Abstract INTRATUMOR injection of radioactive colloidal gold as a means of sharply localizing radiation within tumors was proposed in 1947 by P. F. Hahn.1 Perhaps the main reason that widespread clinical use has not yet been made of this form of therapy is the technical difficulty of (1) insuring an even dispersion of the radioactive solution throughout the tumor, and (2) preventing the therapist from receiving hazardous amounts of radiation when he is working with high levels of activity. These technical problems can largely be overcome by use of the special equipment and techniques which are described in this paper. PHYSICAL PROPERTIES OF AU198 Au198 is produced from the stable isotope Au197 by neutron bombardment in the chain-reacting pile at Oak Ridge. Since Au197 has a high cross section capture for neutrons (100 barns), the production of Au198 is reasonably efficient, and a high specific activity References 1. Hahn, P. F.; Goodell, J. P. B.; Sheppard, C. W.; Cannon, R. O., and Francis, H. C.: Direct Infiltration of Radioactive Isotopes as a Means of Delivering Ionizing Radiation to Discrete Tissues , J. Lab. & Clin. Med. 32:1442-1453, 1947. 2. Gleason, G. I., and Tabern, D. L.: Preliminary Manual of the Properties and Uses of Colloidal Gold198 , North Chicago, Ill., Abbott Laboratories, 1951. 3. Marinelli, L. D.; Quimby, E. H., and Hine, G. J.: Dosage Determination with Radioactive Isotopes: II. Practical Considerations in Therapy and Protection , Am. J. Roentgenol. 59:260-281, 1948. 4. Radioactive colloidal gold may be obtained commercially from Abbott Laboratories, North Chicago, Ill., by investigators with allocations from the Atomic Energy Commission. Address inquiries to Dr. D. L. Tabern, Head, Special Research. 5. Hahn, P. F.: A Manual of Artificial Radioisotope Therapy , New York, Academic Press, 1951, Chap. 9 . 6. Polyvinylene tubing can be obtained from the Irvington Varnish and Insulator Co., Irvington, N. J. 7. An equivalent roentgen (abbreviated e. r.) is "that amount of beta radiation which, under equilibrium conditions, releases in one gram of air as much energy as one roentgen of gamma rays." 3 8. Wheeler, H. B.; Botsford, T. W.; Rubenstein, J. H.; Coleman, M. D., and Moore, F. D.: Treatment of Inoperable Neoplasms by Intratumor Injection of Radioactive Colloidal Gold: A Preliminary Report, to be published. 9. As defined at the Permissible Doses Conference of the radiation protection committees of the United States, Great Britain, and Canada, held at Chalk River, Ont., Canada, Sept. 29-30, 1949. 10. Wheeler, H. B.; Jackson, M. A., and Hahn, P. F.: Hematology of the Dog Following Intravenous Administration of Radioactive Colloidal Gold , Am. J. Physiol. 166, (2) :323-327, 1951. 11. Ter-Pogossian, M., and Sherman, A. I.: Handling of Radioactive Gold for Therapeutic Purposes , Nucleonics 10(No. (3) ):23-27, 1952.
A.M.A. Archives Surgery – American Medical Association
Published: Aug 1, 1952
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