Abstract THERE are certain diseases in all fields of medicine whose essential data have come to be more or less taken for granted. Sympathetic ophthalmia is one of these. Its existence, as Woods1 pointed out in an excellent review of the whole subject, has been realized for almost a thousand years. Its clinical aspects were very well described more than 100 years ago. The pathologic changes in the exciting eye were set forth in considerable detail almost 50 years ago. The potentially devastating character of the disease is thoroughly appreciated by any ophthalmologist who has ever encountered it in his practice. No really satisfactory treatment for it has ever been devised. A recent experience of our own, in which the histologic picture was at complete variance with the classic clinical picture of sympathetic ophthalmia which the patient presented, has made us wonder whether it would not be well to examine References 1. Woods, A. C.: Sympathetic Ophthalmia , Am. J. Ophth. 19:9-16 ( (Jan.) ) 2. 100-109 (Feb.) 1936. 3. Fuchs, E.: Über sympathisierende Entzündung (nebst Bermerkungen über seröse traumatische Iritis) , von Graefes Arch. Ophth. 61:365-456, 1905.Crossref 4. Redslob, E.: Considerations anciennes et nouvelles sur la pathologie et la pathogénie de l'ophtalmie sympathique , Ophthalmologica 118:483-495 ( (Oct.-Nov.) ) 1949.Crossref 5. Samuels, B.: Significance of Specific Infiltration at the Site of Injury in Sympathetic Ophthalmia , Arch. Ophth. 9:540-559 ( (April) ) 1933Crossref 6. Sympathetic Scleritis , Samuels Arch. Ophth. 10:185-197 ( (Aug.) ) 1933.Crossref 7. Friedenwald, J. S.: Notes on the Allergy Theory of Sympathetic Ophthalmia , Am. J. Ophth. 17:1008-1018 ( (Nov.) ) 1934. 8. de Veer, J. A.: Endophthalmitis Phacoanaphylactica and Its Relation to Sympathetic Ophthalmia , Arch. Ophth. 23:237-252 ( (Feb.) ) 1940.Crossref 9. Schlaegel, T. F., Jr., and Davis, J. B.: The Reaction of the Rabbit Eye to Normal Horse Serum: Sensitization by Intradermal Injection , Am. J. Ophth. 26:785-798 ( (Aug.) ) 1943. 10. Collins, R. C.: Experimental Studies on Sympathetic Ophthalmia , Am. J. Ophth. 32:1687-1699 ( (Dec.) ) 1949. 11. Loewenstein, A.: The Sympathizing Eye , Tr. Ophth. Soc. United Kingdom 65:219-231, 1945. 12. Greeves, R. A.: A Contribution to the Microscopical Anatomy of the Sympathizing Eye , Brit. J. Ophth. 32:545-550 ( (Sept.) ) 1948.Crossref 13. Wood, D. J.: Two Cases of Sympathetic Ophthalmitis , Brit. J. Ophth. 14:291-297 ( (June) ) 1930.Crossref 14. Courtney, R. H.: Endophthalmitis with Secondary Glaucoma Accompanying Absorption of the Crystalline Lens , Tr. Am. Ophth. Soc. 40:355-369, 1942. 15. Verhoeff, F. H., and Lemoine, A. N.: Endophthalmitis Phacoanaphylactica , Am. J. Ophth. 5:737 ( (Sept.) ) 1922. 16. Walsh, F. B.: Clinical Neuro-Ophthalmology , Baltimore, Williams & Wilkins Company, 1947. 17. Rohmer, F., and Lobstein, A.: Bearing of Electro-Encephalography on Some Ocular Diseases, Especially Sympathetic Ophthalmia , Rev. neurol. 82:571-573, 1950 18. abstracted in Ophth. Lit. 4:607 ( (March) ) 1951. 19. Cowper, A. R.: Harada's Disease ind Vogt-Koyanagi Syndrome : Uveoencephalitis. A. M. A. Arch. Ophth. 45:367-376 ( (April) ) 1951.Crossref 20. (a) Woods, A. C.: Clinical and Experimental Observation on the Use of ACTH and Cortisone in Ocular Inflammatory Disease , Am. J. Ophth. 33:1325-1349 ( (Sept.) ) 1950 21. (b) Present Status of ACTH and Cortisone in Ophthalmology (Gifford Memorial Lecture), to be published. 22. (c) Woods, A. C., and Woods, R. M.: Action of ACTH and Cortisone on Experimental Ocular Inflammation , Bull. Johns Hopkins Hosp. 87:482-504 ( (Nov.) ) 1950. 23. Hench, P. S.: Introduction: Cortisone and ACTH in Clinical Medicine , Proc. Staff Meet., Mayo Clin. 25:474-476 ( (Aug. 16) ) 1950. 24. The following ophthalmologists furnished the data upon which this study is based: Drs. S. D. Aiken; F. H. Adler; B. Y. Alvis; C. Berens; M. L. Berliner; F. P. Calhoun; A. Callahan; R. Castroviejo: F. C. Cordes; T. O Costen; R. K. Daily; A. G. DeVoe; J. H. Dunnington; E. B. Dunphy; A. J. Elliot; H. Gifford; J. S. Friedenwald; E. L. Goar; T. Gundersen; P. Heath; M. J. Hogan; F. Hollabaugh; W. F. Hughes, Jr.; C. E. Iliff: C. D. F. Jensen; L. V. Johnson; H. M. Katzin; P. C. Kronfeld; S. R. Irvine; J. Laval; A. N. Lemoine; I. H. Leopold; D. J. Lyle; R. J. Masters; P. R. McDonald; J. S. McGavic; J. W. McKinney; J. M. McLean; S. D. McPherson Jr.; F. H. Newton; W. C. Owens; R. T. Paton; B. F. Payne; D. K. Pischel; M. H. Post Jr.; A. B. Reese; C. W. Rucker; B. Samuels; H. G. Scheie; C. P. Sullivan; T. E. Sanders; M. Thomas; H. E. Thorpe; P. Thygeson; S. M. Truhlsen; D. Vail; L. von Sallmann; K. C. Swan, and A. C. Woods. 25. (a) Woods.16a 26. (b) Fitzgerald, J. R.; Bellows, J. G.; Donegan, J. M.; Gamble, R. C.; Krause, A. C.; Mann, W. A.; Pearlman, M. D., and Zekman, T. N.: Early Clinical Results of ACTH and Cortisone Treatment of Ocular Diseases , A. M. A. Arch. Ophth. 45:320-333 ( (March) ) 1951.Crossref 27. (c) Leopold, I. H.: Clinical Trial with Chloramphenicol in Ocular Infections , A. M. A. Arch. Ophth. 45:33-52 ( (Jan.) ) 1951.Crossref 28. (d) Raiford, M.: Use of Cortisone and ACTH in Ophthalmology , Guildcraft 25:15-19, 22-24 ( (April) ) 1951. 29. Leopold, I. H.: Clinical Trial with Chloramphenicol in Ocular Infections , A. M. A. Arch. Ophth. 45:44-52 ( (Jan.) ) 1951.Crossref 30. Selye, H.: General Adaptation Syndrome and the Diseases of Adaptation , J. Clin. Endocrinol. 6:117-230 ( (Feb.) ) 1946.Crossref 31. Arendshorst, W., and Falls, H. F.: Role of the Adrenal Cortex in Treatment of Ocular Diseases with Pyrogenic Substances , Arch. Ophth. 44:635-642 ( (Nov.) ) 1950.Crossref
A.M.A. Archives of Ophthalmology – American Medical Association
Published: Apr 1, 1952
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