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J. Vaidya, M. Bulsara, C. Saunders, H. Flyger, J. Tobias, T. Corica, S. Massarut, F. Wenz, S. Pigorsch, M. Alvarado, M. Douek, W. Eiermann, C. Brew-Graves, N. Williams, I. Potyka, Nicholas Roberts, Marcelle Bernstein, Douglas Brown, E. Sperk, S. Laws, M. Sütterlin, S. Lundgren, D. Holmes, L. Vinante, F. Bozza, M. Pazos, M. Blanc-Onfroy, G. Gruber, W. Polkowski, K. Dedes, M. Niewald, J. Blohmer, D. McCready, R. Hoefer, P. Kelemen, G. Petralia, M. Falzon, M. Baum, D. Joseph (2020)
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Letters proportion score. The modification in using modified propor- Targeted Intraoperative Radiotherapy tion score is that mononuclear inflammatory cells that ex- for Early Breast Cancer press PD-L1 are counted in conjunction with the tumor cells, To the Editor We read with interest the report on the long-term and only tumor nests are scored for PD-L1 positivity, while the recurrence and survival outcomes after treatment with de- tumor-associated stroma is excluded. Scoring in our study for layed second-procedure targeted intraoperative radio- PD-L1 expression used the Dako 22C3 antibody. In contrast, the therapy (IORT) vs whole-breast radiotherapy by Vaidya et al. combined proportion score grades both tumor cells and mono- Since the publication of 5-year outcomes from the TARGIT-A nuclear inflammatory cells within tumor nests as well as tumor- trial, the oncology community has awaited long-term out- associated stroma. The Dako 22C3 test (Agilent Technolo- comes from the study to evaluate the utility of IORT for early gies) uses tumor proportion score and scores only reactive breast cancer. The recent publication of the delayed- tumor cells for PD-L1 in the commercially approved NSCLC treatment cohort of patients from the TARGIT-A trial has now indication. provided additional information. The study found that
JAMA Oncology – American Medical Association
Published: Oct 13, 2020
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