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Surgical Research in the Communication Zone: II. Enzyme Fluctuations in Wounded Combat Soldiers During the Convalescent Period

Surgical Research in the Communication Zone: II. Enzyme Fluctuations in Wounded Combat Soldiers... Abstract The distribution of enzymes in tissue and cell structures is important in the clinical application of serum enzyme determinations. For example, sorbitol dehydrogenase (SDH) and fructose -1, 6-diphosphate aldolase occur only in liver, while creatine phosphokinase (CPK) appears in high concentration in striated muscle. Since almost one third of the body weight consists of the skeletal musculature, even small subclinical injuries to this large tissue mass will lead to changes in the serum enzyme pattern.1 The purpose of this study was to evaluate fluctuations in CPK, lactic dehydrogenase (LDH), and serum glutamic oxaloacetic transaminase (SGOT) enzymes in wounded patients evacuated from the Republic of Vietnam to Japan in order to evaluate the efficacy of enzyme values as a means of determining the ideal time for delayed primary closure. Materials and Methods A total of 205 patients were randomly selected for CPK determination from the general surgery, orthopedic and septic References 1. Schmidt, E., and Schmidt, F.W.: Guide to Practical Enzyme Diagnosis , Mannheim, Germany: CF. Buehringer and Suehne G.M.B.H.; 1965. 2. Creatinine Phosphokinase in Serum or Other Fluid , Technical bulletin 520, No. 80-F, St. Louis, Sigma Chemical Company, (June) 1967. 3. Goto, I.; Peters, H.A.; and Reese, H.H.: Creatinine Phosphokinase in Neuromuscular Disease , Arch Neurol 16:529-535 ( (May) ) 1967.Crossref 4. Eshchar, J., and Zimmerman, H.J.: Creatinine Phosphokinase in Disease , Amer J Med Sci 253:272-282 ( (March) ) 1967.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Surgical Research in the Communication Zone: II. Enzyme Fluctuations in Wounded Combat Soldiers During the Convalescent Period

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Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1969.01340160117028
Publisher site
See Article on Publisher Site

Abstract

Abstract The distribution of enzymes in tissue and cell structures is important in the clinical application of serum enzyme determinations. For example, sorbitol dehydrogenase (SDH) and fructose -1, 6-diphosphate aldolase occur only in liver, while creatine phosphokinase (CPK) appears in high concentration in striated muscle. Since almost one third of the body weight consists of the skeletal musculature, even small subclinical injuries to this large tissue mass will lead to changes in the serum enzyme pattern.1 The purpose of this study was to evaluate fluctuations in CPK, lactic dehydrogenase (LDH), and serum glutamic oxaloacetic transaminase (SGOT) enzymes in wounded patients evacuated from the Republic of Vietnam to Japan in order to evaluate the efficacy of enzyme values as a means of determining the ideal time for delayed primary closure. Materials and Methods A total of 205 patients were randomly selected for CPK determination from the general surgery, orthopedic and septic References 1. Schmidt, E., and Schmidt, F.W.: Guide to Practical Enzyme Diagnosis , Mannheim, Germany: CF. Buehringer and Suehne G.M.B.H.; 1965. 2. Creatinine Phosphokinase in Serum or Other Fluid , Technical bulletin 520, No. 80-F, St. Louis, Sigma Chemical Company, (June) 1967. 3. Goto, I.; Peters, H.A.; and Reese, H.H.: Creatinine Phosphokinase in Neuromuscular Disease , Arch Neurol 16:529-535 ( (May) ) 1967.Crossref 4. Eshchar, J., and Zimmerman, H.J.: Creatinine Phosphokinase in Disease , Amer J Med Sci 253:272-282 ( (March) ) 1967.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Oct 1, 1969

References