Opinion EDITORIAL Symptomatic and Asymptomatic Viral Shedding in Pediatric Patients Infected With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Under the Surface Roberta L. DeBiasi, MD, MS; Meghan Delaney, DO, MPH Since the global emergence and spread of severe acute respi- scrutiny by nature of being identified as a known contact. Pre- ratory syndrome coronavirus 2 (SARS-CoV-2), initial atten- symptomatic children remained symptom free for a median tion appropriately focused on severely affected adults, who rep- (range) of 2.5 (1-25) days before exhibiting any symptoms, de- resent the highest proportion of symptomatic infections. spite detectable virus. Only a minority of children (6 [7%]) were However, as the pandemic identified as infected by testing performed concurrent with on- has evolved, a significant ef- set of their symptoms. This highlights the concept that in- Related article page 73 fect on children has also be- fected children may be more likely to go unnoticed either with come evident. Data from multiple affected countries have cor- or without symptoms and continue on with their usual activi- roborated that children are clearly susceptible to infection and ties, which may contribute to viral circulation within their may develop severe primary and unique secondary inflam- community.
JAMA Pediatrics – American Medical Association
Published: Jan 28, 2021
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