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Systemic Sclerosis Associated With Multiple Sclerosis

Systemic Sclerosis Associated With Multiple Sclerosis Abstract To the Editor.— Multiple sclerosis is a chronic demyelinating disease that affects the central nervous system. The characteristic pathologic feature is the breakdown of the myelin sheath, with relative sparing of axons. Recently, an immunologic disorder has been found, and it has been said that an autoimmune basis may be related to the pathogenesis of the disease. In this study, we report a case of systemic sclerosis associated with multiple sclerosis. Report of a Case.— A 42-year-old woman was healthy until 1974, when she developed dysesthesia in the left leg. Paraplegia in both legs and gait disturbance appeared in 1975, and paropsis and dysuria were noted in 1976. Results of a physical examination revealed reduced light reflex of the left eye, decreased sensation below the C8 level, and muscle weakness in her left leg. Hyperactivity of the deep tendon reflexes and Babinski's sign were detected. Multiple sclerosis was diagnosed and References 1. McFarlin DE, McFarland HF. Multiple sclerosis . N Engl J Med. 1982;307:1183-1188, 1246-1251.Crossref 2. Trostle DC, Helfrich D, Medsger TA Jr. Systemic sclerosis (scleroderma) and multiple sclerosis . Arthritis Rheum. 1986;29:124-127.Crossref 3. Reveille JD, Wilson RW, Provost TT, Bias WB, Arnett FC. Primary Sjögren's syndrome and other autoimmune diseases in families: prevalence and immunogenetic studies in six kindreds . Ann Intern Med. 1984;101:748-756.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Systemic Sclerosis Associated With Multiple Sclerosis

Systemic Sclerosis Associated With Multiple Sclerosis

Abstract

Abstract To the Editor.— Multiple sclerosis is a chronic demyelinating disease that affects the central nervous system. The characteristic pathologic feature is the breakdown of the myelin sheath, with relative sparing of axons. Recently, an immunologic disorder has been found, and it has been said that an autoimmune basis may be related to the pathogenesis of the disease. In this study, we report a case of systemic sclerosis associated with multiple sclerosis. Report of a Case.—...
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Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1989.01670200121024
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Multiple sclerosis is a chronic demyelinating disease that affects the central nervous system. The characteristic pathologic feature is the breakdown of the myelin sheath, with relative sparing of axons. Recently, an immunologic disorder has been found, and it has been said that an autoimmune basis may be related to the pathogenesis of the disease. In this study, we report a case of systemic sclerosis associated with multiple sclerosis. Report of a Case.— A 42-year-old woman was healthy until 1974, when she developed dysesthesia in the left leg. Paraplegia in both legs and gait disturbance appeared in 1975, and paropsis and dysuria were noted in 1976. Results of a physical examination revealed reduced light reflex of the left eye, decreased sensation below the C8 level, and muscle weakness in her left leg. Hyperactivity of the deep tendon reflexes and Babinski's sign were detected. Multiple sclerosis was diagnosed and References 1. McFarlin DE, McFarland HF. Multiple sclerosis . N Engl J Med. 1982;307:1183-1188, 1246-1251.Crossref 2. Trostle DC, Helfrich D, Medsger TA Jr. Systemic sclerosis (scleroderma) and multiple sclerosis . Arthritis Rheum. 1986;29:124-127.Crossref 3. Reveille JD, Wilson RW, Provost TT, Bias WB, Arnett FC. Primary Sjögren's syndrome and other autoimmune diseases in families: prevalence and immunogenetic studies in six kindreds . Ann Intern Med. 1984;101:748-756.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1989

References