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Sulindac-Induced Aseptic Meningitis

Sulindac-Induced Aseptic Meningitis Abstract • A 22-year-old woman with systemic lupus erythematosus experienced generalized pruritus, shortness of breath, pleuritic chest pain, visual blurring, severe photophobia, a stiff neck, an occipital headache, and a temperature of 39.4 °C within one hour after taking sulindac (Clinoril). Findings from a CSF examination disclosed a notable elevation of protein and a polymorphonuclear pleocytosis. All symptoms disappeared within 24 hours. Inhibition of prostaglandin synthesis did not seem to be the mechanism of this adverse reaction, since the patient tolerated aspirin. (Arch Intern Med 1982;142:165-166) References 1. Ruppert GB, Barth WF: Tolmetin-induced aseptic meningitis. JAMA 1981;245:67-68.Crossref 2. Bernstein RF: Ibuprofen-related meningitis in mixed connective tissue disease. Ann Intern Med 1980;92:206-207.Crossref 3. Widener HL, Littman BH: Ibuprofen-induced meningitis in systemic lupus erythematosus. JAMA 1978;239:1062-1064.Crossref 4. Johnson RT, Richardson EP: The neurological manifestations of systemic lupus erythematosus. Medicine 1968;47:337-369.Crossref 5. Canoso J, Cohen A: Aseptic meningitis in systemic lupus erythematosus. Arthritis Rheum 1975;18:369-374.Crossref 6. Finelli PF, Yockey CC, Hebert AJ: Recurrent aseptic meningitis in an elderly man. JAMA 1976;235:1142-1143.Crossref 7. Sergent JS, Lockshin MD, Klempner MS, et al: Central nervous system disease in systemic lupus erythematosus. Am J Med 1975;58:644-654.Crossref 8. Fauci AS, Steinberg AD, Haynes BF, et al: Immunoregulatory aberrations in systemic lupus erythematosus. J Immunol 1978;121:1473-1479. 9. Shoenfeld Y, Livni E, Shaklai M, et al: Sensitization to ibuprofen in systemic lupus erythematosus. JAMA 1980;244:547-548.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Sulindac-Induced Aseptic Meningitis

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1982.00340140167031
Publisher site
See Article on Publisher Site

Abstract

Abstract • A 22-year-old woman with systemic lupus erythematosus experienced generalized pruritus, shortness of breath, pleuritic chest pain, visual blurring, severe photophobia, a stiff neck, an occipital headache, and a temperature of 39.4 °C within one hour after taking sulindac (Clinoril). Findings from a CSF examination disclosed a notable elevation of protein and a polymorphonuclear pleocytosis. All symptoms disappeared within 24 hours. Inhibition of prostaglandin synthesis did not seem to be the mechanism of this adverse reaction, since the patient tolerated aspirin. (Arch Intern Med 1982;142:165-166) References 1. Ruppert GB, Barth WF: Tolmetin-induced aseptic meningitis. JAMA 1981;245:67-68.Crossref 2. Bernstein RF: Ibuprofen-related meningitis in mixed connective tissue disease. Ann Intern Med 1980;92:206-207.Crossref 3. Widener HL, Littman BH: Ibuprofen-induced meningitis in systemic lupus erythematosus. JAMA 1978;239:1062-1064.Crossref 4. Johnson RT, Richardson EP: The neurological manifestations of systemic lupus erythematosus. Medicine 1968;47:337-369.Crossref 5. Canoso J, Cohen A: Aseptic meningitis in systemic lupus erythematosus. Arthritis Rheum 1975;18:369-374.Crossref 6. Finelli PF, Yockey CC, Hebert AJ: Recurrent aseptic meningitis in an elderly man. JAMA 1976;235:1142-1143.Crossref 7. Sergent JS, Lockshin MD, Klempner MS, et al: Central nervous system disease in systemic lupus erythematosus. Am J Med 1975;58:644-654.Crossref 8. Fauci AS, Steinberg AD, Haynes BF, et al: Immunoregulatory aberrations in systemic lupus erythematosus. J Immunol 1978;121:1473-1479. 9. Shoenfeld Y, Livni E, Shaklai M, et al: Sensitization to ibuprofen in systemic lupus erythematosus. JAMA 1980;244:547-548.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jan 1, 1982

References