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V. Sydenstricker, S. Singal, A. Briggs, N. Devaughn, H. Isbell (1942)
PRELIMINARY OBSERVATIONS ON "EGG WHITE INJURY" IN MAN AND ITS CURE WITH A BIOTIN CONCENTRATE.Science, 95 2459
P. West, W. Woglom (1942)
Abnormalities in the Distribution of Biotin in Certain Tumors and Embryo TissuesCancer Research, 2
E. Snell, R. Eakin, R. Williams (1940)
A Quantitative Test for Biotin and Observations Regarding its Occurrence and PropertiesJournal of the American Chemical Society, 62
V. Vigneaud, J. Spangler, D. Burk, C. Kensler, K. Sugiura, C. Rhoads (1942)
THE PROCARCINOGENIC EFFECT OF BIOTIN IN BUTTER YELLOW TUMOR FORMATION.Science, 95 2459
Philip West, W. Woglom (1941)
THE BIOTIN CONTENT OF TUMORS AND OTHER TISSUES.Science, 93 2422
A rational basis for the treatment of cancer is to deprive the neoplastic tissue of the components required for its growth. This basis presumes that neoplastic cells either contain certain constituents lacked by their normal analogues or that the requirement for those constituents by the cancer tissue is greater than that of normal tissue. Recently, several types of carcinoma were reported to contain abnormally high concentrations of biotin.1 About the same time it was noted that the addition of biotin to diets which prevented in rats the development of hepatomas induced by the feeding of butter yellow broke down the protection those diets otherwise afforded.2 These observations do not necessarily imply that biotin is required for the induction or growth of neoplastic tissue. They do suggest the possibility however that, if biotin should be withheld from patients bearing cancer, the growth of the neoplasm might be decreased to
JAMA – American Medical Association
Published: Apr 17, 1943
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