Abstract Introduction Current findings strongly suggest that intraocular pressure (IOP) of the cat eye is dependent upon venous pressure2-5,7-10 which in turn can be regulated by changes in resistance of the iris artery and its radial branches.6Acetazolamide has been demonstrated to lower intraocular pressure, at least in part, by its ability to produce a fall in venous pressure2,3 through its constrictive effect of the iris blood vessels.6 Many other agents, even though of diverse origin and activity, which have been shown capable of producing a lowering of IOP in patients with glaucoma, have all been found to have the common effect of producing an increase in resistance in the iris artery.9Recently dilutions of serum were also shown capable of producing increases in resistance of the iris artery. Almost all of this serum vasoconstrictor activity could be ascribed to a substance which had many of References 1. Marci, F. J.; Wanko, T.; and Grimes, P. A.: Elasticity of Eye , Arch 58:513-519, 1959. 2. Macri, F. J.: Acetazolamide and Venous Pressure of Eye , Arch Ophthal 63:953-965, 1960.Crossref 3. Macri, F. J.: Further Studies on Action of Acetazolamide and Venous Pressure of Eye , Arch Ophthal 64:550-552, 1960.Crossref 4. Macri, F. J.: Interdependence of Venous and Eye Pressure , Arch Ophthal 65:442-449, 1961.Crossref 5. Macri, F. J.: Vascular Pressure Relationships and Intraocular Pressure , Arch Ophthal 65:571-574, 1961.Crossref 6. Macri, F. J., and Brown, J. G.: Constrictive Action of Acetazolamide on Iris Arteries of Cat , Arch Ophthal 66:570-577, 1961.Crossref 7. Macri, F. J.: Further Studies on Relationship of Intrascleral Venous Pressure and Eye Pressure , Arch Ophthal 69:622-625, 1963.Crossref 8. Macri, F. J.: Constrictive Action of Serum and Serum Proteins on Iris Artery , Arch Ophthal 70:546-553, 1963.Crossref 9. Macri, F. J.: Constrictor Action of Various Anti-glaucoma Drugs on Iris Artery of Cat , Int J Neuropharmacol 3:205-212, 1964.Crossref 10. Macri, F. J.: Intraocular and Vascular Pressures of Cat Eye, Exp Eye Res, to be published. 11. Paladini, A. C., et al: Estimation of Angiotensin in Blood , J Lab Clin Med 53:264-271, 1959. 12. von Sallmann, L., and Lowenstein, O.: Responses of Intraocular Pressure and Cutaneous Vessels to Electric Stimulation in Diencephalon, (Ninth Francis I. Proctor Lecture) , Amer J Ophthal 39: 11-29, 1955. 13. Wong, V. G., and Macri, F. J.: Vasculature of Cat Eye , Arch Ophthal 72:351-358, 1964.Crossref
Archives of Ophthalmology – American Medical Association
Published: Apr 1, 1965
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