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Tamoxifen Flare

Tamoxifen Flare To the Editor.— We have read the article by Plotkin et al in The Journal (240:2644, 1979) regarding a flare from tamoxifen used in patients with breast cancer. We have also experienced this complication in greater numbers than earlier information suggested. As Plotkin and associates point out, the increased, sometimes excruciating pain occurs within the first seven to ten days of use and often will lead to discontinuation either by the patient or by the physician. Our first several patients who experienced this flare were given steroid therapy, usually prednisone, 5 to 10 mg/day for seven to ten days. Even with continuation of the tamoxifen, the patients' pain quickly abated, and they were able to resume their previous activity and improve their activity level. They had a remission from the tamoxifen. We are not sure how the steroid affects the tamoxifen flare; it could be that the patients who respond http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Tamoxifen Flare

JAMA , Volume 242 (1) – Jul 6, 1979

Tamoxifen Flare

Abstract



To the Editor.—
We have read the article by Plotkin et al in The Journal (240:2644, 1979) regarding a flare from tamoxifen used in patients with breast cancer. We have also experienced this complication in greater numbers than earlier information suggested.
As Plotkin and associates point out, the increased, sometimes excruciating pain occurs within the first seven to ten days of use and often will lead to discontinuation either by the patient or by the physician.
Our first several...
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Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1979.03300010019014
Publisher site
See Article on Publisher Site

Abstract

To the Editor.— We have read the article by Plotkin et al in The Journal (240:2644, 1979) regarding a flare from tamoxifen used in patients with breast cancer. We have also experienced this complication in greater numbers than earlier information suggested. As Plotkin and associates point out, the increased, sometimes excruciating pain occurs within the first seven to ten days of use and often will lead to discontinuation either by the patient or by the physician. Our first several patients who experienced this flare were given steroid therapy, usually prednisone, 5 to 10 mg/day for seven to ten days. Even with continuation of the tamoxifen, the patients' pain quickly abated, and they were able to resume their previous activity and improve their activity level. They had a remission from the tamoxifen. We are not sure how the steroid affects the tamoxifen flare; it could be that the patients who respond

Journal

JAMAAmerican Medical Association

Published: Jul 6, 1979

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