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J. Czaczkes, C. Kleeman, M. Koenig, Ralph Boston (1964)
PHYSIOLOGIC STUDIES OF ANTIDIURETIC HORMONE BY ITS DIRECT MEASUREMENT IN HUMAN PLASMA.The Journal of clinical investigation, 43
A. Spiegelman (1963)
Treatment of diabetes insipidus with synthetic vasopressin.JAMA, 184
THE LONG-TERM treatment of vasopressinsensitive diabetes insipidus remains a complex and challenging problem. Vasopressin is available for therapy as an oil-repository material, vasopressin tannate injection (Pitressin Tannate in oil), in aqueous solution, vasopressin injection (Pitressin), and in powder form administered by nasal insufflation, posterior pituitary powder. These forms have certain drawbacks and more convenient therapeutic materials are desirable. Recently, the use of synthetic lysine vasopressin, lysyl-8-vasopressin, as a nasal spray has been studied.1-3 We wish to report our experience to date with this material in 19 patients with vasopressinsensitive diabetes insipidus. Antidiuretic hormone (ADH) levels and disappearance curves in blood have been studied in three patients4; clinical response to the medication is reported here. Methods Lysyl-8-vasopressin spray was provided in 5 ml (50 IU per milliliter) squeeze bottle containers. Two lines of investigation were followed. In the first, three patients (cases 3, 10, and 11) were studied in
JAMA – American Medical Association
Published: Dec 21, 1964
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