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Supplemental Testosterone and Estrone in Alloxan Diabetes of the Rat

Supplemental Testosterone and Estrone in Alloxan Diabetes of the Rat Abstract Conflicting clinical reports * have recently been published concerning the role of androgens and estrogens in diabetic retinopathy. Unfortunately, neither bioassays nor chemical analyses for tissue levels of these hormones are sufficiently accurate to support the endocrine hypotheses involved. Because of the divergent clinical conclusions and the current impassé in obtaining quantitative hormonal assays, a controlled laboratory study has been undertaken in an experimental diabetic animal. Albino rats rendered diabetic by alloxan were used, it being recognized that retinal vascular changes in the rat, as in most experimental diabetic animals, have been produced only with difficulty,† and only in the presence of some additional disturbance or tissue insult. Supplemental estrone was given to one group of diabetic rats in accordance with the hypothesis that this might precipitate additional tissue insult leading to retinopathy. Similarly, testosterone was given to another group on the basis that it might protect against the development of References 1. References 1 to 3. 2. References 4 to 6. 3. References 7 to 9. 4. Estrone was supplied as Estrone Lilly through the courtesy of Dr. W. R. Kirtley, of the Medical Department, Eli Lilly & Company, Indianapolis 6. 5. Testosterone was supplied as Depo-Testosterone Cyclopentylpropionate in oil (25 mg/cc.) through the courtesy of Dr. H. F. Hailman, of The Upjohn Company, Kalamazoo, Mich. 6. Practically identical with eosin Y. 7. Saskin, E.; Waldman, S., and Pelner, L.: Diabetic Retinopathy , Am. J. Ophth. 34:613, 1951. 8. Bedrossian, R. H.; Pocock, D. S.; Harvey, W. F., and Sindoni, A. S.: Diabetic Retinopathy Treated with Testosterone , A. M. A. Arch. Ophth. 50:277, 1953.Crossref 9. Pelner, L., and Waldman, S.: Diabetic Retinopathy , A. M. A. Arch. Ophth. 51:282, 1954.Crossref 10. Lewis, L. A.; Moses, J., and Schneider, R. W.: Alterations in Alloxan Diabetic Rabbits, Especially in Relation to Ocular Damage , Am. J. M. Sc. 213:214, 1947.Crossref 11. Schneider, R. W.; Lewis, L. A.; Moses, J., and McCullagh, E. P.: Retinal Hemorrhages and Lens Changes in Alloxan Diabetes in Rabbits , Proc. Central Soc. Clin. Res. 17:17, 1944. 12. Becker, B.: Diabetic Retinopathy , Ann. Int. Med. 37:273, 1952.Crossref 13. Hotchkiss, R. D.: A Microchemical Reaction Resulting in the Staining of Polysaccharide Structures in Fixed Tissue Preparations , Arch. Biochem. 16:131, 1948. 14. McManus, J. F. A.: Histochemical Demonstration of Mucin After Periodic Acid , Nature 158:202, 1946.Crossref 15. Friedenwald, J. S.: A New Approach to Some Problems of Retinal Vascular Disease , Am. J. Ophth. 32:487, 1949. 16. Keeney, A. H., and Barlow, F. D.: Histologic Techniques in the Demonstration of Retinal Vascular Patterns in the Albino Rat, in preparation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Ophthalmology American Medical Association

Supplemental Testosterone and Estrone in Alloxan Diabetes of the Rat

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Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-6339
DOI
10.1001/archopht.1955.00930010409014
Publisher site
See Article on Publisher Site

Abstract

Abstract Conflicting clinical reports * have recently been published concerning the role of androgens and estrogens in diabetic retinopathy. Unfortunately, neither bioassays nor chemical analyses for tissue levels of these hormones are sufficiently accurate to support the endocrine hypotheses involved. Because of the divergent clinical conclusions and the current impassé in obtaining quantitative hormonal assays, a controlled laboratory study has been undertaken in an experimental diabetic animal. Albino rats rendered diabetic by alloxan were used, it being recognized that retinal vascular changes in the rat, as in most experimental diabetic animals, have been produced only with difficulty,† and only in the presence of some additional disturbance or tissue insult. Supplemental estrone was given to one group of diabetic rats in accordance with the hypothesis that this might precipitate additional tissue insult leading to retinopathy. Similarly, testosterone was given to another group on the basis that it might protect against the development of References 1. References 1 to 3. 2. References 4 to 6. 3. References 7 to 9. 4. Estrone was supplied as Estrone Lilly through the courtesy of Dr. W. R. Kirtley, of the Medical Department, Eli Lilly & Company, Indianapolis 6. 5. Testosterone was supplied as Depo-Testosterone Cyclopentylpropionate in oil (25 mg/cc.) through the courtesy of Dr. H. F. Hailman, of The Upjohn Company, Kalamazoo, Mich. 6. Practically identical with eosin Y. 7. Saskin, E.; Waldman, S., and Pelner, L.: Diabetic Retinopathy , Am. J. Ophth. 34:613, 1951. 8. Bedrossian, R. H.; Pocock, D. S.; Harvey, W. F., and Sindoni, A. S.: Diabetic Retinopathy Treated with Testosterone , A. M. A. Arch. Ophth. 50:277, 1953.Crossref 9. Pelner, L., and Waldman, S.: Diabetic Retinopathy , A. M. A. Arch. Ophth. 51:282, 1954.Crossref 10. Lewis, L. A.; Moses, J., and Schneider, R. W.: Alterations in Alloxan Diabetic Rabbits, Especially in Relation to Ocular Damage , Am. J. M. Sc. 213:214, 1947.Crossref 11. Schneider, R. W.; Lewis, L. A.; Moses, J., and McCullagh, E. P.: Retinal Hemorrhages and Lens Changes in Alloxan Diabetes in Rabbits , Proc. Central Soc. Clin. Res. 17:17, 1944. 12. Becker, B.: Diabetic Retinopathy , Ann. Int. Med. 37:273, 1952.Crossref 13. Hotchkiss, R. D.: A Microchemical Reaction Resulting in the Staining of Polysaccharide Structures in Fixed Tissue Preparations , Arch. Biochem. 16:131, 1948. 14. McManus, J. F. A.: Histochemical Demonstration of Mucin After Periodic Acid , Nature 158:202, 1946.Crossref 15. Friedenwald, J. S.: A New Approach to Some Problems of Retinal Vascular Disease , Am. J. Ophth. 32:487, 1949. 16. Keeney, A. H., and Barlow, F. D.: Histologic Techniques in the Demonstration of Retinal Vascular Patterns in the Albino Rat, in preparation.

Journal

A.M.A. Archives of OphthalmologyAmerican Medical Association

Published: Mar 1, 1955

References

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