Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Suppression of Immune-Mediated Otitis Media by T-Suppressor Cells

Suppression of Immune-Mediated Otitis Media by T-Suppressor Cells Abstract • Effects of mucosa-derived T-suppressor cells on induction of IgG-mediated otitis media with effusion (OME) were investigated in mice, since antigenantibody reactions in the tympanic cavity are pathogenic mechanisms of OME. Splenic T-suppressor cells from strain C3H/HeN female mice, to which ovalbumin (OVA) had been orally administered, were transferred intravenously to syngeneic mice. The mice receiving the T-suppressor cells were immunized with OVA intraperitoneally and then injected with OVA into the tympanic cavity. Nine of ten control mice, to which splenic T cells from saline-fed mice were administered, developed OME, while OME was seen in only one of ten mice receiving splenic T cells from OVA-fed mice. The results show that IgG-mediated OME can be suppressed to a certain extent by the induction of antigen-specific, mucosa-derived, T-suppressor cells. (Arch Otolaryngol Head Neck Surg 1988;114:878-882) References 1. Ryan AF, Catanzaro A, Wasserman SI, et al: Secondary immune response in the middle ear: Immunological, morphological, and physiological observations . Ann Otol Rhinol Laryngol 1986;95:242-249. 2. Mogi G: Experimental OME with emphasis on mucosal immunity , in Feldman JE, Huizing EH, Lim DJ, et al (eds): Immunobiology, Histopathology, Tumor Immunology in Otorhinolaryngology . Amsterdam, Kugler Publications, 1987, pp 253-263. 3. Mravec J, Lewis DM, Lim DJ: Experimental otitis media with effusion: An immune complex-mediated response . Otolaryngology 1978;86:258-268. 4. Mogi G, Honjo S, Yoshida T, et al: Secretory immunoglobulin A (SIgA) in middle ear effusions: A further report . Ann Otol Rhinol Laryngol 1974;83:92-101. 5. Bernstein JM, Tomasi TB Jr, Ogra PL: The immunochemistry of middle ear effusions . Arch Otolaryngol Head Neck Surg 1974;99:320-326.Crossref 6. Richman LK, Graeff AS, Yarchean R, et al: Simultaneous induction of antigen-specific IgA helper T cells and IgG suppressor T cells in murine Peyer's patches after protein feeding . J Immunol 1981;126:2079-2083. 7. Challacombe SJ, Tomasi TB Jr: Systemic tolerance and secretory immunity after oral immunization . J Exp Med 1980;152:1459-1472.Crossref 8. Tomasi TB: Oral tolerance . Transplantation 1980;29:353-356.Crossref 9. Craig SW, Cebra JJ: Peyer's patches: An enriched source of precursors for IgA-producing immunocytes in the rabbit . J Exp Med 1974; 134:188-200.Crossref 10. Julius MH, Simpson E, Herzenberg LA: A rapid method for the isolation of functional thymus-derived murine lymphocytes . Eur J Immunol 1973;3:645-649.Crossref 11. Cunningham AJ, Szenberg A: Further improvements in the plaque technique for detecting single antibody-forming cells . Immunology 1968;14:599-600. 12. Suzuki M, Kawauchi M, Ueyama S, et al: Immune-mediated otitis media with effusion , in Lim DJ, Bluestone CD, Klein JO, et al (eds): Recent Advances in Otitis Media . Philadelphia, BC Decker Inc, in press. 13. Wells HG: Studies on the chemistry of anaphylaxis: III. Experiments with isolated proteins, especially those of the hen's egg . J Infect Dis 1911;9:147-171.Crossref 14. Chase MW: Inhibition of experimental drug allergy by prior feeding of the sensitizing agent . Proc Soc Exp Biol Med 1946;61:257-261.Crossref 15. Mattingly JA, Waksman BH: Immunologic suppression after oral administration of antigen: I. Specific suppressor cells formed in rat Peyer's patches after oral administration of sheep erythrocytes and their systemic migration . J Immunol 1978;121:1878-1883. 16. Richman LK, Chiller JM, Brown WR, et al: Enterically induced immunologic tolerance: I. Induction of suppressor T lymphocytes by intragastric administration of soluble proteins . J Immunol 1978;121:2429-2434. 17. Mestecky J, McGhee JR, Arnold RR, et al: Selective induction of an immune response in human external secretions by ingestion of bacterial antigen . J Clin Invest 1978;61:731-737.Crossref 18. Challacombe SJ, Lehner T: Salivary antibody response in rhesus monkeys immunized with Streptococcus mutans by the oral submucosal or subcutaneous routes . Arch Oral Biol 1980; 24:917-925.Crossref 19. Takasaka T, Kawamoto K: Mucociliary dysfunction in experimental otitis media with effusion . Am J Otolaryngol 1985;3:232-236.Crossref 20. Maxim PE, Veltri RW, Sprinkle PM: Chronic serous otitis media: An immune complex disease . Otolaryngology 1977;84:234-238. 21. Palva T, Lehtinen T, Rinne J: Immune complexes in middle ear fluid in chronic secretory otitis media . Ann Otol Rhinol Laryngol 1983; 92:42-44. 22. Owen RL, Jones AL: Epithelial cell specialization within human Peyer's patches: An ultrastructural study of intestinal lymphoid follicles . Gastroenterology 1974;66:189-203. 23. Mogi G, Watanabe N: Induction of antigenspecific IgA-forming cells in the middle ear mucosa , in Lim DJ, Bluestone CD, Klein JO, et al (eds): Recent Advances in Otitis Media . Philadelphia, BC Decker Inc, in press. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

Suppression of Immune-Mediated Otitis Media by T-Suppressor Cells

Loading next page...
 
/lp/american-medical-association/suppression-of-immune-mediated-otitis-media-by-t-suppressor-cells-jYb51IEN4i
Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.1988.01860200062019
Publisher site
See Article on Publisher Site

Abstract

Abstract • Effects of mucosa-derived T-suppressor cells on induction of IgG-mediated otitis media with effusion (OME) were investigated in mice, since antigenantibody reactions in the tympanic cavity are pathogenic mechanisms of OME. Splenic T-suppressor cells from strain C3H/HeN female mice, to which ovalbumin (OVA) had been orally administered, were transferred intravenously to syngeneic mice. The mice receiving the T-suppressor cells were immunized with OVA intraperitoneally and then injected with OVA into the tympanic cavity. Nine of ten control mice, to which splenic T cells from saline-fed mice were administered, developed OME, while OME was seen in only one of ten mice receiving splenic T cells from OVA-fed mice. The results show that IgG-mediated OME can be suppressed to a certain extent by the induction of antigen-specific, mucosa-derived, T-suppressor cells. (Arch Otolaryngol Head Neck Surg 1988;114:878-882) References 1. Ryan AF, Catanzaro A, Wasserman SI, et al: Secondary immune response in the middle ear: Immunological, morphological, and physiological observations . Ann Otol Rhinol Laryngol 1986;95:242-249. 2. Mogi G: Experimental OME with emphasis on mucosal immunity , in Feldman JE, Huizing EH, Lim DJ, et al (eds): Immunobiology, Histopathology, Tumor Immunology in Otorhinolaryngology . Amsterdam, Kugler Publications, 1987, pp 253-263. 3. Mravec J, Lewis DM, Lim DJ: Experimental otitis media with effusion: An immune complex-mediated response . Otolaryngology 1978;86:258-268. 4. Mogi G, Honjo S, Yoshida T, et al: Secretory immunoglobulin A (SIgA) in middle ear effusions: A further report . Ann Otol Rhinol Laryngol 1974;83:92-101. 5. Bernstein JM, Tomasi TB Jr, Ogra PL: The immunochemistry of middle ear effusions . Arch Otolaryngol Head Neck Surg 1974;99:320-326.Crossref 6. Richman LK, Graeff AS, Yarchean R, et al: Simultaneous induction of antigen-specific IgA helper T cells and IgG suppressor T cells in murine Peyer's patches after protein feeding . J Immunol 1981;126:2079-2083. 7. Challacombe SJ, Tomasi TB Jr: Systemic tolerance and secretory immunity after oral immunization . J Exp Med 1980;152:1459-1472.Crossref 8. Tomasi TB: Oral tolerance . Transplantation 1980;29:353-356.Crossref 9. Craig SW, Cebra JJ: Peyer's patches: An enriched source of precursors for IgA-producing immunocytes in the rabbit . J Exp Med 1974; 134:188-200.Crossref 10. Julius MH, Simpson E, Herzenberg LA: A rapid method for the isolation of functional thymus-derived murine lymphocytes . Eur J Immunol 1973;3:645-649.Crossref 11. Cunningham AJ, Szenberg A: Further improvements in the plaque technique for detecting single antibody-forming cells . Immunology 1968;14:599-600. 12. Suzuki M, Kawauchi M, Ueyama S, et al: Immune-mediated otitis media with effusion , in Lim DJ, Bluestone CD, Klein JO, et al (eds): Recent Advances in Otitis Media . Philadelphia, BC Decker Inc, in press. 13. Wells HG: Studies on the chemistry of anaphylaxis: III. Experiments with isolated proteins, especially those of the hen's egg . J Infect Dis 1911;9:147-171.Crossref 14. Chase MW: Inhibition of experimental drug allergy by prior feeding of the sensitizing agent . Proc Soc Exp Biol Med 1946;61:257-261.Crossref 15. Mattingly JA, Waksman BH: Immunologic suppression after oral administration of antigen: I. Specific suppressor cells formed in rat Peyer's patches after oral administration of sheep erythrocytes and their systemic migration . J Immunol 1978;121:1878-1883. 16. Richman LK, Chiller JM, Brown WR, et al: Enterically induced immunologic tolerance: I. Induction of suppressor T lymphocytes by intragastric administration of soluble proteins . J Immunol 1978;121:2429-2434. 17. Mestecky J, McGhee JR, Arnold RR, et al: Selective induction of an immune response in human external secretions by ingestion of bacterial antigen . J Clin Invest 1978;61:731-737.Crossref 18. Challacombe SJ, Lehner T: Salivary antibody response in rhesus monkeys immunized with Streptococcus mutans by the oral submucosal or subcutaneous routes . Arch Oral Biol 1980; 24:917-925.Crossref 19. Takasaka T, Kawamoto K: Mucociliary dysfunction in experimental otitis media with effusion . Am J Otolaryngol 1985;3:232-236.Crossref 20. Maxim PE, Veltri RW, Sprinkle PM: Chronic serous otitis media: An immune complex disease . Otolaryngology 1977;84:234-238. 21. Palva T, Lehtinen T, Rinne J: Immune complexes in middle ear fluid in chronic secretory otitis media . Ann Otol Rhinol Laryngol 1983; 92:42-44. 22. Owen RL, Jones AL: Epithelial cell specialization within human Peyer's patches: An ultrastructural study of intestinal lymphoid follicles . Gastroenterology 1974;66:189-203. 23. Mogi G, Watanabe N: Induction of antigenspecific IgA-forming cells in the middle ear mucosa , in Lim DJ, Bluestone CD, Klein JO, et al (eds): Recent Advances in Otitis Media . Philadelphia, BC Decker Inc, in press.

Journal

Archives of Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Aug 1, 1988

References