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Systemic Immunomodulatory Treatments for Patients With Atopic Dermatitis

Systemic Immunomodulatory Treatments for Patients With Atopic Dermatitis Key PointsQuestionWhat is the relative effectiveness of systemic treatments for patients with atopic dermatitis? FindingsThis network meta-analysis of 39 randomized clinical trials including 6360 patients found that dupilumab and cyclosporine were similarly effective for adult patients with atopic dermatitis for up to 16 weeks of treatment and were more effective than methotrexate and azathioprine. MeaningCyclosporine and dupilumab may have better short-term effectiveness than methotrexate and azathioprine for patients with atopic dermatitis; this analysis will be updated to add evidence as new medications are approved. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2020 Drucker AM et al. JAMA Dermatology.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/jamadermatol.2020.0796
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionWhat is the relative effectiveness of systemic treatments for patients with atopic dermatitis? FindingsThis network meta-analysis of 39 randomized clinical trials including 6360 patients found that dupilumab and cyclosporine were similarly effective for adult patients with atopic dermatitis for up to 16 weeks of treatment and were more effective than methotrexate and azathioprine. MeaningCyclosporine and dupilumab may have better short-term effectiveness than methotrexate and azathioprine for patients with atopic dermatitis; this analysis will be updated to add evidence as new medications are approved.

Journal

JAMA DermatologyAmerican Medical Association

Published: Jun 22, 2020

References