Abstract • The effect of systemic mannitol administration on retinal adhesive force in the rabbit was investigated in vivo. The retinal adhesive force, 1 hour after intravenous mannitol injection (2.5 g/kg), was 45% greater than that in control eyes. When adhesiveness had been weakened by injecting Ca2+ -free edetic acid (EDTA) solution into the subretinal space, intravenous mannitol still enhanced adhesion. Mannitol administration seems to be effective in enhancing retinal adhesion, even under the conditions where it has been weakened by other mechanisms. References 1. Marmor MF. Retinal detachment from hyperosmotic intravitreal injection . Invest Ophthalmol Vis Sci . 1979;18:1237-1244. 2. Negi A, Marmor MF. Effects of subretinal and systemic osmolality on the rate of subretinal fluid resorption . Invest Ophthalmol Vis Sci . 1984;25:616-620. 3. Yao XY, Moore KT, Marmor MF. Systemic mannitol increases retinal adhesiveness measured in vitro . Arch Ophthalmol . 1991;109:275-277.Crossref 4. Zauberman H, deGuillebon H. Retinal traction in vivo and post mortem . Arch Ophthalmol . 1972;87:549-554.Crossref 5. Kita M, Negi A, Kawano S, Honda Y, Maegawa S. Measurement of retinal adhesive force in the in vivo rabbit eye . Invest Ophthalmol Vis Sci . 1990;31:624-628. 6. Marmor MF, Abdul-Rahim AS, Cohen DS. The effect of metabolic inhibitors on retinal adhesion and subretinal fluid resorption . Invest Ophthalmol Vis Sci . 1980;19:893-903. 7. Wiederhielm CA, Woodbury JW, Kirk S, Rushmer RF. Pulsatile pressure in the microcirculation of the frog's mesentery . Am J Physiol . 1964;207:173-176. 8. Integlitta M, Pawula RF, Tompkins WR. Pressure measurements in the mammalian microvasculature . Microvasc Res . 1970;2:212-220.Crossref 9. Kita M, Marmor MF. Lowering Ca2+ concentration in the subretinal space in vivo loosens retinal adhesion. Invest Ophthalmol Vis Sci. In press. 10. Rapaport SI. Osmotic opening of blood-brain and blood-ocular barriers . Exp Eye Res . 1977;24( (suppl) ):499-509.Crossref 11. Ernest JT, Stern WH, Trimble JL. The effect of mannitol infusion on retinal function and oxygen tension . Invest Ophthalmol Vis Sci . 1977;16:670-673.
Archives of Ophthalmology – American Medical Association
Published: Oct 1, 1991
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