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T3 Thyrotoxicosis in a Child

T3 Thyrotoxicosis in a Child Abstract • We report the case of a 5-year-old hyperthyroid boy with normal serum T4 levels and elevated serum T3 levels. The findings are diagnostic of T3 thyrotoxicosis, a condition that has been very infrequently reported in childhood. We postulate that low dietary iodine intake may be an etiologic factor in some cases of T3 thyrotoxicosis. (Am J Dis Child 132:374-375, 1978) References 1. Maclagan NF, Bowden CH, Wilkinson LH: The metabolism of thyroid hormone: 2. Detection of thyroxine and triiodothyronine in human plasma . Biochem J 67:5-11, 1957. 2. Hollander CS: On the nature of the circulating thyroid hormones: Clinical studies of triiodothyronine and thyroxine in serum using gas chromatographic methods . Trans Assoc Am Physicians 81:76-89, 1968. 3. Gharib H, Mayberry WE, Ryan RJ: Radioimmunoassay for triiodothyronine: A preliminary report . J Clin Endocrinol Metab 31:709-712, 1970.Crossref 4. Popma BH, Cloutier MD, Hayles AB: Thyroid nodule producing T3 toxicosis in a child . Mayo Clin Proc 48:273-275, 1973. 5. Colantonio LA, Orson JM: Triiodothyronine thyrotoxicosis . Am J Dis Child 128:396-397, 1974. 6. Jacobs HS, Eastman CJ, Ekins RP et al: Thyroid storm and recurrent hyperthyroidism . Lancet 2:236-238, 1973.Crossref 7. Mitsuma T, Owens R, Shenkman L, et al: T3 toxicosis in childhood: Hyperthyroidism due to isolated hypersecretion of triiodothyronine . J Pediatr 81:982-984, 1972.Crossref 8. Wahner HW: T3 hyperthyroidism . Mayo Clin Proc 47:938-943, 1972. 9. Gharib H, Wahner HW, McConahey WM: Serum levels of thyroid hormones in Hashimoto's thyroiditis . Mayo Clin Proc 47:175-179, 1972. 10. Av Ruskin TW, Tang S, Shenkman L, et al: T3 toxicosis in adolescence: Presentation as recurrent hyperthyroidism . Pediatrics 5:649-652, 1973. 11. Hesch RD, Müblen AVZ, Hüfner M, et al: Hypertriiodothyronemia . Acta Endocr (Suppl) 173:17, 1973. 12. Shalet SM, Beardwell CG, Lamb AM, et al: Value of routine serum triiodothyronine estimation in diagnosis of thyrotoxicosis . Lancet 2:1008-1010, 1975.Crossref 13. Carter JN, Eastman CJ, Casey JH, et al: Triiodothyronine thyrotoxicosis . Med J Aust 1:229-233, 1975. 14. Hollander CS, Stevenson C, Mitsuma T, et al: T3 toxicosis: Association with iodine deficiency . Clin Res 20:623, 1972. 15. Hollander CS, Mitsuma T, Shenkman L, et al: T3 toxicosis in an iodine deficient area . Lancet 2:1276, 1972.Crossref 16. Greer MA, Grimm Y, Studer H: Qualitative changes in secretion of thyroid hormones induced by iodine deficiency . Endocrinology 83:1193-1198, 1968.Crossref 17. Ingbar SH: Autoregulation of the thyroid: Response to iodine excess and depletion . Mayo Clin Proc 47:814-823, 1972. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1978.02120290046007
Publisher site
See Article on Publisher Site

Abstract

Abstract • We report the case of a 5-year-old hyperthyroid boy with normal serum T4 levels and elevated serum T3 levels. The findings are diagnostic of T3 thyrotoxicosis, a condition that has been very infrequently reported in childhood. We postulate that low dietary iodine intake may be an etiologic factor in some cases of T3 thyrotoxicosis. (Am J Dis Child 132:374-375, 1978) References 1. Maclagan NF, Bowden CH, Wilkinson LH: The metabolism of thyroid hormone: 2. Detection of thyroxine and triiodothyronine in human plasma . Biochem J 67:5-11, 1957. 2. Hollander CS: On the nature of the circulating thyroid hormones: Clinical studies of triiodothyronine and thyroxine in serum using gas chromatographic methods . Trans Assoc Am Physicians 81:76-89, 1968. 3. Gharib H, Mayberry WE, Ryan RJ: Radioimmunoassay for triiodothyronine: A preliminary report . J Clin Endocrinol Metab 31:709-712, 1970.Crossref 4. Popma BH, Cloutier MD, Hayles AB: Thyroid nodule producing T3 toxicosis in a child . Mayo Clin Proc 48:273-275, 1973. 5. Colantonio LA, Orson JM: Triiodothyronine thyrotoxicosis . Am J Dis Child 128:396-397, 1974. 6. Jacobs HS, Eastman CJ, Ekins RP et al: Thyroid storm and recurrent hyperthyroidism . Lancet 2:236-238, 1973.Crossref 7. Mitsuma T, Owens R, Shenkman L, et al: T3 toxicosis in childhood: Hyperthyroidism due to isolated hypersecretion of triiodothyronine . J Pediatr 81:982-984, 1972.Crossref 8. Wahner HW: T3 hyperthyroidism . Mayo Clin Proc 47:938-943, 1972. 9. Gharib H, Wahner HW, McConahey WM: Serum levels of thyroid hormones in Hashimoto's thyroiditis . Mayo Clin Proc 47:175-179, 1972. 10. Av Ruskin TW, Tang S, Shenkman L, et al: T3 toxicosis in adolescence: Presentation as recurrent hyperthyroidism . Pediatrics 5:649-652, 1973. 11. Hesch RD, Müblen AVZ, Hüfner M, et al: Hypertriiodothyronemia . Acta Endocr (Suppl) 173:17, 1973. 12. Shalet SM, Beardwell CG, Lamb AM, et al: Value of routine serum triiodothyronine estimation in diagnosis of thyrotoxicosis . Lancet 2:1008-1010, 1975.Crossref 13. Carter JN, Eastman CJ, Casey JH, et al: Triiodothyronine thyrotoxicosis . Med J Aust 1:229-233, 1975. 14. Hollander CS, Stevenson C, Mitsuma T, et al: T3 toxicosis: Association with iodine deficiency . Clin Res 20:623, 1972. 15. Hollander CS, Mitsuma T, Shenkman L, et al: T3 toxicosis in an iodine deficient area . Lancet 2:1276, 1972.Crossref 16. Greer MA, Grimm Y, Studer H: Qualitative changes in secretion of thyroid hormones induced by iodine deficiency . Endocrinology 83:1193-1198, 1968.Crossref 17. Ingbar SH: Autoregulation of the thyroid: Response to iodine excess and depletion . Mayo Clin Proc 47:814-823, 1972.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Apr 1, 1978

References