Opinion EDITORIAL Balancing Benefits With Unknown Harms Adewole S. Adamson, MD, MPP; Kanade Shinkai, MD, PhD UV radiation is the most important known modifiable risk In this issue of JAMA, Matta and the same group of FDA factor for the development of skin cancer including mela- investigators conducted a second open-label, randomized noma. Behavioral measures to reduce this risk factor include clinical trial to determine the systemic absorption and phar- seeking shade, wearing hats and protective clothing, avoid- macokinetics of 6 common chemical sunscreen ingredients ing outdoor activities dur- contained in 4 commercially available formulations (3 sprays ing peak sunlight hours, and and 1 lotion). The current study included 3 of the 4 sun- Related article page 256 regularly using sunscreen. screen filters from the previous study (avobenzone, oxyben- Sunscreen ingredients fall into 2 distinct categories: mineral zone, and octocrylene) and 3 additional UV filters (homo- or chemical. Mineral sunscreens contain physical UV filters, salate, octisalate, and octinoxate). The study followed a such as zinc oxide and titanium dioxide, that offer broad- similar protocol requiring participants to apply sunscreen to spectrum UV coverage by reflecting or refracting UV radia- 75% body surface area once on day 1, followed by
JAMA – American Medical Association
Published: Jan 21, 2020
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