Abstract • Acute tolerance to the vasoconstrictive effect of topically applied glucocorticoids in humans has recently been described. Similar acute tolerance to the antiproliferative properties of topically applied steroids in proliferating and normal hairless mouse epidermis is now shown to occur. Thus, at first, topically applied steroids cause profound inhibition of DNA synthesis and mitosis in the epidermis, but with continued treatment, DNA synthesis and mitosis recover and the tissue becomes insensitive to further stimulation. This suggests that there is an optimum approach to therapy with topically applied steroids that might reduce the incidence of side effects and improve therapeutic efficacy. (Arch Dermatol 112:1245-1248, 1976) References 1. du Vivier A, Stoughton RB: Tachyphylaxis to the action of topically applied corticosteroids . Arch Dermatol 111:581-583, 1975.Crossref 2. McKenzie AW: Percutaneous absorption of steroids . Arch Dermatol 86:611-614, 1962.Crossref 3. McKenzie AW, Atkinson RM: Topical activities of betamethasone esters in man . Arch Dermatol 89:741-746, 1964.Crossref 4. Stoughton RB: Status of topical therapy . Clin Pharmacol Ther 16:869-872, 1974. 5. Fisher LB, Maibach HI: The effect of corticosteroids on human epidermal mitotic activity . Arch Dermatol 103:39-44, 1971.Crossref 6. Baxter D, Stoughton RB: Mitotic index of psoriatic lesions treated with anthralin, glucocorticosteroid and occlusion only . J Invest Dermatol 54:410-412, 1970.Crossref 7. du Vivier A, Stoughton RB: An animal model for screening topical and systemic drugs for potential use in the treatment of psoriasis . J Invest Dermatol 65:235-237, 1975.Crossref 8. du Vivier A, Bible R, Mikuriya R, et al: An animal model for screening drugs for antipsoriatic properties using hydroxyapatite to rapidly isolate DNA from the epidermis . Br J Dermatol 94:1-6, 1976.Crossref 9. Felsenfeld G, Hischman SZ: A neighborinteraction analysis of hypochromism and spectra of DNA . J Mol Biol 13:407-427, 1965.Crossref 10. Epstein NN, Epstein WL, Epstein JH: Atrophic striae in patients with inguinal intertrigo: Pathogenesis . Arch Dermatol 87:450-457, 1963.Crossref 11. Ive FA, Marks R: Tinea incognito . Br Med J 3:149-153, 1968.Crossref 12. Sneddon IB: Adverse effects of topical fluorinated corticosteroids in rosacea . Br Med J 1:671-673, 1969. 13. Munro DD, Clift DC: Pituitary-adrenal function after prolonged use of topical corticosteroids . Br J Dermatol 88:381-385, 1973.Crossref 14. Wilson L, Williams DI, Marsh SD: Plasma corticosteroid levels in out patients treated with topical steroids . Br J Dermatol 88:373-380, 1973.Crossref 15. Feiwel M, James VHT, Barnett ES: Effect of potent topical steroids on plasma cortisol levels of infants and children with eczema . Lancet 1:485-487, 1969.Crossref 16. Finn CA, Martin L, Carter J: A refractory period following oestrogen stimulation of cell division in the mouse uterus . J Endocrinol 44:121-126, 1969.Crossref 17. Sheppard H, Tsien WH, Mayer P, et al: Metabolism of the accessory sex organs of the immature male rat: Changes in nucleic acid composition and uptake of thymidine-3H induced by castration and methandrostenoline . Biochem Pharmacol 14:41-51, 1965.Crossref 18. Epifanova OI: Effects of hormones on the cell cycle , in Baserga R (ed): The Cell Cycle and Cancer . New York, Marcel Dekker Inc, 1971, pp 143-190. 19. Teir H, Isotalo A: Influence of cortisone on mitosis: I. Effect of single dose and prolonged application . Ann Med Exp Biol Fenn 31:171-180, 1953. 20. Bullough WS: Mitotic and functional homeostasis: A speculative review . Cancer Res 25:1683-1727, 1965.
Archives of Dermatology – American Medical Association
Published: Sep 1, 1976