THE CUTTING EDGE: CHALLENGES IN MEDICAL AND SURGICAL THERAPIES SECTION EDITOR: EDWARD W. COWEN, MD, MHSc; ASSISTANT SECTION EDITORS: MURAD ALAM, MD; RUTH ANN VLEUGELS, MD Successful Treatment of Subacute Lupus Erythematosus With Ustekinumab Aieska De Souza, MD; Trisha Ali-Shaw, BA; Bruce E. Strober, MD, PhD; Andrew G. Franks Jr, MD; Department of Dermatology (Drs De Souza, Strober, and Franks and Ms Ali-Shaw) and Division of Rheumatology, Department of Medicine (Dr Franks), New York University, New York REPORT OF A CASE THERAPEUTIC CHALLENGE A 58-year-old woman presented with a history of sub- Patients with cutaneous lupus erythematosus experi- 1,2 acute cutaneous lupus erythematosus (SCLE) for the past ence significant morbidity. Current therapeutic 6 years, associated with photosensitivity, arthralgia, and options benefit the majority of patients; however, up fatigue. There was no evidence of systemic lupus ery- to 15% of cases are refractory to these conventional 3,4 thematosus (SLE) or any history of exposure to drugs therapies. General treatment recommendations known to induce SCLE. Previous treatments included hy- involve avoidance of direct sunlight, smoking cessa- droxychloroquine sulfate, dapsone, prednisone, azathio- tion, and the discontinuation of any drugs suspected 1-4 prine, mycophenolate mofetil, topical corticosteroids, and of inducing or exacerbating SCLE.
JAMA Dermatology – American Medical Association
Published: Aug 1, 2011
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