Abstract Sixty-four North American Indians with hereditary polymorphic light eruption (HPLE), or a family history of HPLE, had chronic, recurrent, exudative, and exfoliative cheilitis. Fifty-two had the cheilitis by the age of 10 years. Microscopically, the epithelium was either thickened, or thinned and covered by a thick crust. The dermis had a dense infiltration of inflammatory cells, mostly lymphocytes and plasma cells. The condition was not premalignant. The HPLE has to be differentiated from the chronic actinic cheilitis caused by long exposure to sunlight without any element of hypersensitivity. The latter is potentially premalignant. Chronic recurrent actinic cheilitis associated with hereditary polymorphic light eruption appears to be a specific characteristic of photosensitivity occurring in American Indians. Plasma cell infiltration is not specific for either type of cheilitis. (Arch Dermatol 115:699-702, 1979) References 1. Birt AR: Photodermatitis in Indians of Manitoba . Can Med Assoc J 98:392-397, 1968. 2. Birt AR, Davis RA: Photodermatitis in North American Indians: Familial actinic prurigo . Int J Dermatol 10:107-114, 1971.Crossref 3. Birt AR, Davis RA: Hereditary polymorphic light eruption of American Indians . Int J Dermatol 14:105-111, 1975.Crossref 4. Brandt R: Dermatological observations on the Navaho reservation . Arch Dermatol 77:581-585, 1958.Crossref 5. Schenck RR: Controlled trial of methoxsalen in solar dermatitis of Chippewa Indians . JAMA 172:1134-1137, 1960.Crossref 6. Londono F, Muvdi F, Giraldo F, et al: Familial actinic prurigo . Dermatol Ibero Latin Am 111:61-71, 1968. 7. Padilla HC: Cheilitis caused by photosensitization . Med Cutan Iber Latin Am 3:93-102, 1975. 8. Calnan CD, Meara RH: Actinic prurigo (Hutchinson's summer prurigo) . Clin Exp Dermatol 2:265-268, 1977.Crossref 9. Ramsay CA: Polymorphic light eruption , in Marks R, Samman PD (eds): Tutorials in Postgraduate Medicine . London, Heinemann, 1977, vol 6, p 454. 10. Ayres S Jr: Chronic actinic cheilitis . JAMA 81:1183-1186, 1923.Crossref 11. Gougerot H: Solar cheilitis . Bull Soc Fr Dermatol Syphilol 43:1592-1596, 1936. 12. Pashkov BM, Kutin SA: Pathogenesis, clinical symptoms and morphology of exfoliative cheilitis . Stomatologiia 52:11-13, 1973. 13. Jansen CT: Heredity of chronic polymorphous light eruptions . Arch Dermatol 114:188-190, 1978.Crossref 14. Schuermann H: Plasmocytosis circumorificialis . Dtsch Zahnaerztl Z 15:601-611, 1960. 15. Jillson OF: The persistent light reactors . Dermatol Dig 3:59-67, 1964.
Archives of Dermatology – American Medical Association
Published: Jun 1, 1979
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