Key PointsQuestionWhat are the cumulative incidence and temporal dynamics of acute cortical microinfarcts? FindingsIn this cohort study of 54 participants with cerebral small vessel disease who were recruited to undergo 10 monthly 3-T magnetic resonance imaging (MRI) scans, including high-resolution diffusion-weighted imaging, 21 acute cortical microinfarcts were observed in 7 of 54 participants (13%). All acute cortical microinfarcts disappeared on follow-up MRI. MeaningWe show that incident acute cortical microinfarcts never evolved into chronically MRI-detectable lesions and suggest that these acute microinfarcts underlie part of the submillimeter cortical microinfarcts visible only on neuropathology, thereby providing a source for the high microinfarct burden encountered on neuropathology.
JAMA Neurology – American Medical Association
Published: May 17, 2020