RESIDENT’S FORUM SECTION EDITORS: RICHARD D. SCHULICK, MD, MBA; PAMELA A. LIPSETT, MD, MPHE Surgical Management of the Succinate Dehydrogenase–Associated Familial Paraganglioma Syndromes Andrei Cocieru, MD; Pierre F. Saldinger, MD aragangliomas are rare neuroendocrine tumors arising from the neural crest cells in the extra-adrenal location. Paragangliomas can be sporadic or associated with a range of endocrine and genetic syndromes in 25% to 30% of all cases. Specifically, succinate de- P hydrogenase gene mutations are involved in the development of paraganglioma syn- dromes type 1 through type 4. In this article, we will describe 2 cases of succinate dehydrogenase– associated familial paraganglioma syndrome and provide a review of the existing literature on the condition’s etiologic factors, diagnosis, and management. Arch Surg. 2012;147(1):89-91 Paragangliomas (PGLs) are rare neuroen- a well-encapsulated tumor with argyro- docrine tumors arising from the neural philic tumor cells positive on immuno- crest cells in the extra-adrenal location. chemical analysis for chromogranin and Paragangliomas can be sporadic or asso- negative for S-100 protein, consistent ciated with the other hereditary tumor with the diagnosis of PGL. The patient syndromes. had complete resolution of the arterial In this article, we report on 2 cases of hypertension with normalization of uri-
JAMA Surgery – American Medical Association
Published: Jan 1, 2012
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera