) 1941.Crossref 12. Haskin, D.; Lasher, N., and Rothman, S.: Some Effects of ACTH, Cortisone, Progesterone, and Testosterone on Sebaceous Glands in the White Rat , J. Invest. Dermat. 20:207-212 ( (March) ) 1953. 13. Herrmann, F., and Prose, P. H.: Studies on the Ether-Soluble Substances on the Human Skin: I: Quantity and "Replacement Sum," J. Invest. Dermat 16:217-230 ( (April) ) 1951. 14. Kirk, E.: Quantitative Determinations of the Skin Lipid Secretion in Middle-Aged and Old Individuals , J. Gerontol. 3:251-266 ( (Oct.) ) 1948.Crossref 15. Kirk, J. E., and Chieffi, M.: The 20-Minute Rate of Sebaceous Secretion in the Forehead , J. Invest. Dermat. 27:15-17 ( (July) ) 1956.Crossref 16. Kligman, A. M., and Ginsberg, D.: Immunity of the Adult Scalp to Infection with Microsporum audouini , J. Invest. Dermat. 14:345-358 ( (May) ) 1950. 17. Kligman, A. M., and Shelley, W. B.: An Investigation of the Biology of the Sebaceous Gland . J. Invest. Dermat. 30:99-125 ( (March) ) 1958. 18. Kvorning, S. A.: Investigations into the Pharmocology of Skin Fats and of Ointments: II. On the Occurrence and Replenishment of Fat on Skin in Normal Individuals , Acta pharmacol. et toxicol. 5:262-269, 1949.Crossref 19. Lasher, N.; Lorincz, A. L., and Rothman, S.: Hormonal Effects on Sebaceous Glands in the White Rat: II. The Effects of the Pituitary-Adrenal Axis , J. Invest. Dermat. 22:25-31 ( (Jan.) ) 1954.Crossref 20. Lasher, N.; Lorincz, A. L., and Rothman, S.: Hormonal Effects on Sebaceous Glands in the White Rat: III. Evidence for the Presence of a Pituitary Sebaceous Gland Tropic Factor , J. Invest. Dermat. 24:499-505 ( (May) ) 1955.Crossref 21. Lorincz, A. L., and Lancaster, G.: Anterior Pituitary Preparation with Tropic Activity for Sebaceous Preputial and Harderian Glands , Science 126:124-125 ( (July 19) ) 1957.Crossref 22. Miescher, G., and Schönberg, A.: Untersuchungen über die Funktion der Talgdrüsen , Bull. schweiz, Akad. med. Wissensch. 1:101-114, 1944. 23. Rony, H. R., and Zakon, S. J.: Effect of Androgens on the Sebaceous Glands of Human Skin , Arch. Dermat. & Syph. 48:601-604 ( (Dec.) ) 1943. 24. Rothman, S. et al.: Physiology and Biochemistry of the Skin , Chicago, The Univ. Chicago Press, 1954, Chap. 12 , Sebaceous Gland Excretion, pp. 284-308. 25. Rothman, S., and Schaaf, F.: Chemie der Haut , in J. Jadassohn, Handb. der. Haut.-u. Geschlechtskrankheiten , 1/2:161-377, Berlin, Springer-Verlag, 1929. 26. Savard, K.: Personal communication to author. 27. Savard, K.; Dorfman, R. I.; Baggett, B., and Engel, L. L.: Biosynthesis of Androgens from Progesterone by Human Testicular Tissue in Vitro , J. Clin. Endocrinol. 16:1629-1630 ( (Dec.) ) 1956. 28. Slaunwhite, W. R., Jr., and Samuels, L. T.: Progesterone as a Precursor of Testicular Androgens , J. Biol. Chem. 220:341-352 ( (May) ) 1956. 29. Spoor, H. J.: Measurements of Emolliency and Emollient Penetration , Drug and Cosmetic Industry 81:42 ( (July) ) 1957. 30. Suzuki, S.: Zur Physiologie und Pathologie der Talgsekretion, besonders bei Lues , Jap. J. Dermat. & Urol. 40:203-212 ( (Dec. 20) ) 1936. 31. Zeligman, I., and Hubener, L. F.: Experimental Production of Acne by Progesterone , A.M.A. Arch. Dermat. 76:652-658 ( (Nov.) ) 1957.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Dec 1, 1959

References