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Temporal Dynamics of Cortical Microinfarcts in Cerebral Small Vessel Disease

Temporal Dynamics of Cortical Microinfarcts in Cerebral Small Vessel Disease Key PointsQuestionWhat are the cumulative incidence and temporal dynamics of acute cortical microinfarcts? FindingsIn this cohort study of 54 participants with cerebral small vessel disease who were recruited to undergo 10 monthly 3-T magnetic resonance imaging (MRI) scans, including high-resolution diffusion-weighted imaging, 21 acute cortical microinfarcts were observed in 7 of 54 participants (13%). All acute cortical microinfarcts disappeared on follow-up MRI. MeaningWe show that incident acute cortical microinfarcts never evolved into chronically MRI-detectable lesions and suggest that these acute microinfarcts underlie part of the submillimeter cortical microinfarcts visible only on neuropathology, thereby providing a source for the high microinfarct burden encountered on neuropathology. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2020 American Medical Association. All Rights Reserved.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/jamaneurol.2019.5106
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionWhat are the cumulative incidence and temporal dynamics of acute cortical microinfarcts? FindingsIn this cohort study of 54 participants with cerebral small vessel disease who were recruited to undergo 10 monthly 3-T magnetic resonance imaging (MRI) scans, including high-resolution diffusion-weighted imaging, 21 acute cortical microinfarcts were observed in 7 of 54 participants (13%). All acute cortical microinfarcts disappeared on follow-up MRI. MeaningWe show that incident acute cortical microinfarcts never evolved into chronically MRI-detectable lesions and suggest that these acute microinfarcts underlie part of the submillimeter cortical microinfarcts visible only on neuropathology, thereby providing a source for the high microinfarct burden encountered on neuropathology.

Journal

JAMA NeurologyAmerican Medical Association

Published: May 17, 2020

References