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Test Strip Meconium Screening for Cystic Fibrosis

Test Strip Meconium Screening for Cystic Fibrosis Abstract • The Boehringer-Mannheim Corporation (BMC) strip test is extremely reliable in indicating an albumin content above 20 mg/gm of dried meconium. All infants born during one year in 14 Milwaukee area hospitals were tested. Of 16,224 newborns, two were diagnosed correctly as suffering from cystic fibrosis and two were missed. False-positive tests were obtained in 0.9% of infants (prematurity, melena, gastroschisis, and intrauterine infection). The strip test is, at present, the best available but not the perfect screening method for cystic fibrosis. (Am J Dis Child 131:71-73, 1977) References 1. Green MA, Shwachman H: Presumptive tests for cystic fibrosis based on serum protein in meconium . Pediatrics 41:989-992, 1968. 2. Stephan U, Busch EW, Dannemann R: Ein neuer Screening-Test auf Mucoviscidose . Paediatr Prax 12:487-490, 1973. 3. Prosser R, Owen H, Bull F, et al: Screening for cystic fibrosis by examination of meconium . Arch Dis Child 49:597-601, 1974.Crossref 4. Stephan U, Busch EW, Kollberg H, et al: Cystic fibrosis detection by means of a test-strip . Pediatrics 55:35-38, 1975. 5. Kaiser D, Mariotti M, Rennert OM: Mucoviscidose bei negativem BM-Meconiumtest . Helv Paediatr Acta 29:51-54, 1974. 6. Kollberg H, Hellsing K: Screening for cystic fibrosis . Arch Dis Child 47:836, 1972.Crossref 7. Hellsing K, Kollberg H: Analysis of albumin in meconium for early detection of cystic fibrosis . Scand J Clin Lab Invest 33:333-340, 1974.Crossref 8. Frankenburg WK: Selection of diseases and tests in pediatric screening . Pediatrics 54:612-616, 1974. 9. North AF Jr: Screening in child health care: Where are we now and where are we going? Pediatrics 54:631-640, 1974. 10. Di Sant' Agnese PA: Cystic disease of the pancreas with normal or partial pancreatic function . Pediatrics 15:683-697, 1955. 11. Holtzman NA, Meek AG, Mellits ED: Neonatal screening for phenylketonuria: Factors influencing the occurrence of false positives . Am J Public Health 64:775-779, 1974.Crossref 12. Holtzman NA, Meek AG, Mellits ED: Neonatal screening for phenylketonuria: Effectiveness . JAMA 229:667-670, 1974.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Test Strip Meconium Screening for Cystic Fibrosis

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1977.02120140073013
Publisher site
See Article on Publisher Site

Abstract

Abstract • The Boehringer-Mannheim Corporation (BMC) strip test is extremely reliable in indicating an albumin content above 20 mg/gm of dried meconium. All infants born during one year in 14 Milwaukee area hospitals were tested. Of 16,224 newborns, two were diagnosed correctly as suffering from cystic fibrosis and two were missed. False-positive tests were obtained in 0.9% of infants (prematurity, melena, gastroschisis, and intrauterine infection). The strip test is, at present, the best available but not the perfect screening method for cystic fibrosis. (Am J Dis Child 131:71-73, 1977) References 1. Green MA, Shwachman H: Presumptive tests for cystic fibrosis based on serum protein in meconium . Pediatrics 41:989-992, 1968. 2. Stephan U, Busch EW, Dannemann R: Ein neuer Screening-Test auf Mucoviscidose . Paediatr Prax 12:487-490, 1973. 3. Prosser R, Owen H, Bull F, et al: Screening for cystic fibrosis by examination of meconium . Arch Dis Child 49:597-601, 1974.Crossref 4. Stephan U, Busch EW, Kollberg H, et al: Cystic fibrosis detection by means of a test-strip . Pediatrics 55:35-38, 1975. 5. Kaiser D, Mariotti M, Rennert OM: Mucoviscidose bei negativem BM-Meconiumtest . Helv Paediatr Acta 29:51-54, 1974. 6. Kollberg H, Hellsing K: Screening for cystic fibrosis . Arch Dis Child 47:836, 1972.Crossref 7. Hellsing K, Kollberg H: Analysis of albumin in meconium for early detection of cystic fibrosis . Scand J Clin Lab Invest 33:333-340, 1974.Crossref 8. Frankenburg WK: Selection of diseases and tests in pediatric screening . Pediatrics 54:612-616, 1974. 9. North AF Jr: Screening in child health care: Where are we now and where are we going? Pediatrics 54:631-640, 1974. 10. Di Sant' Agnese PA: Cystic disease of the pancreas with normal or partial pancreatic function . Pediatrics 15:683-697, 1955. 11. Holtzman NA, Meek AG, Mellits ED: Neonatal screening for phenylketonuria: Factors influencing the occurrence of false positives . Am J Public Health 64:775-779, 1974.Crossref 12. Holtzman NA, Meek AG, Mellits ED: Neonatal screening for phenylketonuria: Effectiveness . JAMA 229:667-670, 1974.Crossref

Journal

American Journal of Diseases of Children – American Medical Association

Published: Jan 1, 1977

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