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TB Vaccine

TB Vaccine Older versions of the bacille Calmette-Guérin (BCG) vaccine used to immunize against tuberculosis may be more effective than some of the more recent strains, according to a new study by French researchers (Brosch R et al. Proc Natl Acad Sci U S A. doi:10.1073/pnas.0700869104 [published online ahead of print March 19, 2007]). The BCG vaccine has been in use since the early 1900s; the researchers speculated that various daughter strains derived from this source have accumulated genetic mutations affect immunogenicity. When they compared the genomes of different BCG daughter strains, they found extensive genetic changes, especially in newer strains, that could compromise the vaccine's efficacy. They also noted that a 2006 study found that newborns vaccinated with BCG Japan, an “early” strain, had more powerful immune responses than newborns vaccinated with a “late” strain, BCG Danish (Davids V et al. J Infect Dis. 2006;193:531-536). “Taken together with our findings, this suggests that early BCG vaccines may confer better protection against tuberculosis, a possibility that would benefit from formal evaluation in clinical trials,” the researchers concluded. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

TB Vaccine

Stephenson, Joan
JAMA , Volume 297 (15) – Apr 18, 2007
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TB Vaccine

Abstract

Older versions of the bacille Calmette-Guérin (BCG) vaccine used to immunize against tuberculosis may be more effective than some of the more recent strains, according to a new study by French researchers (Brosch R et al. Proc Natl Acad Sci U S A. doi:10.1073/pnas.0700869104 [published online ahead of print March 19, 2007]). The BCG vaccine has been in use since the early 1900s; the researchers speculated that various daughter strains derived from this source have accumulated genetic...
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Publisher
American Medical Association
Copyright
Copyright © 2007 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.297.15.1646-c
Publisher site
See Article on Publisher Site

Abstract

Older versions of the bacille Calmette-Guérin (BCG) vaccine used to immunize against tuberculosis may be more effective than some of the more recent strains, according to a new study by French researchers (Brosch R et al. Proc Natl Acad Sci U S A. doi:10.1073/pnas.0700869104 [published online ahead of print March 19, 2007]). The BCG vaccine has been in use since the early 1900s; the researchers speculated that various daughter strains derived from this source have accumulated genetic mutations affect immunogenicity. When they compared the genomes of different BCG daughter strains, they found extensive genetic changes, especially in newer strains, that could compromise the vaccine's efficacy. They also noted that a 2006 study found that newborns vaccinated with BCG Japan, an “early” strain, had more powerful immune responses than newborns vaccinated with a “late” strain, BCG Danish (Davids V et al. J Infect Dis. 2006;193:531-536). “Taken together with our findings, this suggests that early BCG vaccines may confer better protection against tuberculosis, a possibility that would benefit from formal evaluation in clinical trials,” the researchers concluded.

Journal

JAMA – American Medical Association

Published: Apr 18, 2007

Keywords: tuberculosis vaccines

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