Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Survival After High Blood Alcohol Levels: Association With First-Order Elimination Kinetics

Survival After High Blood Alcohol Levels: Association With First-Order Elimination Kinetics Abstract • A patient survived acute alcohol intoxication with an unprecedented blood alcohol level of 1,500 mg/dL. Treatment included peritoneal dialysis and intravenously administered fructose. Alcohol elimination followed first-order kinetics, in which the elimination rate is proportional to concentration, rather than zero order in which the metabolic rate is independent of concentration. The report provides further evidence for first-order elimination kinetics with high blood alcohol levels and for an adaptive increase in alcohol metabolism with long-term alcohol consumption. (Arch Intern Med 1984;144:641-642) References 1. Wallgren H, Barry H: Actions of Alcohol . Amsterdam, Elsevier Publishing Co, 1970, pp 55-75. 2. Hammond KB, Rumack BH, Rodgerson DO: Blood ethanol: A report of unusually high levels in a living patient. JAMA 1973;226:63-64.Crossref 3. Lindblad B, Olsson R: Unusually high levels of blood alcohol? JAMA 1976;236:1600-1602.Crossref 4. Plapp B: Rate limiting steps in ethanol metabolism and approaches to changing their rate biochemically. Adv Exp Med Biol 1975;56:77-109. 5. Feinman L, Baraona E, Matsuzaki S, et al: Concentration dependence of ethanol metabolism in vivo in rats and man: Alcoholism. Clin Exp Res 1978;2:381-385.Crossref 6. Misra PS, Lefevre A, Ishii H, et al: Increase of ethanol, meprobamate and pentobarbital metabolism after chronic ethanol administration in man and in rats. Am J Med 1971;51:346-351.Crossref 7. Salaspuro MP, Lieber CS: Non-uniformity of blood ethanol elimination: Its exaggeration after chronic consumption. Ann Clin Res 1978;10: 294-297. 8. Lieber CS, De Carli LM: The role of the hepatic microsomal ethanol oxidizing system (MEOS) for ethanol metabolism in vivo. J Pharmacol Exp Ther 1972;181:279-287. 9. Lieber CS, De Carli LM: Ethanol oxidation by hepatic microsomes: Adaptive increases after ethanol feeding. Science 1968;162:917-918.Crossref 10. Li TK, Bosron WF, Dafeldecker WP, et al: Isolation of Pi-alcohol dehydrogenase of human liver: Is it a determinant of alcoholism? Proc Natl Acad Sci USA 1977;74:4378-4381.Crossref 11. Gordon E, Pikkarainen P, Matsuzaki S, et al: The effect of chronic ethanol consumption on pathways of ethanol metabolism , in Thurman RG (ed): Alcohol and Aldehyde Metabolizing Systems . New York, Plenum Publishing Corp, 1980, vol 4, 1980, pp 475-480. 12. Brown SS, Forrest JAH, Roscoe P: A controlled trial of fructose in the treatment of acute alcoholic intoxication. Lancet 1972;2:898-899.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Survival After High Blood Alcohol Levels: Association With First-Order Elimination Kinetics

Loading next page...
 
/lp/american-medical-association/survival-after-high-blood-alcohol-levels-association-with-first-order-knE4SFwWyZ
Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1984.00350150255052
Publisher site
See Article on Publisher Site

Abstract

Abstract • A patient survived acute alcohol intoxication with an unprecedented blood alcohol level of 1,500 mg/dL. Treatment included peritoneal dialysis and intravenously administered fructose. Alcohol elimination followed first-order kinetics, in which the elimination rate is proportional to concentration, rather than zero order in which the metabolic rate is independent of concentration. The report provides further evidence for first-order elimination kinetics with high blood alcohol levels and for an adaptive increase in alcohol metabolism with long-term alcohol consumption. (Arch Intern Med 1984;144:641-642) References 1. Wallgren H, Barry H: Actions of Alcohol . Amsterdam, Elsevier Publishing Co, 1970, pp 55-75. 2. Hammond KB, Rumack BH, Rodgerson DO: Blood ethanol: A report of unusually high levels in a living patient. JAMA 1973;226:63-64.Crossref 3. Lindblad B, Olsson R: Unusually high levels of blood alcohol? JAMA 1976;236:1600-1602.Crossref 4. Plapp B: Rate limiting steps in ethanol metabolism and approaches to changing their rate biochemically. Adv Exp Med Biol 1975;56:77-109. 5. Feinman L, Baraona E, Matsuzaki S, et al: Concentration dependence of ethanol metabolism in vivo in rats and man: Alcoholism. Clin Exp Res 1978;2:381-385.Crossref 6. Misra PS, Lefevre A, Ishii H, et al: Increase of ethanol, meprobamate and pentobarbital metabolism after chronic ethanol administration in man and in rats. Am J Med 1971;51:346-351.Crossref 7. Salaspuro MP, Lieber CS: Non-uniformity of blood ethanol elimination: Its exaggeration after chronic consumption. Ann Clin Res 1978;10: 294-297. 8. Lieber CS, De Carli LM: The role of the hepatic microsomal ethanol oxidizing system (MEOS) for ethanol metabolism in vivo. J Pharmacol Exp Ther 1972;181:279-287. 9. Lieber CS, De Carli LM: Ethanol oxidation by hepatic microsomes: Adaptive increases after ethanol feeding. Science 1968;162:917-918.Crossref 10. Li TK, Bosron WF, Dafeldecker WP, et al: Isolation of Pi-alcohol dehydrogenase of human liver: Is it a determinant of alcoholism? Proc Natl Acad Sci USA 1977;74:4378-4381.Crossref 11. Gordon E, Pikkarainen P, Matsuzaki S, et al: The effect of chronic ethanol consumption on pathways of ethanol metabolism , in Thurman RG (ed): Alcohol and Aldehyde Metabolizing Systems . New York, Plenum Publishing Corp, 1980, vol 4, 1980, pp 475-480. 12. Brown SS, Forrest JAH, Roscoe P: A controlled trial of fructose in the treatment of acute alcoholic intoxication. Lancet 1972;2:898-899.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Mar 1, 1984

References