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Supplemental Dietary Tyrosine in Sepsis and Acute Hemorrhagic Shock

Supplemental Dietary Tyrosine in Sepsis and Acute Hemorrhagic Shock Abstract • Previous studies showed that dopamine and norepinephrine levels in rat brain are reduced following stress and that rats fed supplemental tyrosine do not exhibit these reductions. We hypothesized that dietary supplementation with tyrosine would enhance resistance to acute hemorrhagic shock and sepsis by increasing substrate (tyrosine) availability for catecholamine synthesis. Rats were fed either a standard rat chow (6.8 g of tyrosine per kilogram of chow), which supports normal growth, fertility, and longevity, or the same chow supplemented with 10 g of tyrosine per kilogram of chow. Seven days later, the rats underwent cecal ligation and perforation while under intraperitoneal pentobarbital anesthesia. There was a significant increase in survival in the tyrosinesupplemented group. Similarly, in another experiment, tyrosine-supplemented rats were able to tolerate acute fulminant hemorrhagic shock better than were nonsupplemented control animals. (Arch Surg 1987;122:78-81) References 1. Brady K, Brown JW, Thurmond JB: Behavioral and neurochemical effects of dietary tyrosine in young and aged mice following cold swim—stress . Pharmacol Biochem Behav 1979;12:667-674.Crossref 2. Lehnert H, Reinstein DK, Strowbridge BW, et al: Neurochemical and behavioral consequences of acute uncontrollable stress: Effects of dietary tyrosine . Brain Res 1984;303:215-223.Crossref 3. Reinstein DK, Lehnert H, Scott NA, et al: Tyrosine prevents behavioral and neurochemical correlates of an acute stress in rats . Life Sci 1984;34:2225-2231.Crossref 4. Gibson CJ, Wurtman RJ: Physiological control of brain norepinephrine synthesis by brain tyrosine concentration . Life Sci 1978;22:1399-1406.Crossref 5. Wurtman RJ, Larin F, Mostafapour S, et al: Brain catechol synthesis: Control by brain tyrosine concentration . Science 1974;204:183-184.Crossref 6. Page IH: Some neurohumoral and endocrine aspects of shock . Fed Proc 1961;20:75-98. 7. Nickerson M: Neuroendocrine and metabolic aspects of shock . Fed Proc 1961;20:201-205. 8. Freeman NE, Shaffer SA, Schecter AE, et al: The effect of total sympathectomy on the occurrence of shock from hemorrhage . J Clin Invest 1938;17:359-368.Crossref 9. Chaudry IH, Wichterman KA, Baue AE: Effect of sepsis on tissue adenine nucleotide levels . Surgery 1979;85:205-211. 10. Wang L: Plasma volume, cell volume, total blood volume and F cells factor in the normal and splenectomized Sherman rat . Am J Physiol 1959;196:188-192. 11. Alousi A, Weiner N: The regulation of norepinephrine synthesis in sympathetic nerves: Effect of nerve stimulation, cocaine, and catecholamine releasing agents . Proc Natl Acad Sci USA 1966;56:1491-1496.Crossref 12. Joh TH, Geghman D, Reis D: Immunochemical demonstration of increased accumulation of tyrosine hydroxylase protein in sympathetic ganglia and adrenal medulla elicited by reserpine . Proc Natl Acad Sci USA 1973;70:2767-2770.Crossref 13. Conlay LA, Maher TJ, Wurtman RJ: Tyrosine accelerates catecholamine synthesis in hemorrhaged hypotensive rats . Brain Res 1985;333: 81-84.Crossref 14. Conlay LA, Maher TJ, Wurtman RJ: Tyrosine's pressor effect in hypotensive rats is not mediated by tyramine . Life Sci 1984;35:1207-1212.Crossref 15. Conlay LA, Maher TJ, Wurtman RJ: Tyrosine increases blood pressure in hypotensive rats . Science 1981;212:559-560.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Supplemental Dietary Tyrosine in Sepsis and Acute Hemorrhagic Shock

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1987.01400130084013
Publisher site
See Article on Publisher Site

Abstract

Abstract • Previous studies showed that dopamine and norepinephrine levels in rat brain are reduced following stress and that rats fed supplemental tyrosine do not exhibit these reductions. We hypothesized that dietary supplementation with tyrosine would enhance resistance to acute hemorrhagic shock and sepsis by increasing substrate (tyrosine) availability for catecholamine synthesis. Rats were fed either a standard rat chow (6.8 g of tyrosine per kilogram of chow), which supports normal growth, fertility, and longevity, or the same chow supplemented with 10 g of tyrosine per kilogram of chow. Seven days later, the rats underwent cecal ligation and perforation while under intraperitoneal pentobarbital anesthesia. There was a significant increase in survival in the tyrosinesupplemented group. Similarly, in another experiment, tyrosine-supplemented rats were able to tolerate acute fulminant hemorrhagic shock better than were nonsupplemented control animals. (Arch Surg 1987;122:78-81) References 1. Brady K, Brown JW, Thurmond JB: Behavioral and neurochemical effects of dietary tyrosine in young and aged mice following cold swim—stress . Pharmacol Biochem Behav 1979;12:667-674.Crossref 2. Lehnert H, Reinstein DK, Strowbridge BW, et al: Neurochemical and behavioral consequences of acute uncontrollable stress: Effects of dietary tyrosine . Brain Res 1984;303:215-223.Crossref 3. Reinstein DK, Lehnert H, Scott NA, et al: Tyrosine prevents behavioral and neurochemical correlates of an acute stress in rats . Life Sci 1984;34:2225-2231.Crossref 4. Gibson CJ, Wurtman RJ: Physiological control of brain norepinephrine synthesis by brain tyrosine concentration . Life Sci 1978;22:1399-1406.Crossref 5. Wurtman RJ, Larin F, Mostafapour S, et al: Brain catechol synthesis: Control by brain tyrosine concentration . Science 1974;204:183-184.Crossref 6. Page IH: Some neurohumoral and endocrine aspects of shock . Fed Proc 1961;20:75-98. 7. Nickerson M: Neuroendocrine and metabolic aspects of shock . Fed Proc 1961;20:201-205. 8. Freeman NE, Shaffer SA, Schecter AE, et al: The effect of total sympathectomy on the occurrence of shock from hemorrhage . J Clin Invest 1938;17:359-368.Crossref 9. Chaudry IH, Wichterman KA, Baue AE: Effect of sepsis on tissue adenine nucleotide levels . Surgery 1979;85:205-211. 10. Wang L: Plasma volume, cell volume, total blood volume and F cells factor in the normal and splenectomized Sherman rat . Am J Physiol 1959;196:188-192. 11. Alousi A, Weiner N: The regulation of norepinephrine synthesis in sympathetic nerves: Effect of nerve stimulation, cocaine, and catecholamine releasing agents . Proc Natl Acad Sci USA 1966;56:1491-1496.Crossref 12. Joh TH, Geghman D, Reis D: Immunochemical demonstration of increased accumulation of tyrosine hydroxylase protein in sympathetic ganglia and adrenal medulla elicited by reserpine . Proc Natl Acad Sci USA 1973;70:2767-2770.Crossref 13. Conlay LA, Maher TJ, Wurtman RJ: Tyrosine accelerates catecholamine synthesis in hemorrhaged hypotensive rats . Brain Res 1985;333: 81-84.Crossref 14. Conlay LA, Maher TJ, Wurtman RJ: Tyrosine's pressor effect in hypotensive rats is not mediated by tyramine . Life Sci 1984;35:1207-1212.Crossref 15. Conlay LA, Maher TJ, Wurtman RJ: Tyrosine increases blood pressure in hypotensive rats . Science 1981;212:559-560.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Jan 1, 1987

References