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Technique Has Advantages Of Hypothermia, Perfusion

Technique Has Advantages Of Hypothermia, Perfusion Functional renal homografts have been obtained as long as 14 hours postmortem by the medical group working with transplantation procedures at the University of Colorado School of Medicine and the Denver VA Hospital. The technique they use incorporates the advantages of both hypothermia and perfusion. In addition to two cadaveric renal transplantations, the four liver transplantations performed recently by the group afforded an opportunity for clinical application of the technique. In earlier experimental trials, dogs were sacrificed after aortic and inferior vena caval catheters had been inserted through the femoral artery and vein. The catheters were connected to an extracorporeal perfusion system consisting of a disposable bubble oxygenator, a single DeBakey pump, and a heat exchanger. Venous outflow was by gravity drainage. The oxygenator was primed with lactated Ringer's solution in all experiments except two hepatic transplants in which 5% dextrose in water was used. The perfusate was precooled to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Technique Has Advantages Of Hypothermia, Perfusion

JAMA , Volume 185 (9) – Aug 31, 1963
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Technique Has Advantages Of Hypothermia, Perfusion

Abstract


Functional renal homografts have been obtained as long as 14 hours postmortem by the medical group working with transplantation procedures at the University of Colorado School of Medicine and the Denver VA Hospital.
The technique they use incorporates the advantages of both hypothermia and perfusion. In addition to two cadaveric renal transplantations, the four liver transplantations performed recently by the group afforded an opportunity for clinical application of the...
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Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1963.03060090016007
Publisher site
See Article on Publisher Site

Abstract

Functional renal homografts have been obtained as long as 14 hours postmortem by the medical group working with transplantation procedures at the University of Colorado School of Medicine and the Denver VA Hospital. The technique they use incorporates the advantages of both hypothermia and perfusion. In addition to two cadaveric renal transplantations, the four liver transplantations performed recently by the group afforded an opportunity for clinical application of the technique. In earlier experimental trials, dogs were sacrificed after aortic and inferior vena caval catheters had been inserted through the femoral artery and vein. The catheters were connected to an extracorporeal perfusion system consisting of a disposable bubble oxygenator, a single DeBakey pump, and a heat exchanger. Venous outflow was by gravity drainage. The oxygenator was primed with lactated Ringer's solution in all experiments except two hepatic transplants in which 5% dextrose in water was used. The perfusate was precooled to

Journal

JAMA – American Medical Association

Published: Aug 31, 1963

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