Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Supralethal Total-Body X-Irradiation: Effects on the Spinal Cord of Parabiont Rats

Supralethal Total-Body X-Irradiation: Effects on the Spinal Cord of Parabiont Rats Abstract ONLY a limited amount of data exist on the effect of radiation on neurons. The central nervous system (CNS) is generally fairly resistant to radiation therapy. This is indeed fortunate as a fair number of lesions in man best treated by radiation occur in close proximity to the brain and spinal cord. Histopathological studies on changes resulting from radiation of the CNS have usually been limited to investigation of effects of localized x-irradiation. Inferior performance in running time was found in Sprague-Dawley rats irradiated with 2,500 rads or 5,000 rads to the forebrain. On histologic examination of the animals, necrotic foci were found in the brain, the neuroglial cells were somewhat hypertrophied, and there was moderate radiation change in blood vessels.1 Vogel2 found minimal damage to neurons in monkeys receiving over 2,500 roentgens (R) with a sharp increase in injury from 5,000 R. The granular cells were References 1. Ingersoll, E.H.; Carsten, A.L.; and Brownson, R.H.: Behavioral and Structural Changes Following X-Irradiation of the Forebrain in the Rat , Proc Soc Exp Biol 125:382-385, 1967.Crossref 2. Vogel, F.S.: " Effects of High-Dose Gamma Radiation on the Brain and on Individual Neurons ," in Haley, T.J., and Snider, R.S. (eds.): Response of the Nervous System to Ionizing Radiation , New York: Academic Press, Inc., 1962, pp 249-260. 3. Maxwell, D.S., and Kruger, L.: In Haley, T.J., and Snider, R.S. (eds.): Response of the Nervous System to Ionizing Radiation , Second International Symposium, University of California, Los Angeles, Boston: Little, Brown and Co., 1964, pp 54-83. 4. Rose, J.E., et al: Effects of Heavy, Ionizing, Monoenergetic Particles on the Cerebral Cortex: II. Histological Appearance of Laminar Lesions and Growth of Nerve Fibers After Laminar Destruction , J Comp Neurol 115:243-255, 1960.Crossref 5. Gzelishvili, M.S.: Brain Injury at Various Periods After Radiotherapy, Izv Akad Nauk Azerbaidzh SSR , Ser Biol Nauk , no (6) , 125-131, 1966. 6. Krayevskii, N.A.: Studies in the Pathology of Radiation Disease , A. Lieberman (trans.), London: Pergamon Press, 1965, pp 118-119. 7. Hu, J.: Effects of a Single Dose of Whole-Body Irradiation on the Synapses of the Spinal Cord of Mouse , Chieh Pou Hsueh Pao 9:30-38, 1966 (Nuclear Science Abstracts 21:56, 1967, Abst no 421). 8. Davidoff, L.M., et al: The Effect of Radiation Applied Directly to the Brain and Spinal Cord: I. Experimental Investigations on Macacus rhesus Monkeys , Radiology 31:451-463, 1938.Crossref 9. McLaurin, R.L., et al: The Effects of Gamma and Roentgen Radiation on the Intact Spinal Cord of the Monkey: An Experimental Study , Amer J Roentgen 73:827-835, 1955. 10. Altman, J.: In Haley, T.J., and Snider, R.S. (eds.): Response of the Nervous System to Ionizing Radiation , Second International Symposium, University of California, Los Angeles, Boston: Little, Brown & Co., 1964, pp 336-359. 11. Lyman, R.S.; Kupalov, P.S.; and Scholz, W.: Effect of Roentgen Rays on the Central Nervous System , Arch Neurol Psychiat 29:56-87, 1933.Crossref 12. Scholz, W.; Ducho, E.G.; and Breit, A.: Experimentalle Röntgenspätschaden am Rückenmark des erwachsenen Kaninchens , Psychiat Neurol Jap 61:417-442, 1959. 13. Scholz, W.; Schlote, W.; and Hirschberger, W.: " Morphological Effect of Repeated Low Dosage and Single High Dosage Application of X-Irradiation to the Central Nervous System ," in Haley, T.J., and Snider, R.S. (eds.): Response of the Nervous System to Ionizing Radiation , Proceedings of an International Symposium, Northwestern University Medical School, Chicago, Sept 7-9, 1960, New York: Academic Press, Inc., 1962, pp 211-232. 14. Innes, J.R., and Carsten, A.: " A Demyelinating or Malacic Myelopathy and Myodegeneration— Delayed Effect of Localized X-Irradiation in Experimental Rats and Monkeys ," in Haley, T.J., and Snider, R.S. (eds.): Response of the Nervous System to Ionizing Radiation , Proceedings of an International Symposium, Northwestern University Medical School, Chicago, Sept 7-9, 1960, New York: Academic Press, Inc., 1962, pp 233-247. 15. Zeman, W.; Carsten, A.; and Biondo, S.: " Cytochemistry of Delayed Radionecrosis of the Murine Spinal Cord ," in Haley, T.J., and Snider, R.S. (eds.): Response of the Nervous System to Ionizing Radiation , Second International Symposium, University of California, Los Angeles, Boston: Little, Brown & Co., 1964, pp 105-126. 16. Zeman, W.: Zur Pathogenese der Strahlenspätschädigung des Rückenmarks , Strahlentherapie (Sonderb) 62:68-76, 1966. 17. Carsten, A., and Zeman, W.: The Control of Variables in Radiopathological Studies on Mammalian Nervous Tissue , Int J Radiat Biol 10:65-74, 1966.Crossref 18. Breit, A.: Die Strahlentoleranz Des Rückenmarks , Strahlentherapie (Sonderb) 62:77-83, 1966. 19. Boden, G.: Radiation Myelitis of the Cervical Spinal Cord , Brit J Radiol 21:464-469, 1948.Crossref 20. Dynes, J.B., and Smedal, M.I.: Radiation Myelitis , Amer J Roentgen 83:78-87, 1960. 21. Held, F.; Panther, W.; and Schroter, P.: Strahlenschäden am Halsmark nach therapeutischer Malignombestrahlung , Radiobiol Radiother 5:419-428, 1964. 22. Zvara, J.; Pribys, R.; and Hradil, I.: Changes in the Region of Ventral Spinal Columns in Rats Irradiated by a Lethal Dose of X-Rays , Morfologie 12:40-49, 1963. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Supralethal Total-Body X-Irradiation: Effects on the Spinal Cord of Parabiont Rats

Loading next page...
 
/lp/american-medical-association/supralethal-total-body-x-irradiation-effects-on-the-spinal-cord-of-f03rlYle6v
Publisher
American Medical Association
Copyright
Copyright © 1968 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1968.00470360125013
Publisher site
See Article on Publisher Site

Abstract

Abstract ONLY a limited amount of data exist on the effect of radiation on neurons. The central nervous system (CNS) is generally fairly resistant to radiation therapy. This is indeed fortunate as a fair number of lesions in man best treated by radiation occur in close proximity to the brain and spinal cord. Histopathological studies on changes resulting from radiation of the CNS have usually been limited to investigation of effects of localized x-irradiation. Inferior performance in running time was found in Sprague-Dawley rats irradiated with 2,500 rads or 5,000 rads to the forebrain. On histologic examination of the animals, necrotic foci were found in the brain, the neuroglial cells were somewhat hypertrophied, and there was moderate radiation change in blood vessels.1 Vogel2 found minimal damage to neurons in monkeys receiving over 2,500 roentgens (R) with a sharp increase in injury from 5,000 R. The granular cells were References 1. Ingersoll, E.H.; Carsten, A.L.; and Brownson, R.H.: Behavioral and Structural Changes Following X-Irradiation of the Forebrain in the Rat , Proc Soc Exp Biol 125:382-385, 1967.Crossref 2. Vogel, F.S.: " Effects of High-Dose Gamma Radiation on the Brain and on Individual Neurons ," in Haley, T.J., and Snider, R.S. (eds.): Response of the Nervous System to Ionizing Radiation , New York: Academic Press, Inc., 1962, pp 249-260. 3. Maxwell, D.S., and Kruger, L.: In Haley, T.J., and Snider, R.S. (eds.): Response of the Nervous System to Ionizing Radiation , Second International Symposium, University of California, Los Angeles, Boston: Little, Brown and Co., 1964, pp 54-83. 4. Rose, J.E., et al: Effects of Heavy, Ionizing, Monoenergetic Particles on the Cerebral Cortex: II. Histological Appearance of Laminar Lesions and Growth of Nerve Fibers After Laminar Destruction , J Comp Neurol 115:243-255, 1960.Crossref 5. Gzelishvili, M.S.: Brain Injury at Various Periods After Radiotherapy, Izv Akad Nauk Azerbaidzh SSR , Ser Biol Nauk , no (6) , 125-131, 1966. 6. Krayevskii, N.A.: Studies in the Pathology of Radiation Disease , A. Lieberman (trans.), London: Pergamon Press, 1965, pp 118-119. 7. Hu, J.: Effects of a Single Dose of Whole-Body Irradiation on the Synapses of the Spinal Cord of Mouse , Chieh Pou Hsueh Pao 9:30-38, 1966 (Nuclear Science Abstracts 21:56, 1967, Abst no 421). 8. Davidoff, L.M., et al: The Effect of Radiation Applied Directly to the Brain and Spinal Cord: I. Experimental Investigations on Macacus rhesus Monkeys , Radiology 31:451-463, 1938.Crossref 9. McLaurin, R.L., et al: The Effects of Gamma and Roentgen Radiation on the Intact Spinal Cord of the Monkey: An Experimental Study , Amer J Roentgen 73:827-835, 1955. 10. Altman, J.: In Haley, T.J., and Snider, R.S. (eds.): Response of the Nervous System to Ionizing Radiation , Second International Symposium, University of California, Los Angeles, Boston: Little, Brown & Co., 1964, pp 336-359. 11. Lyman, R.S.; Kupalov, P.S.; and Scholz, W.: Effect of Roentgen Rays on the Central Nervous System , Arch Neurol Psychiat 29:56-87, 1933.Crossref 12. Scholz, W.; Ducho, E.G.; and Breit, A.: Experimentalle Röntgenspätschaden am Rückenmark des erwachsenen Kaninchens , Psychiat Neurol Jap 61:417-442, 1959. 13. Scholz, W.; Schlote, W.; and Hirschberger, W.: " Morphological Effect of Repeated Low Dosage and Single High Dosage Application of X-Irradiation to the Central Nervous System ," in Haley, T.J., and Snider, R.S. (eds.): Response of the Nervous System to Ionizing Radiation , Proceedings of an International Symposium, Northwestern University Medical School, Chicago, Sept 7-9, 1960, New York: Academic Press, Inc., 1962, pp 211-232. 14. Innes, J.R., and Carsten, A.: " A Demyelinating or Malacic Myelopathy and Myodegeneration— Delayed Effect of Localized X-Irradiation in Experimental Rats and Monkeys ," in Haley, T.J., and Snider, R.S. (eds.): Response of the Nervous System to Ionizing Radiation , Proceedings of an International Symposium, Northwestern University Medical School, Chicago, Sept 7-9, 1960, New York: Academic Press, Inc., 1962, pp 233-247. 15. Zeman, W.; Carsten, A.; and Biondo, S.: " Cytochemistry of Delayed Radionecrosis of the Murine Spinal Cord ," in Haley, T.J., and Snider, R.S. (eds.): Response of the Nervous System to Ionizing Radiation , Second International Symposium, University of California, Los Angeles, Boston: Little, Brown & Co., 1964, pp 105-126. 16. Zeman, W.: Zur Pathogenese der Strahlenspätschädigung des Rückenmarks , Strahlentherapie (Sonderb) 62:68-76, 1966. 17. Carsten, A., and Zeman, W.: The Control of Variables in Radiopathological Studies on Mammalian Nervous Tissue , Int J Radiat Biol 10:65-74, 1966.Crossref 18. Breit, A.: Die Strahlentoleranz Des Rückenmarks , Strahlentherapie (Sonderb) 62:77-83, 1966. 19. Boden, G.: Radiation Myelitis of the Cervical Spinal Cord , Brit J Radiol 21:464-469, 1948.Crossref 20. Dynes, J.B., and Smedal, M.I.: Radiation Myelitis , Amer J Roentgen 83:78-87, 1960. 21. Held, F.; Panther, W.; and Schroter, P.: Strahlenschäden am Halsmark nach therapeutischer Malignombestrahlung , Radiobiol Radiother 5:419-428, 1964. 22. Zvara, J.; Pribys, R.; and Hradil, I.: Changes in the Region of Ventral Spinal Columns in Rats Irradiated by a Lethal Dose of X-Rays , Morfologie 12:40-49, 1963.

Journal

Archives of NeurologyAmerican Medical Association

Published: Jun 1, 1968

References