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T3 Thyrotoxicosis

T3 Thyrotoxicosis Abstract Sir.—Reporting a case of T3 thyrotoxicosis in a child, Weiss et al (132:374-375, 1978) postulated that in pediatric patients the disease may be more common than indicated by the few reported cases. We have had the opportunity to study a T3 toxicosis in a 10-year-old girl with diffuse goiter and exophthalmus. Thyroid studies showed normal serum thyroxine (T4) level, raised serum triiodothyronine (T3) level, raised uptake of radioactive iodine by thyroid, and absence of serum thyroid-stimulating hormone response to thyrotrophin-releasing hormone.1 In spite of the fact that both low or high iodide ingestion have been reported as an etiologic factor in some cases of T3 thyrotoxicosis, a detailed dietary history did not disclose data to support such an etiology in our patient. Poor iodination of thyroglobulin,2 interference in the peripherical conversion of T4 to T3,3 or the presence of thyroidstimulating References 1. Pombo M, Martinón JM, Pereira J, et al: Toxicosis T, en una niña . Endocrinología , to be published. 2. Harland PC, McArthur RG, Fawcett DM: T, toxicosis in children . Acta Paediatr Scand 66:525-528, 1977.Crossref 3. Chopra IJ: An assessment of daily production and significance of thyroidal secretion of 3,3′,5′-triiodothyronine (reverse T3) in man . J Clin Invest 58:32, 1976.Crossref 4. Hall R, Besser GM: Endocrine function , in Latner AL (ed): Cantarow and Trumper Clinical Biochemistry , ed 7. Philadelphia, WB Saunders Co, 1975, p 766. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

T3 Thyrotoxicosis

Abstract

Abstract Sir.—Reporting a case of T3 thyrotoxicosis in a child, Weiss et al (132:374-375, 1978) postulated that in pediatric patients the disease may be more common than indicated by the few reported cases. We have had the opportunity to study a T3 toxicosis in a 10-year-old girl with diffuse goiter and exophthalmus. Thyroid studies showed normal serum thyroxine (T4) level, raised serum triiodothyronine (T3) level, raised uptake of radioactive iodine by thyroid, and absence of serum...
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Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1978.02120360103024
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—Reporting a case of T3 thyrotoxicosis in a child, Weiss et al (132:374-375, 1978) postulated that in pediatric patients the disease may be more common than indicated by the few reported cases. We have had the opportunity to study a T3 toxicosis in a 10-year-old girl with diffuse goiter and exophthalmus. Thyroid studies showed normal serum thyroxine (T4) level, raised serum triiodothyronine (T3) level, raised uptake of radioactive iodine by thyroid, and absence of serum thyroid-stimulating hormone response to thyrotrophin-releasing hormone.1 In spite of the fact that both low or high iodide ingestion have been reported as an etiologic factor in some cases of T3 thyrotoxicosis, a detailed dietary history did not disclose data to support such an etiology in our patient. Poor iodination of thyroglobulin,2 interference in the peripherical conversion of T4 to T3,3 or the presence of thyroidstimulating References 1. Pombo M, Martinón JM, Pereira J, et al: Toxicosis T, en una niña . Endocrinología , to be published. 2. Harland PC, McArthur RG, Fawcett DM: T, toxicosis in children . Acta Paediatr Scand 66:525-528, 1977.Crossref 3. Chopra IJ: An assessment of daily production and significance of thyroidal secretion of 3,3′,5′-triiodothyronine (reverse T3) in man . J Clin Invest 58:32, 1976.Crossref 4. Hall R, Besser GM: Endocrine function , in Latner AL (ed): Cantarow and Trumper Clinical Biochemistry , ed 7. Philadelphia, WB Saunders Co, 1975, p 766.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Nov 1, 1978

References