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Superoxide Radical Scavenging Agents in Treatment of Alkali Burns: An Experimental Study

Superoxide Radical Scavenging Agents in Treatment of Alkali Burns: An Experimental Study Abstract • To test the hypothesis that superoxide radicals are involved in tissue destruction after alkali burns, superoxide dismutase, ascorbic acid, and glutathione were used as superoxide radical scavenging agents. Daily subconjunctival injections were given in rabbit eyes after alkali burns. Both superoxide dismutase and ascorbic acid were effective in preventing corneal perforations. Glutathione did not show any beneficial effect. These experiments suggest that superoxide radical scavenging agents may be useful in the treatment of ocular alkali burns. References 1. Hughes WF: Alkali burns of the eye: II. Clinical and pathological course . Arch Ophthalmol 1946;36:189-214.Crossref 2. Slansky MM, Freeman ML, Itol M: Collagenolytic activity in bovine corneal epithelium . Arch Ophthalmol 1968;80:496-498.Crossref 3. Brown SI, Weller CA, Wasserman HE: Collagenolytic activity of alkali burned corneas . Arch Ophthalmol 1969;81:370-373.Crossref 4. Brown SI, Weller CA: Cell origin of collagenase in normal and wounded corneas . Arch Ophthalmol 1970;83:74-77.Crossref 5. Gnadinger MS, Itoi M, Slansky MH, et al: The role of collagenase in the alkali burned cornea . Am J Ophthalmol 1969;68:478-483. 6. Brown SI, Akiya S, Weller CA: Prevention of ulcers of the alkali burned cornea: Preliminary studies with collagenase inhibitors . Arch Ophthalmol 1969;82:95-97.Crossref 7. Brown SI, Weller CA: Collagenase inhibitors in prevention of ulcers of alkali burned corneas . Arch Ophthalmol 1970;83:352-353.Crossref 8. Dohlman CH, Pfister RR: Management of chemical burns of the eye , in Symposium on the Cornea . St Louis, CV Mosby Co, 1972, pp 105-120. 9. Brown SI, Tragakis MP, Pearce DB: Treatment of the alkali burned cornea . Am J Ophthalmol 1972;74:316-320. 10. Newsome DA, Gross J: Prevention by medroxyprogesterone of perforation in the alkali burned rabbit cornea: Inhibition of collagenolytic activity . Invest Ophthalmol Vis Sci 1977;16:21-31. 11. Levinson RA, Paterson CA, Pfister RR: Ascorbic acid prevents corneal ulceration and perforation following experimental alkali burns . Invest Ophthalmol Vis Sci 1976;15:986-993. 12. Pfister RR, Paterson CA: Additional clinical and morphological observations of the favorable effect of ascorbate in experimental ocular alkali burns . Invest Ophthalmol Vis Sci 1972;16:478-487. 13. Pfister RR, Paterson CA, Hayes CA: Topical ascorbate decreases the incidence of corneal ulceration after experimental alkali burns . Invest Ophthalmol Vis Sci 1978;17:1019-1024. 14. Varma SD, Ets TK, Richards RD: Protection against superoxide radicals in rat lens . Ophthalmic Res 1972;9:421-431.Crossref 15. Fridovich I: Biology of oxygen radicals . Science 1978;201:875-880.Crossref 16. Kirkpatrick D, McGinnes J: A superoxide producing system in the conjunctival mucus thread . Invest Ophthalmol Vis Sci 1972;16:762-765. 17. Varma SD, Kumar S, Richards RD: Lightinduced damage to ocular lens cation pump: Prevention by vitamin C : Proc Natl Acad Sci USA 1979;76:3504-3506.Crossref 18. Varma SD: Photodamage to the lens by superoxide: Protection by aqueous humor ascorbate , in Srivastava VK (ed): Red Blood Cell and Lens Symposium . New York, Elsevier North Holland Inc, 1980. 19. Varma SD, Srivastava VK, Richards RD: Photoperoxidation in rat lens: Preventive mechanisms . Invest Ophthalmol Vis Sci (suppl 19) , 1980, p 13. 20. Long S (ed): Biochemists Handbook . Princeton, NJ, Van Nostrand Publishers 1961, p 93. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Superoxide Radical Scavenging Agents in Treatment of Alkali Burns: An Experimental Study

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Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1981.03930010886020
Publisher site
See Article on Publisher Site

Abstract

Abstract • To test the hypothesis that superoxide radicals are involved in tissue destruction after alkali burns, superoxide dismutase, ascorbic acid, and glutathione were used as superoxide radical scavenging agents. Daily subconjunctival injections were given in rabbit eyes after alkali burns. Both superoxide dismutase and ascorbic acid were effective in preventing corneal perforations. Glutathione did not show any beneficial effect. These experiments suggest that superoxide radical scavenging agents may be useful in the treatment of ocular alkali burns. References 1. Hughes WF: Alkali burns of the eye: II. Clinical and pathological course . Arch Ophthalmol 1946;36:189-214.Crossref 2. Slansky MM, Freeman ML, Itol M: Collagenolytic activity in bovine corneal epithelium . Arch Ophthalmol 1968;80:496-498.Crossref 3. Brown SI, Weller CA, Wasserman HE: Collagenolytic activity of alkali burned corneas . Arch Ophthalmol 1969;81:370-373.Crossref 4. Brown SI, Weller CA: Cell origin of collagenase in normal and wounded corneas . Arch Ophthalmol 1970;83:74-77.Crossref 5. Gnadinger MS, Itoi M, Slansky MH, et al: The role of collagenase in the alkali burned cornea . Am J Ophthalmol 1969;68:478-483. 6. Brown SI, Akiya S, Weller CA: Prevention of ulcers of the alkali burned cornea: Preliminary studies with collagenase inhibitors . Arch Ophthalmol 1969;82:95-97.Crossref 7. Brown SI, Weller CA: Collagenase inhibitors in prevention of ulcers of alkali burned corneas . Arch Ophthalmol 1970;83:352-353.Crossref 8. Dohlman CH, Pfister RR: Management of chemical burns of the eye , in Symposium on the Cornea . St Louis, CV Mosby Co, 1972, pp 105-120. 9. Brown SI, Tragakis MP, Pearce DB: Treatment of the alkali burned cornea . Am J Ophthalmol 1972;74:316-320. 10. Newsome DA, Gross J: Prevention by medroxyprogesterone of perforation in the alkali burned rabbit cornea: Inhibition of collagenolytic activity . Invest Ophthalmol Vis Sci 1977;16:21-31. 11. Levinson RA, Paterson CA, Pfister RR: Ascorbic acid prevents corneal ulceration and perforation following experimental alkali burns . Invest Ophthalmol Vis Sci 1976;15:986-993. 12. Pfister RR, Paterson CA: Additional clinical and morphological observations of the favorable effect of ascorbate in experimental ocular alkali burns . Invest Ophthalmol Vis Sci 1972;16:478-487. 13. Pfister RR, Paterson CA, Hayes CA: Topical ascorbate decreases the incidence of corneal ulceration after experimental alkali burns . Invest Ophthalmol Vis Sci 1978;17:1019-1024. 14. Varma SD, Ets TK, Richards RD: Protection against superoxide radicals in rat lens . Ophthalmic Res 1972;9:421-431.Crossref 15. Fridovich I: Biology of oxygen radicals . Science 1978;201:875-880.Crossref 16. Kirkpatrick D, McGinnes J: A superoxide producing system in the conjunctival mucus thread . Invest Ophthalmol Vis Sci 1972;16:762-765. 17. Varma SD, Kumar S, Richards RD: Lightinduced damage to ocular lens cation pump: Prevention by vitamin C : Proc Natl Acad Sci USA 1979;76:3504-3506.Crossref 18. Varma SD: Photodamage to the lens by superoxide: Protection by aqueous humor ascorbate , in Srivastava VK (ed): Red Blood Cell and Lens Symposium . New York, Elsevier North Holland Inc, 1980. 19. Varma SD, Srivastava VK, Richards RD: Photoperoxidation in rat lens: Preventive mechanisms . Invest Ophthalmol Vis Sci (suppl 19) , 1980, p 13. 20. Long S (ed): Biochemists Handbook . Princeton, NJ, Van Nostrand Publishers 1961, p 93.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: May 1, 1981

References

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