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the of excretion of sodium salt 15 of mean to given per kilogram body mg. drug urinary prior restriction in the al- The dose was later raised to 25 was two per weight. mg. comparable groups, marked individual in 7 of 10 were variations were seen. these; 5) given though kilogram (group The After withdrawal sodium sodium 40 in three divided doses. of the amount of per mg. kilogram 10 in urine a in usual of but the excreted the showed fall both was period therapy days drug rapid was no was discontinued earlier if the increased and there difference dysentery groups appreciable worse. in or the condition became between them. On with sodium, however, general loading severity the showed In 12 in 4 blood and a to mucus hypertensive tendency patients patients group sodium and than did the normo- from stools in four and in 10 more water reject disappeared days tensive the the stools became formed on the seventh The The levels of in subjects. electrolytes day. of the from the stools serum showed no on with- appreciable disappearance trophozoites change on on third in drawal an the 12 or occurred, average, day loading. discontinued In four
JAMA – American Medical Association
Published: Feb 28, 1959
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