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T-lymphocytes and Survival of Head and Neck Squamous Cell Carcinoma

T-lymphocytes and Survival of Head and Neck Squamous Cell Carcinoma Abstract • The thymus-dependent lymphocytes (T cells) were enumerated in the peripheral circulation of 38 patients with histologically demonstrated squamous cell carcinoma of the head and neck. We have previously shown that this "total" T-cell count correlates well with degree of tumor involvement. A lower percentage of T cells were shown in patients with more advanced malignant neoplasms. Here we present follow-up data on these patients to evaluate the efficiency of the T-cell test in determining survival prognoses. We found no evidence that results of this test can extend prognostic abilities above those based on clinical staging. The survival data from six patients treated with a chemoimmunotherapy regimen of BCG vaccine, methotrexate sodium, and isoniazid did not demonstrate an increased survival time compared to patients at similar clinical stages who were treated by conventional use of surgery and irradiation. (Arch Otolaryngol 103:223-227, 1977) References 1. Craddock CG, Longmire R, McMillan R: Lymphocytes and the immune response: I . N Engl J Med 285:324-331, 1971.Crossref 2. Craddock CG, Longmire R, McMillan R: Lymphocytes and the immune response: II . N Engl J Med 285:378-384, 1972.Crossref 3. Eilber FR, Morton DL: Impaired immunologic activity and recurrence following cancer surgery . Cancer 25:362-367, 1970.Crossref 4. Catalona WJ, Sample WF, Chretien PB: Lymphocyte reactivity in cancer patients: Correlation with tumor histology and clinical stage . Cancer 31:65-71, 1973.Crossref 5. Catalona WJ, Chretien PB: Abnormalities of quantitative dinitrochlorobenzene sensitization in cancer patients: Correlation with tumor stage and histology . Cancer 31:353-356, 1973.Crossref 6. Maisel RH, Ogura JH: Abnormal dinitrochlorobenzene skin sensitization: A prognostic sign of survival in head and neck squamous cell carcinoma . Laryngoscope 83:2012-2019, 1973.Crossref 7. Mandel MA, Kiehm CL: The significance of delayed cutaneous reactivity in head and neck cancer patients . Plast Reconstr Surg 53:72-76, 1974.Crossref 8. Chakravorty RC, Curutchet HP, Coppolla FS, et al: The delayed hypersensitivity reactivity reaction in the cancer patient: Observations on sensitization by DNCB . Surgery 73:730-735, 1973. 9. Chretien PB, Crowder WL, Gertner HR, et al: Correlation of pre-operative lymphocyte reactivity with the clinical course of cancer patients . Surg Gynecol Obstet 136:380-384, 1973. 10. Twomey PL, Catalona WJ, Chretien PB: Cellular immunity in cured cancer patients . Cancer 33:435-440, 1974.Crossref 11. Eastham RJ, Mason JM, Jennings BR, et al: T-cell rosette test in squamous cell carcinoma of the head and neck . Arch Otolaryngol 102:171-175, 1975.Crossref 12. Olkowski ZL, Wilkins SA: T-lymphocyte levels in the peripheral blood of patients with cancer of the head and neck . Am J Surg 130:440-444, 1975.Crossref 13. Wanebo HJ, Jun MY, Strong EW, et al: T-cell deficiency in patients with squamous cell cancer of the head and neck . Am J Surg 130:445-451, 1975.Crossref 14. Stefano S, Kerman R, Abbate J: Serial studies of immunocompetence in head and neck cancer patients undergoing radiation therapy . Am J Roentgenol Radium Ther Nucl Med 126:880-886, 1976.Crossref 15. Wybran J, Fudenberg HH: Thymusderived rosette-forming cells in various human disease states: Cancer, lymphoma, bacterial and viral infections, and other disease . J Clin Invest 52:1026-1032, 1973.Crossref 16. Niklasson PM, Williams RC Jr: Studies of peripheral blood T- and B-lymphocytes in acute infections . Infect Immun 9:1-7, 1974. 17. Wybran J, Fudenberg HH: Rosette formation: A test for cellular immunity . Trans Assoc Am Physicians 84:239-245, 1971. 18. Donaldson RC: Methotrexate plus bacillus Calmette-Guerin (BCG) and isoniazid in the treatment of cancer of the head and neck . Am J Surg 124:527-534, 1972.Crossref 19. Donaldson RC: Chemoimmunotherapy for cancer of the head and neck . Am J Surg 126:507-512, 1973.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

T-lymphocytes and Survival of Head and Neck Squamous Cell Carcinoma

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Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1977.00780210079009
Publisher site
See Article on Publisher Site

Abstract

Abstract • The thymus-dependent lymphocytes (T cells) were enumerated in the peripheral circulation of 38 patients with histologically demonstrated squamous cell carcinoma of the head and neck. We have previously shown that this "total" T-cell count correlates well with degree of tumor involvement. A lower percentage of T cells were shown in patients with more advanced malignant neoplasms. Here we present follow-up data on these patients to evaluate the efficiency of the T-cell test in determining survival prognoses. We found no evidence that results of this test can extend prognostic abilities above those based on clinical staging. The survival data from six patients treated with a chemoimmunotherapy regimen of BCG vaccine, methotrexate sodium, and isoniazid did not demonstrate an increased survival time compared to patients at similar clinical stages who were treated by conventional use of surgery and irradiation. (Arch Otolaryngol 103:223-227, 1977) References 1. Craddock CG, Longmire R, McMillan R: Lymphocytes and the immune response: I . N Engl J Med 285:324-331, 1971.Crossref 2. Craddock CG, Longmire R, McMillan R: Lymphocytes and the immune response: II . N Engl J Med 285:378-384, 1972.Crossref 3. Eilber FR, Morton DL: Impaired immunologic activity and recurrence following cancer surgery . Cancer 25:362-367, 1970.Crossref 4. Catalona WJ, Sample WF, Chretien PB: Lymphocyte reactivity in cancer patients: Correlation with tumor histology and clinical stage . Cancer 31:65-71, 1973.Crossref 5. Catalona WJ, Chretien PB: Abnormalities of quantitative dinitrochlorobenzene sensitization in cancer patients: Correlation with tumor stage and histology . Cancer 31:353-356, 1973.Crossref 6. Maisel RH, Ogura JH: Abnormal dinitrochlorobenzene skin sensitization: A prognostic sign of survival in head and neck squamous cell carcinoma . Laryngoscope 83:2012-2019, 1973.Crossref 7. Mandel MA, Kiehm CL: The significance of delayed cutaneous reactivity in head and neck cancer patients . Plast Reconstr Surg 53:72-76, 1974.Crossref 8. Chakravorty RC, Curutchet HP, Coppolla FS, et al: The delayed hypersensitivity reactivity reaction in the cancer patient: Observations on sensitization by DNCB . Surgery 73:730-735, 1973. 9. Chretien PB, Crowder WL, Gertner HR, et al: Correlation of pre-operative lymphocyte reactivity with the clinical course of cancer patients . Surg Gynecol Obstet 136:380-384, 1973. 10. Twomey PL, Catalona WJ, Chretien PB: Cellular immunity in cured cancer patients . Cancer 33:435-440, 1974.Crossref 11. Eastham RJ, Mason JM, Jennings BR, et al: T-cell rosette test in squamous cell carcinoma of the head and neck . Arch Otolaryngol 102:171-175, 1975.Crossref 12. Olkowski ZL, Wilkins SA: T-lymphocyte levels in the peripheral blood of patients with cancer of the head and neck . Am J Surg 130:440-444, 1975.Crossref 13. Wanebo HJ, Jun MY, Strong EW, et al: T-cell deficiency in patients with squamous cell cancer of the head and neck . Am J Surg 130:445-451, 1975.Crossref 14. Stefano S, Kerman R, Abbate J: Serial studies of immunocompetence in head and neck cancer patients undergoing radiation therapy . Am J Roentgenol Radium Ther Nucl Med 126:880-886, 1976.Crossref 15. Wybran J, Fudenberg HH: Thymusderived rosette-forming cells in various human disease states: Cancer, lymphoma, bacterial and viral infections, and other disease . J Clin Invest 52:1026-1032, 1973.Crossref 16. Niklasson PM, Williams RC Jr: Studies of peripheral blood T- and B-lymphocytes in acute infections . Infect Immun 9:1-7, 1974. 17. Wybran J, Fudenberg HH: Rosette formation: A test for cellular immunity . Trans Assoc Am Physicians 84:239-245, 1971. 18. Donaldson RC: Methotrexate plus bacillus Calmette-Guerin (BCG) and isoniazid in the treatment of cancer of the head and neck . Am J Surg 124:527-534, 1972.Crossref 19. Donaldson RC: Chemoimmunotherapy for cancer of the head and neck . Am J Surg 126:507-512, 1973.Crossref

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Apr 1, 1977

References