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Testosterone and Male Aging

Testosterone and Male Aging Opinion EDITORIAL Faltering Hope for Rejuvenation David J. Handelsman, MB BS, PhD, FRACP, FAHMS Hopes for hormonal rejuvenation appear periodically through- letters and resulting in >50 000 telephone interviews) who out history—with the most prominent attempt occurring were 65 years or older with low circulating testosterone lev- around the turn of the 20th century only to vanish in the 1930s els for no apparent reason other than age (ie, excluding patho- following the discovery of testosterone, which discredited tes- logical hypogonadism) who were randomized to receive daily tis extracts and manipulations. In recent decades, there has testosterone transdermal gel or placebo gel for 12 months. Com- been a renewed attempt for hormonal rejuvenation with tes- pared with placebo, testosterone produced a modest in- tosterone in men. crease in sexual function (a 42% relative increase compared Today, 8 decades since the first clinical use of testosterone, with baseline) early in the study before waning by the end of the sole unequivocal indication for testosterone treatment is the study, but there was no objective benefit for physical func- as replacement therapy for men with pathological hypogo- tion or vitality. The authors concluded that the benefits for nadism (ie, organic disorders of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Testosterone and Male Aging

JAMA , Volume 317 (7) – Feb 21, 2017

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Publisher
American Medical Association
Copyright
Copyright 2017 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2017.0129
pmid
28241336
Publisher site
See Article on Publisher Site

Abstract

Opinion EDITORIAL Faltering Hope for Rejuvenation David J. Handelsman, MB BS, PhD, FRACP, FAHMS Hopes for hormonal rejuvenation appear periodically through- letters and resulting in >50 000 telephone interviews) who out history—with the most prominent attempt occurring were 65 years or older with low circulating testosterone lev- around the turn of the 20th century only to vanish in the 1930s els for no apparent reason other than age (ie, excluding patho- following the discovery of testosterone, which discredited tes- logical hypogonadism) who were randomized to receive daily tis extracts and manipulations. In recent decades, there has testosterone transdermal gel or placebo gel for 12 months. Com- been a renewed attempt for hormonal rejuvenation with tes- pared with placebo, testosterone produced a modest in- tosterone in men. crease in sexual function (a 42% relative increase compared Today, 8 decades since the first clinical use of testosterone, with baseline) early in the study before waning by the end of the sole unequivocal indication for testosterone treatment is the study, but there was no objective benefit for physical func- as replacement therapy for men with pathological hypogo- tion or vitality. The authors concluded that the benefits for nadism (ie, organic disorders of

Journal

JAMAAmerican Medical Association

Published: Feb 21, 2017

References