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TETRAETHYLAMMONIUM CHLORIDE IN THE TREATMENT OF MULTIPLE SCLEROSIS

TETRAETHYLAMMONIUM CHLORIDE IN THE TREATMENT OF MULTIPLE SCLEROSIS Abstract OUR INTEREST in tetraethylammonium chloride was aroused quite by accident in August 1947. Tetraethylammonium chloride was used in an effort to relieve an intense causalgic state which had followed bilateral alcohol injection of the posterior tibial nerves in a case of multiple sclerosis with severe spasm of the plantar flexors of the feet. About two weeks after the beginning of therapy remarkable resolution of the long-standing paraplegia began. So dramatic was the improvement that an investigation of the possible role of tetraethylammonium chloride was considered necessary. Similarly suggestive results obtained in a second case of the disease treated shortly thereafter led us to undertake a more thorough evaluation of the drug in management of multiple sclerosis. Further impetus was given to the continuation of the study by the report of Bell, Williams and Karnosh.1 These workers found a favorable response in 14 acute cases and unfavorable results in 8 References 1. Bell, E.; Williams, G. H., and Karnosh, L. J.: Tetraethylammonium Chloride in Multiple Sclerosis , Cleveland Clin. Quart. 15:90, 1948.Crossref 2. Williams, G. H., and Bell, E.: Present Day Status of Multiple Sclerosis , Mississippi Doctor 27:130, 1949. 3. Franklin, C. R., and Brickner, R. M.: Vasospasm Associated with Multiple Sclerosis , Arch. Neurol. & Psychiat. 58:125 ( (Aug.) ) 1947. 4. Putnam, T. J.; Chiavacci, L. V.; Hoff, H., and Weitzen, H. G.: Results of Treatment of Multiple Sclerosis with Dicoumarin , Arch. Neurol. & Psychiat. 57:1 ( (Jan.) ) 1947. 5. Lyons, R. H., and others: The Effects of Blockade of the Autonomic Ganglia in Man with Tetraethylammonium Chloride , Am. J. M. Sc. 213:315, 1947. 6. Coller, F. A., and others: Tetra-Ethyl-Ammonium Chloride as an Adjunct in the Treatment of Peripheral Vascular Disease and Other Painful States , Ann. Surg. 125:729, 1947. 7. Lyons, R. H., and others: Experiences with Tetraethylammonium Chloride in Hypertension , J. A. M. A. 136:608 ( (Feb. 28) ) 1948. 8. Yeager, R. H.; Walker, J. H., and Raby, W. T.: Clinical Evaluation of Tetraethylammonium , South. M. J. 41:129, 1948. 9. Neligh, R. B., and others: The Effect of Blockade of Autonomic Ganglia by Tetraethylammonium Chloride in the Gastrointestinal Tract in Man , Proc. Am. Federation Clin. Research. 3:20, 1947. 10. Nesbit, R. M., and others: The Effects of Blockade of the Autonomic Ganglia on the Urinary Bladder in Man , J. Urol. 57:242, 1947. 11. Putnam, T. J.: The Criteria of Effective Treatment in Multiple Sclerosis , J. A. M. A. 112:2488 ( (June 17) ) 1939. 12. Langworthy, O. R.: Relation of Personality Problems to Onset and Progress of Multiple Sclerosis , Arch. Neurol. & Psychiat. 59:13 ( (Jan.) ) 1948. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

TETRAETHYLAMMONIUM CHLORIDE IN THE TREATMENT OF MULTIPLE SCLEROSIS

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Publisher
American Medical Association
Copyright
Copyright © 1950 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1950.02310280048005
Publisher site
See Article on Publisher Site

Abstract

Abstract OUR INTEREST in tetraethylammonium chloride was aroused quite by accident in August 1947. Tetraethylammonium chloride was used in an effort to relieve an intense causalgic state which had followed bilateral alcohol injection of the posterior tibial nerves in a case of multiple sclerosis with severe spasm of the plantar flexors of the feet. About two weeks after the beginning of therapy remarkable resolution of the long-standing paraplegia began. So dramatic was the improvement that an investigation of the possible role of tetraethylammonium chloride was considered necessary. Similarly suggestive results obtained in a second case of the disease treated shortly thereafter led us to undertake a more thorough evaluation of the drug in management of multiple sclerosis. Further impetus was given to the continuation of the study by the report of Bell, Williams and Karnosh.1 These workers found a favorable response in 14 acute cases and unfavorable results in 8 References 1. Bell, E.; Williams, G. H., and Karnosh, L. J.: Tetraethylammonium Chloride in Multiple Sclerosis , Cleveland Clin. Quart. 15:90, 1948.Crossref 2. Williams, G. H., and Bell, E.: Present Day Status of Multiple Sclerosis , Mississippi Doctor 27:130, 1949. 3. Franklin, C. R., and Brickner, R. M.: Vasospasm Associated with Multiple Sclerosis , Arch. Neurol. & Psychiat. 58:125 ( (Aug.) ) 1947. 4. Putnam, T. J.; Chiavacci, L. V.; Hoff, H., and Weitzen, H. G.: Results of Treatment of Multiple Sclerosis with Dicoumarin , Arch. Neurol. & Psychiat. 57:1 ( (Jan.) ) 1947. 5. Lyons, R. H., and others: The Effects of Blockade of the Autonomic Ganglia in Man with Tetraethylammonium Chloride , Am. J. M. Sc. 213:315, 1947. 6. Coller, F. A., and others: Tetra-Ethyl-Ammonium Chloride as an Adjunct in the Treatment of Peripheral Vascular Disease and Other Painful States , Ann. Surg. 125:729, 1947. 7. Lyons, R. H., and others: Experiences with Tetraethylammonium Chloride in Hypertension , J. A. M. A. 136:608 ( (Feb. 28) ) 1948. 8. Yeager, R. H.; Walker, J. H., and Raby, W. T.: Clinical Evaluation of Tetraethylammonium , South. M. J. 41:129, 1948. 9. Neligh, R. B., and others: The Effect of Blockade of Autonomic Ganglia by Tetraethylammonium Chloride in the Gastrointestinal Tract in Man , Proc. Am. Federation Clin. Research. 3:20, 1947. 10. Nesbit, R. M., and others: The Effects of Blockade of the Autonomic Ganglia on the Urinary Bladder in Man , J. Urol. 57:242, 1947. 11. Putnam, T. J.: The Criteria of Effective Treatment in Multiple Sclerosis , J. A. M. A. 112:2488 ( (June 17) ) 1939. 12. Langworthy, O. R.: Relation of Personality Problems to Onset and Progress of Multiple Sclerosis , Arch. Neurol. & Psychiat. 59:13 ( (Jan.) ) 1948.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Oct 1, 1950

References